Development Level

Tbio 15 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal placenta size 1 | 20
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 12 | 11,493
ovarian cancer 12 | 8,520
Cancer 11 | 2,499
glioblastoma 11 | 5,792
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
lung cancer 6 | 4,740
non-small cell lung cancer 6 | 2,890
osteosarcoma 6 | 7,950
Breast cancer 5 | 3,578
Cleft Palate 5 | 271
Orbital separation excessive 5 | 244
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
Acquired scoliosis 4 | 281
Astrocytoma, Pilocytic 4 | 3,081
Concave bridge of nose 4 | 195
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Rheumatoid arthritis 4 | 1,191
Uranostaphyloschisis 4 | 167
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
nasopharyngeal carcinoma 4 | 1,058
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Cryptorchidism 3 | 296
Epilepsy 3 | 792
Frontal bossing 3 | 157
Heart disease 3 | 306
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Osteoporosis 3 | 363
Prostatic Neoplasms 3 | 495
Seizures 3 | 596
Short stature 3 | 531
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
chronic lymphosyte leukemia 3 | 204
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819
Arthritis, Juvenile 2 | 126
Atopic dermatitis 2 | 952
Breast Neoplasms 2 | 445
Broad forehead 2 | 59
Byzanthine arch palate 2 | 194
Chronic otitis media 2 | 52
Congenital deafness 2 | 185
Congenital heart disease 2 | 93
Craniosynostosis 2 | 74
Deafness 2 | 198
Delayed speech and language development 2 | 112
Depressive disorder 2 | 409
Flexion contracture of proximal interphalangeal joint 2 | 75
Hearing Loss, Partial 2 | 185
Hypoplasia of corpus callosum 2 | 90
Juvenile arthritis 2 | 126
Kidney disease 2 | 430
Language Delay 2 | 112
Mammary Neoplasms 2 | 425
Myopathy 2 | 185
Parkinson's disease 2 | 392
Prostate cancer 2 | 175
Recurrent respiratory infections 2 | 141
Short philtrum 2 | 53
Speech Delay 2 | 112
Speech impairment 2 | 112
Strabismus 2 | 270
Visceral heterotaxy 2 | 14
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
ear infection chronic 2 | 52
esophageal adenocarcinoma 2 | 737
hearing impairment 2 | 199
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
mucosa-associated lymphoid tissue lymphoma 2 | 484
tuberculosis 2 | 2,010

Tissue

Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Nervous System 16 | 16,725
Blood and immune system 15 | 16,909
Female tissues 15 | 17,400
Male tissues 15 | 17,142
Skin and soft tissues 15 | 17,230
Cardiovascular System 14 | 15,192
Liver and Pancreas 14 | 16,750
Respiratory system 13 | 16,393
Urinary Tract 13 | 16,678

Target Family

Transcription Factor 14 | 1,400
Epigenetic 2 | 242
Non-IDG 2 | 12,091

WikiPathways Pathway

Cell Differentiation - Index e... 18 | 18
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
T-cell leukemia homeobox protein 2 TLX2 Tbio Transcription Factor -2.18879 155.8 57
T-cell leukemia homeobox protein 3 TLX3 Tbio Transcription Factor -1.71132 52.4 122
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
T-cell leukemia homeobox protein 1 TLX1 Tbio Transcription Factor -2.11926 139.7 99
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
Paired box protein Pax-7 PAX7 Tbio Transcription Factor -2.70703 468.7 418
Myoblast determination protein 1 MYOD1 Tbio Transcription Factor -3.16910 1355.7 632
Transcription factor SOX-2 SOX2 Tbio Transcription Factor -3.20671 1563.0 1171
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520