Development Level

Tchem 10 | 1,598
Tbio 3 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
embryonic growth retardation 1 | 106
hydrometra 1 | 53
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
microphthalmia 1 | 26
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 12 | 8,520
Carcinoma 9 | 11,493
malignant mesothelioma 9 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
osteosarcoma 8 | 7,950
Pick disease 7 | 1,894
active Crohn's disease 7 | 922
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
psoriasis 7 | 6,694
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
medulloblastoma, large-cell 6 | 6,241
Cataract 5 | 297
lung cancer 5 | 4,740
Antley-Bixler syndrome 4 | 16
Autosomal recessive predisposition 4 | 1,442
Cancer 4 | 2,499
Cognitive delay 4 | 608
Epilepsy 4 | 792
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Mental and motor retardation 4 | 608
Porokeratosis of Mibelli 4 | 4
Seizures 4 | 596
Small head 4 | 374
Smith-Lemli-Opitz syndrome 4 | 9
chronic rhinosinusitis 4 | 512
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
pancreatic cancer 4 | 2,398
Breast cancer 3 | 3,578
Carcinoma, Hepatocellular 3 | 228
Chagas disease 3 | 39
Congenital Epicanthus 3 | 177
Disseminated superficial actinic porokeratosis 3 | 4
Dull intelligence 3 | 645
Failure to gain weight 3 | 365
Hydrolethalus syndrome 3 | 128
Hyperkeratosis 3 | 50
Hypoplastic mandible condyle 3 | 275
Lens Opacities 3 | 231
Liver carcinoma 3 | 240
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Mevalonic aciduria 3 | 16
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Pediatric failure to thrive 3 | 365
Photosensitivity of skin 3 | 51
Poor school performance 3 | 645
Porokeratosis, Disseminated Superficial Actinic 3 | 4
Posteriorly rotated ear 3 | 61
glioblastoma 3 | 5,792
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
spina bifida 3 | 1,074
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Anteverted nostril 2 | 191
Atopic dermatitis 2 | 952
Biparietal narrowing 2 | 28
Blepharoptosis 2 | 231
Byzanthine arch palate 2 | 194
Chondrodysplasia punctata 2 | 41
Congenital deafness 2 | 185
Deafness 2 | 198
Decreased width of the skull 2 | 28
Downward slant of palpebral fissure 2 | 158
Fibular polydactyly 2 | 12
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Hearing Loss, Partial 2 | 185
Hepatomegaly 2 | 285
Hydronephrosis 2 | 89
Long philtrum 2 | 137
Low-set, posteriorly rotated ears 2 | 110
Multiple myeloma 2 | 1,332
Narrow forehead 2 | 34
Physical aggression 2 | 76
Postaxial foot polydactyly 2 | 12
Pyloric Stenosis 2 | 47
Stippled epiphyses 2 | 28
Strabismus 2 | 270
Tinea corporis 2 | 25
Tinea pedis 2 | 29
Vomiting 2 | 116
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
esophageal adenocarcinoma 2 | 737
hearing impairment 2 | 199
interstitial cystitis 2 | 2,312
lung adenocarcinoma 2 | 2,716
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 14 | 4,145
Kinase 1 | 634

WikiPathways Pathway

Cholesterol Biosynthesis 15 | 15
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Lathosterol oxidase SC5D Tbio Enzyme -1.42233 28.3 26
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109
Lanosterol synthase LSS Tchem Enzyme -2.22381 150.1 87
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Squalene monooxygenase SQLE Tchem Enzyme -1.89887 71.9 109
Methylsterol monooxygenase 1 MSMO1 Tbio Enzyme -1.64987 43.8 106
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.94323 876.8 272
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tchem Enzyme -1.60998 38.3 124