Development Level

Tbio 93 | 11,445
Tchem 51 | 1,598
Tclin 16 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 7 | 979
decreased total body fat amoun... 5 | 207
increased circulating alkaline... 5 | 122
abnormal retina morphology 4 | 71
decreased vertical activity 4 | 208
increased mean corpuscular hem... 4 | 96
thrombocytopenia 4 | 56
abnormal gait 3 | 69
decreased circulating insulin ... 3 | 76
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
improved glucose tolerance 3 | 79
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
hydrometra 2 | 53
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged RR interval 1 | 8
small kidney 1 | 16
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 99 | 11,493
ovarian cancer 95 | 8,520
Cancer 91 | 2,499
osteosarcoma 85 | 7,950
psoriasis 77 | 6,694
glioblastoma 73 | 5,792
medulloblastoma, large-cell 69 | 6,241
lung cancer 63 | 4,740
interstitial cystitis 56 | 2,312
atypical teratoid / rhabdoid tumor 55 | 5,112
lung carcinoma 55 | 2,843
Breast cancer 51 | 3,578
ependymoma 51 | 4,679
adult high grade glioma 49 | 3,801
non-small cell lung cancer 45 | 2,890
invasive ductal carcinoma 44 | 2,951
malignant mesothelioma 43 | 3,232
ulcerative colitis 41 | 1,819
lung adenocarcinoma 40 | 2,716
Kidney cancer 39 | 2,613
group 3 medulloblastoma 38 | 4,104
subependymal giant cell astrocytoma 38 | 2,287
tuberculosis 37 | 2,010
Astrocytoma, Pilocytic 34 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
oligodendroglioma 34 | 2,850
pancreatic cancer 33 | 2,398
primitive neuroectodermal tumor 33 | 3,035
cutaneous lupus erythematosus 32 | 1,057
Rheumatoid arthritis 31 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
astrocytic glioma 28 | 2,597
breast carcinoma 28 | 1,638
cystic fibrosis 28 | 1,696
Asthma 26 | 385
Pick disease 26 | 1,894
diabetes mellitus 25 | 1,728
juvenile dermatomyositis 24 | 1,187
primary Sjogren syndrome 24 | 735
ductal carcinoma in situ 23 | 1,745
Arthritis 22 | 290
Multiple Sclerosis 22 | 540
group 4 medulloblastoma 22 | 1,855
Pneumonia 21 | 174
colon cancer 21 | 1,478
Schizophrenia 20 | 1,160
astrocytoma 20 | 1,146
Autosomal recessive predisposition 19 | 1,442
Hypersensitivity 19 | 63
Liver Cirrhosis, Experimental 18 | 769
Multiple myeloma 18 | 1,332
pituitary cancer 18 | 1,972
Hypersensitivity reaction type II disease 17 | 253
Vascular disease 17 | 319
Breast Neoplasms 16 | 445
Hypertension 16 | 396
Mammary Neoplasms 16 | 425
Inflammatory bowel disease 15 | 151
Lung disease 15 | 142
Obesity 15 | 678
Prostatic Neoplasms 15 | 495
Short stature 15 | 531
active Crohn's disease 15 | 922
Bipolar Disorder 14 | 666
Depressive disorder 14 | 409
Dermatitis 14 | 157
Intellectual disability 14 | 1,016
Melanoma 14 | 711
Waldenstrons macroglobulinemia 14 | 765
active ulcerative colitis 14 | 764
dermatomyositis 14 | 966
nasopharyngeal carcinoma 14 | 1,058
primary pancreatic ductal adenocarcinoma 14 | 1,109
Acquired scoliosis 13 | 281
Atherosclerosis 13 | 291
Brain Ischemia 13 | 110
Byzanthine arch palate 13 | 194
Curvature of spine 13 | 282
Epilepsy 13 | 792
Mental Depression 13 | 333
Orbital separation excessive 13 | 244
Seizures 13 | 596
adrenocortical carcinoma 13 | 1,428
hepatocellular carcinoma 13 | 547
sarcoidosis 13 | 370
spina bifida 13 | 1,074
Blepharoptosis 12 | 231
Kidney disease 12 | 430
Liver cancer 12 | 604
Muscle hypotonia 12 | 571
gastric carcinoma 12 | 807
medulloblastoma 12 | 720
mucosa-associated lymphoid tissue lymphoma 12 | 484
pediatric high grade glioma 12 | 1,064
Dull intelligence 11 | 645
Hypoplastic mandible condyle 11 | 275
Mental deficiency 11 | 645
Poor school performance 11 | 645
periodontitis 11 | 293

Tissue

Endocrine System 164 | 18,159
Blood and immune system 163 | 16,909
Digestive Tract 163 | 17,369
Male tissues 163 | 17,142
Female tissues 162 | 17,400
Liver and Pancreas 161 | 16,750
Skin and soft tissues 161 | 17,230
Urinary Tract 161 | 16,678
Respiratory system 160 | 16,393
Nervous System 158 | 16,725
Cardiovascular System 151 | 15,192

Target Family

Non-IDG 78 | 12,091
Kinase 39 | 634
Enzyme 24 | 4,145
GPCR 16 | 408
Transcription Factor 7 | 1,400

WikiPathways Pathway

Chemokine signaling pathway 164 | 164
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
C-C motif chemokine 20 CCL20 Tbio Non-IDG -3.10283 1250.3 496
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
T-lymphoma invasion and metastasis-inducing protein 2 TIAM2 Tbio Non-IDG -1.27322 19.7 151
cAMP-dependent protein kinase catalytic subunit PRKX PRKX Tchem Kinase -1.17196 28.7 183