Development Level

Tbio 41 | 11,445
Tchem 26 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased eosinophil cell numb... 2 | 24
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
hyperactivity 2 | 148
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Cancer 60 | 2,499
Carcinoma 55 | 11,493
ovarian cancer 49 | 8,520
glioblastoma 44 | 5,792
psoriasis 40 | 6,694
osteosarcoma 39 | 7,950
medulloblastoma, large-cell 37 | 6,241
atypical teratoid / rhabdoid tumor 35 | 5,112
ependymoma 34 | 4,679
lung cancer 30 | 4,740
group 3 medulloblastoma 29 | 4,104
Breast cancer 27 | 3,578
diabetes mellitus 24 | 1,728
malignant mesothelioma 24 | 3,232
Stomach Neoplasms 22 | 300
adult high grade glioma 22 | 3,801
primitive neuroectodermal tumor 22 | 3,035
oligodendroglioma 21 | 2,850
pancreatic cancer 21 | 2,398
Kidney cancer 20 | 2,613
Prostatic Neoplasms 20 | 495
Astrocytoma, Pilocytic 19 | 3,081
Colorectal Neoplasms 19 | 243
Schizophrenia 19 | 1,160
Colonic Neoplasms 18 | 142
Vascular disease 18 | 319
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Lung Neoplasms 17 | 232
tuberculosis 17 | 2,010
Adenoma 16 | 167
Breast Neoplasms 16 | 445
invasive ductal carcinoma 16 | 2,951
subependymal giant cell astrocytoma 16 | 2,287
Depressive disorder 15 | 409
Epilepsy 15 | 792
Familial adenomatous polyposis 15 | 32
Intellectual disability 15 | 1,016
Mammary Neoplasms 15 | 425
astrocytic glioma 15 | 2,597
breast carcinoma 15 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
lung adenocarcinoma 15 | 2,716
pituitary cancer 15 | 1,972
Carcinoma, Hepatocellular 14 | 228
Kidney disease 14 | 430
Liver carcinoma 14 | 240
Obesity 14 | 678
Seizures 14 | 596
adrenocortical carcinoma 14 | 1,428
lung carcinoma 14 | 2,843
Alzheimer's disease 13 | 658
Hypertensive disease 13 | 292
Multiple myeloma 13 | 1,332
Neoplasm Metastasis 13 | 168
Rheumatoid arthritis 13 | 1,191
group 4 medulloblastoma 13 | 1,855
Orbital separation excessive 12 | 244
Parkinson's disease 12 | 392
Squamous cell carcinoma 12 | 129
astrocytoma 12 | 1,146
non-small cell lung cancer 12 | 2,890
Adenocarcinoma 11 | 122
Brain Ischemia 11 | 110
Byzanthine arch palate 11 | 194
Cell Transformation, Neoplastic 11 | 97
Dull intelligence 11 | 645
Heart disease 11 | 306
Liver Cirrhosis, Experimental 11 | 769
Liver Neoplasms, Experimental 11 | 59
Low intelligence 11 | 645
Melanoma 11 | 711
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Renal Cell Carcinoma 11 | 214
Toxic encephalopathy 11 | 141
Waldenstrons macroglobulinemia 11 | 765
acute myeloid leukemia 11 | 783
ductal carcinoma in situ 11 | 1,745
hepatocellular carcinoma 11 | 547
nasopharyngeal carcinoma 11 | 1,058
ulcerative colitis 11 | 1,819
Acquired scoliosis 10 | 281
Amyotrophic lateral sclerosis 10 | 451
Bipolar Disorder 10 | 666
Curvature of spine 10 | 282
Disease Models, Animal 10 | 155
Endometrial cancer 10 | 311
Hypertension 10 | 396
Liver disease 10 | 237
Lung disease 10 | 142
Muscle hypotonia 10 | 571
Pick disease 10 | 1,894
acute quadriplegic myopathy 10 | 1,158
juvenile dermatomyositis 10 | 1,187
medulloblastoma 10 | 720
ovarian neoplasm 10 | 99
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pediatric high grade glioma 10 | 1,064

Tissue

Blood and immune system 72 | 16,909
Digestive Tract 72 | 17,369
Endocrine System 72 | 18,159
Nervous System 72 | 16,725
Female tissues 71 | 17,400
Male tissues 71 | 17,142
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678
Liver and Pancreas 70 | 16,750
Respiratory system 70 | 16,393
Cardiovascular System 69 | 15,192

Target Family

Non-IDG 31 | 12,091
Kinase 18 | 634
Enzyme 12 | 4,145
Transcription Factor 12 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

Chromosomal and microsatellite... 74 | 74
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Ral guanine nucleotide dissociation stimulator RALGDS Tbio Non-IDG -2.85677 683.6 102
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313