Development Level

Tbio 58 | 11,445
Tchem 31 | 1,598
Tclin 12 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 8 | 278
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
abnormal lens morphology 3 | 81
cataract 3 | 92
small testis 3 | 58
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
decreased circulating glucose ... 2 | 126
edema 2 | 59
female infertility 2 | 60
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating insulin ... 1 | 76
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased body weight 1 | 25
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small kidney 1 | 16
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
urinary bladder obstruction 1 | 4

Disease

Cancer 75 | 2,499
ovarian cancer 74 | 8,520
Carcinoma 72 | 11,493
medulloblastoma, large-cell 67 | 6,241
lung cancer 65 | 4,740
glioblastoma 64 | 5,792
osteosarcoma 62 | 7,950
psoriasis 62 | 6,694
atypical teratoid / rhabdoid tumor 59 | 5,112
Breast cancer 58 | 3,578
group 3 medulloblastoma 58 | 4,104
malignant mesothelioma 56 | 3,232
primitive neuroectodermal tumor 49 | 3,035
adult high grade glioma 44 | 3,801
non-small cell lung cancer 43 | 2,890
lung adenocarcinoma 42 | 2,716
adrenocortical carcinoma 41 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
ependymoma 33 | 4,679
colon cancer 31 | 1,478
invasive ductal carcinoma 31 | 2,951
nasopharyngeal carcinoma 28 | 1,058
pancreatic cancer 28 | 2,398
breast carcinoma 27 | 1,638
ductal carcinoma in situ 27 | 1,745
Endometriosis 26 | 540
oligodendroglioma 24 | 2,850
Astrocytoma, Pilocytic 22 | 3,081
Kidney cancer 22 | 2,613
Atopic dermatitis 20 | 952
Multiple myeloma 19 | 1,332
Small head 18 | 374
Schizophrenia 17 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Prostatic Neoplasms 16 | 495
astrocytoma 16 | 1,146
ulcerative colitis 16 | 1,819
Intellectual disability 15 | 1,016
acute quadriplegic myopathy 15 | 1,158
astrocytic glioma 15 | 2,597
tuberculosis 15 | 2,010
Breast Neoplasms 14 | 445
Short stature 14 | 531
interstitial cystitis 14 | 2,312
pediatric high grade glioma 14 | 1,064
subependymal giant cell astrocytoma 14 | 2,287
Autosomal recessive predisposition 13 | 1,442
Mammary Neoplasms 13 | 425
Melanoma 13 | 711
Stomach Neoplasms 13 | 300
Waldenstrons macroglobulinemia 13 | 765
dermatomyositis 13 | 966
Carcinoma, Hepatocellular 12 | 228
Cognitive delay 12 | 608
Dull intelligence 12 | 645
Global developmental delay 12 | 608
Liver carcinoma 12 | 240
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Poor school performance 12 | 645
diabetes mellitus 12 | 1,728
juvenile dermatomyositis 12 | 1,187
primary Sjogren syndrome 12 | 735
Bladder Neoplasm 11 | 112
Fetal Growth Retardation 11 | 189
Infant, Small for Gestational Age 11 | 176
Intrauterine retardation 11 | 176
Pancreatic Neoplasm 11 | 85
Primary cutaneous T-cell lymphoma 11 | 29
Urinary Bladder Neoplasms 11 | 114
Adenoma 10 | 167
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Pick disease 10 | 1,894
medulloblastoma 10 | 720
Ataxia telangiectasia 9 | 34
Carcinoma, Squamous Cell 9 | 110
Epilepsy 9 | 792
Glaucoma 9 | 239
Low set ears 9 | 181
Lung Neoplasms 9 | 232
Pancreatic Neoplasms 9 | 85
Peripheral T-cell lymphoma 9 | 25
Rheumatoid arthritis 9 | 1,191
Seizures 9 | 596
Squamous cell carcinoma 9 | 129
group 4 medulloblastoma 9 | 1,855
Bipolar Disorder 8 | 666
Colonic Neoplasms 8 | 142
Immune system cancer 8 | 140
Liver Cirrhosis, Experimental 8 | 769
Mental Depression 8 | 333
active Crohn's disease 8 | 922
esophageal adenocarcinoma 8 | 737
lung carcinoma 8 | 2,843
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Blood and immune system 102 | 16,909
Digestive Tract 102 | 17,369
Endocrine System 102 | 18,159
Female tissues 102 | 17,400
Liver and Pancreas 102 | 16,750
Male tissues 102 | 17,142
Nervous System 102 | 16,725
Respiratory system 102 | 16,393
Skin and soft tissues 102 | 17,230
Urinary Tract 101 | 16,678
Cardiovascular System 97 | 15,192

Target Family

Non-IDG 54 | 12,091
Kinase 17 | 634
Enzyme 14 | 4,145
Transcription Factor 10 | 1,400
Epigenetic 9 | 242

WikiPathways Pathway

Cell Cycle 104 | 104
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
TBC1 domain family member 8 TBC1D8 Tdark Non-IDG 0.21 0.48 69
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
G2/mitotic-specific cyclin-B3 CCNB3 Tbio Non-IDG -1.07824 12.1 272
Putative pituitary tumor-transforming gene 3 protein PTTG3P Tdark Non-IDG 0.00000 0