Development Level

Tbio 108 | 11,445
Tchem 55 | 1,598
Tclin 35 | 613
Tdark 2 | 6,588

Collection

GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
embryonic lethality prior to t... 7 | 278
decreased total body fat amoun... 6 | 207
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
enlarged heart 5 | 210
decreased body length 4 | 101
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
decreased vertical activity 4 | 208
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral density 3 | 126
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating calcium ... 3 | 34
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
male infertility 3 | 123
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating alkaline... 2 | 46
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
female infertility 2 | 60
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating total pr... 2 | 28
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
microphthalmia 2 | 26
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal locomotor activation 1 | 16
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
cardiovascular system phenotyp... 1 | 36
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
edema 1 | 59
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased vertical activity 1 | 24
limb grasping 1 | 41
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
thin ventricular wall 1 | 24
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 141 | 11,493
ovarian cancer 104 | 8,520
psoriasis 102 | 6,694
medulloblastoma, large-cell 96 | 6,241
osteosarcoma 94 | 7,950
glioblastoma 89 | 5,792
Cancer 86 | 2,499
atypical teratoid / rhabdoid tumor 84 | 5,112
lung cancer 73 | 4,740
ependymoma 68 | 4,679
Schizophrenia 64 | 1,160
primitive neuroectodermal tumor 58 | 3,035
Breast cancer 55 | 3,578
adult high grade glioma 55 | 3,801
group 3 medulloblastoma 54 | 4,104
malignant mesothelioma 54 | 3,232
oligodendroglioma 51 | 2,850
diabetes mellitus 47 | 1,728
Bipolar Disorder 46 | 666
non-small cell lung cancer 46 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
Obesity 44 | 678
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
astrocytic glioma 40 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
Depressive disorder 39 | 409
Kidney cancer 39 | 2,613
invasive ductal carcinoma 39 | 2,951
lung carcinoma 39 | 2,843
Astrocytoma, Pilocytic 38 | 3,081
interstitial cystitis 37 | 2,312
lung adenocarcinoma 37 | 2,716
Mental Depression 35 | 333
pituitary cancer 35 | 1,972
ulcerative colitis 35 | 1,819
colon cancer 34 | 1,478
group 4 medulloblastoma 33 | 1,855
pancreatic cancer 32 | 2,398
subependymal giant cell astrocytoma 32 | 2,287
tuberculosis 30 | 2,010
Autistic Disorder 28 | 364
Epilepsy 28 | 792
adrenocortical carcinoma 28 | 1,428
breast carcinoma 28 | 1,638
Pick disease 27 | 1,894
Hypertension 26 | 396
Major Depressive Disorder 26 | 301
Mood Disorders 26 | 184
Seizures 25 | 596
ductal carcinoma in situ 24 | 1,745
Alzheimer's disease 23 | 658
Autosomal recessive predisposition 23 | 1,442
Intellectual disability 23 | 1,016
astrocytoma 23 | 1,146
Alcoholic Intoxication, Chronic 22 | 289
Parkinson's disease 22 | 392
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Multiple myeloma 21 | 1,332
Prostatic Neoplasms 21 | 495
Breast Neoplasms 19 | 445
Endometriosis 19 | 540
Mammary Neoplasms 19 | 425
Rheumatoid arthritis 19 | 1,191
Unipolar Depression 19 | 250
cystic fibrosis 19 | 1,696
Atherosclerosis 18 | 291
acute quadriplegic myopathy 18 | 1,158
nasopharyngeal carcinoma 18 | 1,058
Atopic dermatitis 17 | 952
Attention deficit hyperactivity disorder 17 | 278
Dull intelligence 17 | 645
Hyperglycemia 17 | 137
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Waldenstrons macroglobulinemia 17 | 765
acute myeloid leukemia 17 | 783
spina bifida 17 | 1,074
Asthma 16 | 385
Kidney disease 16 | 430
Substance Withdrawal Syndrome 16 | 55
aldosterone-producing adenoma 16 | 665
primary pancreatic ductal adenocarcinoma 16 | 1,109
Alcohol dependence 15 | 107
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Heart disease 15 | 306
Hypertensive disease 15 | 292
Liver disease 15 | 237
Melanoma 15 | 711
Mental and motor retardation 15 | 608
Vascular disease 15 | 319
Cocaine-Related Disorders 14 | 92
Diabetes Mellitus, Non-Insulin-Dependent 14 | 145
Muscle hypotonia 14 | 571
Polycystic ovary syndrome 14 | 360
Stomach Neoplasms 14 | 300
juvenile dermatomyositis 14 | 1,187
pediatric high grade glioma 14 | 1,064

Tissue

Endocrine System 198 | 18,159
Female tissues 191 | 17,400
Digestive Tract 189 | 17,369
Nervous System 189 | 16,725
Skin and soft tissues 186 | 17,230
Male tissues 183 | 17,142
Blood and immune system 181 | 16,909
Liver and Pancreas 180 | 16,750
Urinary Tract 178 | 16,678
Respiratory system 175 | 16,393
Cardiovascular System 167 | 15,192

Target Family

Non-IDG 64 | 12,091
Transcription Factor 37 | 1,400
Enzyme 34 | 4,145
GPCR 20 | 408
Kinase 17 | 634
Epigenetic 11 | 242
Nuclear Receptor 9 | 48
Ion Channel 4 | 344
TF/Epigenetic 2 | 38
Transporter 2 | 473

WikiPathways Pathway

Circadian rythm related genes 200 | 200
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075