Development Level

Tchem 32 | 1,388
Tclin 11 | 612
Tbio 10 | 11,651

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating sodium l... 2 | 22
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased leukocyte cell numbe... 2 | 47
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
shortened RR interval 1 | 17
thrombocytosis 1 | 27

Disease

Cancer 41 | 2,499
Carcinoma 40 | 11,493
glioblastoma 34 | 5,792
ovarian cancer 31 | 8,520
osteosarcoma 29 | 7,950
ependymoma 25 | 4,679
lung cancer 22 | 4,740
medulloblastoma, large-cell 22 | 6,241
atypical teratoid / rhabdoid tumor 21 | 5,112
adult high grade glioma 20 | 3,801
Breast cancer 19 | 3,578
Schizophrenia 19 | 1,160
Kidney cancer 17 | 2,613
diabetes mellitus 17 | 1,728
Astrocytoma, Pilocytic 16 | 3,081
Depressive disorder 16 | 409
psoriasis 16 | 6,694
malignant mesothelioma 15 | 3,232
subependymal giant cell astrocytoma 15 | 2,287
group 3 medulloblastoma 14 | 4,104
group 4 medulloblastoma 14 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
oligodendroglioma 14 | 2,850
Kidney disease 13 | 430
Mental Depression 13 | 333
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Heart disease 12 | 306
Lung Neoplasms 12 | 232
Vascular disease 12 | 319
primitive neuroectodermal tumor 12 | 3,035
Arthritis 11 | 290
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
Multiple myeloma 11 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
tuberculosis 11 | 2,010
Alzheimer's disease 10 | 658
Bipolar Disorder 10 | 666
Intellectual disability 10 | 1,016
Prostatic Neoplasms 10 | 495
astrocytic glioma 10 | 2,597
Cardiomegaly 9 | 116
Hypertensive disease 9 | 292
Lung disease 9 | 142
Obesity 9 | 678
Short stature 9 | 531
Toxic encephalopathy 9 | 141
cystic fibrosis 9 | 1,696
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
Acquired scoliosis 8 | 281
Coronary artery disease 8 | 268
Curvature of spine 8 | 282
Dull intelligence 8 | 645
Heart failure 8 | 162
Hyperglycemia 8 | 137
Hypertension 8 | 396
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Neoplasm Metastasis 8 | 168
Osteoporosis 8 | 363
Parkinson's disease 8 | 392
Poor school performance 8 | 645
interstitial cystitis 8 | 2,312
lung adenocarcinoma 8 | 2,716
lung carcinoma 8 | 2,843
Adenocarcinoma 7 | 122
Asthma 7 | 385
Autosomal recessive predisposition 7 | 1,442
Byzanthine arch palate 7 | 194
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Hyperalgesia 7 | 83
Hypoplastic mandible condyle 7 | 275
Inflammatory bowel disease 7 | 151
Liver Cirrhosis, Experimental 7 | 769
Major Depressive Disorder 7 | 301
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Mood Disorders 7 | 184
Myocardial Ischemia 7 | 169
Neoplasm Invasiveness 7 | 161
Orbital separation excessive 7 | 244
Seizures 7 | 596
Unipolar Depression 7 | 250
astrocytoma 7 | 1,146
juvenile dermatomyositis 7 | 1,187
primary pancreatic ductal adenocarcinoma 7 | 1,109
ulcerative colitis 7 | 1,819
Brain Ischemia 6 | 110
Cerebrovascular disease 6 | 238
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Pick disease 6 | 1,894
Polycystic ovary syndrome 6 | 360
acute quadriplegic myopathy 6 | 1,158

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Nervous System 53 | 16,725
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Female tissues 52 | 17,400
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Respiratory system 52 | 16,393
Cardiovascular System 51 | 15,192

Target Family

Kinase 34 | 634
Non-IDG 8 | 12,091
Enzyme 4 | 4,145
Epigenetic 4 | 242
Transcription Factor 3 | 1,400

WikiPathways Pathway

Cardiac Hypertrophic Response 53 | 53
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.70325 459.4 238
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Natriuretic peptides A NPPA Tchem Non-IDG -3.25145 1788.9 509
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440