Development Level

Tchem 9 | 1,885
Tbio 8 | 11,178

IMPC Phenotype

abnormal sleep behavior 1 | 70
convulsive seizures 1 | 13
increased body length 1 | 32
increased fasted circulating g... 1 | 76

Disease

Cancer 13 | 2,388
Carcinoma 13 | 11,192
ovarian cancer 13 | 8,297
Astrocytoma, Pilocytic 12 | 3,006
glioblastoma 12 | 5,635
osteosarcoma 12 | 7,766
Breast cancer 11 | 3,469
atypical teratoid / rhabdoid tumor 11 | 4,971
adult high grade glioma 10 | 3,701
ependymoma 10 | 4,559
pancreatic cancer 9 | 2,322
psoriasis 9 | 6,514
group 3 medulloblastoma 8 | 4,002
medulloblastoma, large-cell 8 | 6,086
Hypertensive disease 7 | 278
malignant mesothelioma 7 | 3,135
primitive neuroectodermal tumor 7 | 2,957
Increase in blood pressure 6 | 118
Liver Cirrhosis, Experimental 6 | 733
lung cancer 6 | 4,607
Aortic Valve Insufficiency 5 | 39
Coronary artery disease 5 | 253
Craniofacial Abnormalities 5 | 141
Kidney cancer 5 | 2,548
Kidney disease 5 | 411
Pulmonary Fibrosis 5 | 101
Vascular disease 5 | 294
cystic fibrosis 5 | 1,629
interstitial cystitis 5 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
non-small cell lung cancer 5 | 2,799
primary pancreatic ductal adenocarcinoma 5 | 1,071
subependymal giant cell astrocytoma 5 | 2,230
ulcerative colitis 5 | 1,765
Abnormality of the iris 4 | 14
Acquired scoliosis 4 | 274
Aortic aneurysm 4 | 33
Aortic aneurysm, familial thoracic 3 4 | 13
Arthritis 4 | 276
Ascending aortic dissection 4 | 13
Cardiomegaly 4 | 114
Chest Pain 4 | 38
Colorectal Neoplasms 4 | 235
Curvature of spine 4 | 275
Cutis marmorata 4 | 31
Cystic medial necrosis of aorta 4 | 13
Descending aortic dissection 4 | 13
Duchenne muscular dystrophy 4 | 587
Dyspnea on exertion 4 | 24
Dyspnea, Paroxysmal 4 | 13
Familial thoracic aortic aneurysm and aortic dissection 4 | 13
Hereditary hemorrhagic telangiectasia 4 | 13
Impaired left ventricular function 4 | 16
Left-Sided Heart Failure 4 | 16
Liver Cirrhosis 4 | 173
Liver disease 4 | 227
Loeys-Dietz Aortic Aneurysm Syndrome 4 | 13
Loeys-Dietz syndrome 4 | 22
Orbital separation excessive 4 | 240
Schizophrenia 4 | 1,136
Ureteral obstruction 4 | 32
Waldenstrons macroglobulinemia 4 | 742
diabetes mellitus 4 | 1,683
gastric carcinoma 4 | 781
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,902
juvenile dermatomyositis 4 | 1,147
lung adenocarcinoma 4 | 2,627
lung carcinoma 4 | 2,755
oligodendroglioma 4 | 2,768
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
Abdominal Pain 3 | 95
Acquired flat foot 3 | 70
Adenoma 3 | 159
Arachnodactyly 3 | 49
Arterial tortuosity 3 | 5
Asthma 3 | 370
Byzanthine arch palate 3 | 194
Cell Transformation, Neoplastic 3 | 90
Cholestasis, Extrahepatic 3 | 20
Congenital Camptodactyly 3 | 39
Depressive disorder 3 | 401
Flatfoot 3 | 71
Gaucher disease type 1 3 | 177
Heart disease 3 | 288
Hepatitis C 3 | 90
Hypertension 3 | 372
Hypotrophic malar bone 3 | 129
Inflammatory bowel disease 3 | 148
Linear atrophy 3 | 15
Lung Neoplasms 3 | 217
Lung disease 3 | 135
Malar flattening 3 | 129
Neoplasm Metastasis 3 | 160
Neoplastic Cell Transformation 3 | 83
Pneumonia 3 | 169
Stomach Neoplasms 3 | 287
Systemic scleroderma 3 | 57
acute quadriplegic myopathy 3 | 1,133
astrocytic glioma 3 | 2,530
dermatomyositis 3 | 941

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Cardiovascular System 16 | 15,192

Target Family

Kinase 7 | 634
Enzyme 4 | 4,145
Non-IDG 3 | 12,091
Transcription Factor 3 | 1,400

WikiPathways Pathway

Canonical and Non-Canonical TG... 17 | 17
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gremlin-1 GREM1 Tbio Non-IDG -2.91296 826.9 397
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.35499 232.7 208
Protein-lysine 6-oxidase LOX Tbio Enzyme -3.36257 2227.1 513
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.24186 173.0 274
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548