Development Level

Tbio 16 | 11,445
Tchem 16 | 1,598
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
preweaning lethality, complete... 4 | 979
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
cataract 1 | 92
decreased body weight 1 | 161
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased leukocyte cell numbe... 1 | 47
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15

Disease

Carcinoma 34 | 11,493
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
medulloblastoma, large-cell 24 | 6,241
ovarian cancer 22 | 8,520
ependymoma 21 | 4,679
primitive neuroectodermal tumor 20 | 3,035
psoriasis 20 | 6,694
group 3 medulloblastoma 19 | 4,104
oligodendroglioma 19 | 2,850
adult high grade glioma 18 | 3,801
Kidney cancer 17 | 2,613
Schizophrenia 17 | 1,160
Cancer 16 | 2,499
Astrocytoma, Pilocytic 15 | 3,081
Bipolar Disorder 15 | 666
astrocytic glioma 15 | 2,597
osteosarcoma 15 | 7,950
Depressive disorder 14 | 409
Pick disease 14 | 1,894
Substance Withdrawal Syndrome 14 | 55
Intellectual disability 13 | 1,016
lung cancer 13 | 4,740
Epilepsy 12 | 792
Cocaine-Related Disorders 11 | 92
Major Depressive Disorder 11 | 301
Mental Depression 11 | 333
Parkinson's disease 11 | 392
Short stature 11 | 531
lung adenocarcinoma 11 | 2,716
pancreatic cancer 11 | 2,398
Unipolar Depression 10 | 250
lung carcinoma 10 | 2,843
subependymal giant cell astrocytoma 10 | 2,287
Alcoholic Intoxication, Chronic 9 | 289
Alzheimer's disease 9 | 658
pituitary cancer 9 | 1,972
Breast cancer 8 | 3,578
Dull intelligence 8 | 645
Liver cancer 8 | 604
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Toxic encephalopathy 8 | 141
Attention deficit hyperactivity disorder 7 | 278
Blepharoptosis 7 | 231
General anesthesia 7 | 53
Melanoma 7 | 711
Muscle hypotonia 7 | 571
Obesity 7 | 678
Vascular disease 7 | 319
invasive ductal carcinoma 7 | 2,951
Acquired scoliosis 6 | 281
Acromegaly 6 | 51
Adenoma 6 | 167
Alcohol dependence 6 | 107
Autistic Disorder 6 | 364
Carney complex 6 | 25
Cognitive delay 6 | 608
Curvature of spine 6 | 282
Global developmental delay 6 | 608
Hyperactive behavior 6 | 91
Hyperalgesia 6 | 83
Hyperkinesis 6 | 32
Kidney disease 6 | 430
Local anesthesia 6 | 40
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332
Seizures 6 | 596
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Brachydactyly 5 | 156
Byzanthine arch palate 5 | 194
Cushing's syndrome 5 | 48
Huntington's disease 5 | 76
Lennox-Gastaut syndrome 5 | 34
Lung Neoplasms 5 | 232
Mood Disorders 5 | 184
Neurodegenerative disease 5 | 414
Pituitary adenoma 5 | 38
Polycystic ovary syndrome 5 | 360
Primary pigmented nodular adrenocortical disease 5 | 13
Short neck 5 | 140
Simple partial seizure 5 | 26
Skin cancer 5 | 469
Strabismus 5 | 270
Substance abuse 5 | 59
pediatric high grade glioma 5 | 1,064
substance-related disorder 5 | 162
Brain Ischemia 4 | 110
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Heart disease 4 | 306
Long philtrum 4 | 137
Pediatric failure to thrive 4 | 365
Schizoaffective Disorder 4 | 55

Tissue

Endocrine System 40 | 18,159
Female tissues 39 | 17,400
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Skin and soft tissues 38 | 17,230
Digestive Tract 37 | 17,369
Liver and Pancreas 36 | 16,750
Respiratory system 35 | 16,393
Urinary Tract 35 | 16,678
Blood and immune system 34 | 16,909
Cardiovascular System 32 | 15,192

Target Family

Kinase 14 | 634
Non-IDG 9 | 12,091
Enzyme 8 | 4,145
Ion Channel 6 | 344
GPCR 5 | 408
Transcription Factor 1 | 1,400

WikiPathways Pathway

Common Pathways Underlying Dru... 43 | 43
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Actin, gamma-enteric smooth muscle ACTG2 Tbio Non-IDG -1.98240 92.4 212
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.61657 45.3 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509