Development Level

Tchem 34 | 1,890
Tclin 11 | 602
Tbio 8 | 10,625

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating LDL chol... 2 | 37
decreased circulating sodium l... 2 | 18
decreased lean body mass 2 | 195
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
preweaning lethality, incomple... 2 | 260
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating free fat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 35
thrombocytosis 1 | 23

Disease

Cancer 40 | 2,346
glioblastoma 31 | 5,572
ovarian cancer 31 | 8,491
osteosarcoma 29 | 7,933
medulloblastoma, large-cell 22 | 6,234
atypical teratoid / rhabdoid tumor 20 | 4,369
lung cancer 19 | 4,473
Breast cancer 18 | 3,098
diabetes mellitus 17 | 1,663
pilocytic astrocytoma 17 | 3,086
psoriasis 16 | 6,685
ependymoma 15 | 2,514
subependymal giant cell astrocytoma 15 | 2,287
Carcinoma 14 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
oligodendroglioma 14 | 2,849
Kidney disease 13 | 397
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
malignant mesothelioma 13 | 3,163
Heart disease 12 | 279
Vascular disease 12 | 281
group 4 medulloblastoma 12 | 1,875
pediatric high grade glioma 12 | 2,712
primitive neuroectodermal tumor 12 | 3,031
Alzheimer's disease 11 | 644
Lung Neoplasms 11 | 171
Multiple myeloma 11 | 1,327
adult high grade glioma 11 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
medulloblastoma 11 | 1,524
Arthritis 10 | 248
Mammary Neoplasms 10 | 410
Obesity 10 | 616
Prostatic Neoplasms 10 | 471
tuberculosis 10 | 1,563
ulcerative colitis 10 | 2,087
Lung disease 9 | 136
astrocytic glioma 9 | 2,241
cystic fibrosis 9 | 1,670
non-small cell lung cancer 9 | 2,798
Heart failure 8 | 80
Neoplasm Metastasis 8 | 138
Toxic encephalopathy 8 | 131
astrocytoma 8 | 1,493
interstitial cystitis 8 | 2,299
lung adenocarcinoma 8 | 2,714
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
Adenocarcinoma 7 | 115
Asthma 7 | 349
Cardiomegaly 7 | 66
Myocardial Ischemia 7 | 169
Neoplasm Invasiveness 7 | 127
Osteoporosis 7 | 259
Parkinson's disease 7 | 364
Schizophrenia 7 | 503
juvenile dermatomyositis 7 | 1,189
primary pancreatic ductal adenocarcinoma 7 | 1,271
Brain Ischemia 6 | 87
Cleft palate 6 | 125
Colorectal Neoplasms 6 | 217
Coronary artery disease 6 | 240
Hyperalgesia 6 | 71
Hyperglycemia 6 | 120
Inflammatory bowel disease 6 | 142
Intellectual disability 6 | 573
Neoplastic Cell Transformation 6 | 81
Pick disease 6 | 1,893
Pulmonary Fibrosis 6 | 66
acute quadriplegic myopathy 6 | 1,157
group 3 medulloblastoma 6 | 2,254
posterior fossa group A ependymoma 6 | 1,511
posterior fossa group B ependymoma 6 | 1,530
Acute kidney injury 5 | 65
Brain disease 5 | 84
Cardiomyopathies 5 | 90
Cocaine-Related Disorders 5 | 88
Diabetes Mellitus, Experimental 5 | 106
Diabetes Mellitus, Non-Insulin-Dependent 5 | 161
Diabetic Retinopathy 5 | 53
Diaphragmatic Hernia 5 | 40
Endometriosis 5 | 535
Hypertension 5 | 293
Hypertensive disease 5 | 193
Liver Cirrhosis 5 | 101
Liver disease 5 | 219
Melanoma 5 | 261
Metabolic syndrome X 5 | 155
Multiple Sclerosis 5 | 498
Nerve Degeneration 5 | 73
Pain 5 | 70
Peripheral Neuropathy 5 | 303
Reperfusion Injury 5 | 84
Rheumatoid Arthritis 5 | 1,170
Stomach Neoplasms 5 | 282
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Waldenstrons macroglobulinemia 4 | 764
aldosterone-producing adenoma 4 | 664
pituitary cancer 4 | 1,972
spina bifida 4 | 1,064

Tissue

Blood and immune system 53 | 17,994
Cardiovascular System 53 | 17,957
Digestive Tract 53 | 18,472
Endocrine System 53 | 18,511
Female tissues 53 | 18,646
Liver and Pancreas 53 | 18,135
Male tissues 53 | 17,968
Nervous System 53 | 18,560
Urinary Tract 53 | 18,443
Respiratory system 52 | 17,483
Skin and soft tissues 51 | 18,114

Target Family

Kinase 34 | 634
Non-IDG 8 | 11,969
Enzyme 4 | 4,146
Epigenetic 4 | 242
Transcription Factor 3 | 1,400

WikiPathways Pathway

Cardiac Hypertrophic Response 53 | 53
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.67695 418.8 220
Natriuretic peptides A NPPA Tchem Non-IDG -3.23922 1719.8 429
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -1.97989 67.5 582
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.09190 1147.5 1943
Protein kinase C alpha type PRKCA Tchem Kinase -2.39992 212.2 774
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tbio Kinase -2.09381 110.8 261
Dual specificity mitogen-activated protein kinase kinase 5 MAP2K5 Tchem Kinase -1.86736 59.4 368