Development Level

Tbio 17 | 11,445
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased monocyte cell number 2 | 63
abnormal eating behavior 1 | 1
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased tidal volume 1 | 1
edema 1 | 59
enlarged kidney 1 | 14
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
preweaning lethality, incomple... 1 | 499
respiratory system phenotype 1 | 2

Disease

Carcinoma 22 | 11,493
Cancer 17 | 2,499
psoriasis 15 | 6,694
glioblastoma 13 | 5,792
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
ovarian cancer 13 | 8,520
Breast Neoplasms 12 | 445
Mammary Neoplasms 11 | 425
atypical teratoid / rhabdoid tumor 11 | 5,112
Breast cancer 9 | 3,578
invasive ductal carcinoma 9 | 2,951
malignant mesothelioma 9 | 3,232
Astrocytoma, Pilocytic 8 | 3,081
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
osteosarcoma 8 | 7,950
pediatric high grade glioma 8 | 1,064
tuberculosis 8 | 2,010
Carcinoma, Pancreatic Ductal 7 | 20
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
juvenile dermatomyositis 7 | 1,187
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Alzheimer's disease 6 | 658
Kidney cancer 6 | 2,613
adult high grade glioma 6 | 3,801
breast carcinoma 6 | 1,638
gastric carcinoma 6 | 807
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
Brachydactyly 5 | 156
Dementia 5 | 175
Failure to gain weight 5 | 365
Liver cancer 5 | 604
Lung Neoplasms 5 | 232
Pediatric failure to thrive 5 | 365
Schizophrenia 5 | 1,160
Short distal phalanges 5 | 50
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
Adenoid Cystic Carcinoma 4 | 99
Alagille syndrome 4 | 15
Cadasil 4 | 10
Carcinoma, Adenoid Cystic 4 | 99
Carcinoma, Squamous Cell 4 | 110
Cataract 4 | 297
Cerebrovascular disease 4 | 238
Duchenne muscular dystrophy 4 | 601
Hydrocephalus 4 | 152
Lens Opacities 4 | 231
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
Skin Neoplasms 4 | 69
Strabismus 4 | 270
Tetralogy of Fallot 4 | 63
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
Abnormality of pulmonary valve 3 | 23
Acquired scoliosis 3 | 281
Amyloidosis 3 | 67
Amyotrophic lateral sclerosis 3 | 451
Aplasia Cutis Congenita 3 | 14
Bipolar Disorder 3 | 666
Colonic Neoplasms 3 | 142
Congenital scar 3 | 13
Craniofacial Abnormalities 3 | 151
Curvature of spine 3 | 282
Down syndrome 3 | 499
Esophageal Squamous Cell Carcinoma 3 | 77
Hypertension 3 | 396
Long narrow head 3 | 75
Narrow cranium shape 3 | 75
Narrow head shape 3 | 75
Narrow skull shape 3 | 75
Skin cancer 3 | 469
Sparse hair 3 | 59
Spondylocostal dysostosis 3 | 12
Squamous cell carcinoma of esophagus 3 | 77
Syndactyly of fingers 3 | 48
Thin, sparse hair 3 | 59
Turridolichocephaly 3 | 75
Uterine Cervical Neoplasm 3 | 25
Uterine Cervical Neoplasms 3 | 26
inflammatory breast cancer 3 | 286
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
progressive supranuclear palsy 3 | 676
sonic hedgehog group medulloblastoma 3 | 467
ulcerative colitis 3 | 1,819
urothelial carcinoma 3 | 318

Tissue

Endocrine System 27 | 18,159
Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Female tissues 26 | 17,400
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Urinary Tract 26 | 16,678
Cardiovascular System 25 | 15,192
Liver and Pancreas 25 | 16,750
Skin and soft tissues 25 | 17,230

Target Family

Non-IDG 18 | 12,091
Enzyme 4 | 4,145
Transcription Factor 4 | 1,400
Kinase 1 | 634

WikiPathways Pathway

Canonical and Non-canonical N... 27 | 27
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Contactin-6 CNTN6 Tbio Non-IDG -2.09155 109.6 79
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.65805 49.1 185
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.64652 422.4 384
Ras-related protein R-Ras RRAS Tbio Enzyme -2.15870 149.8 150
Microfibrillar-associated protein 2 MFAP2 Tbio Non-IDG -1.84472 72.8 129
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Neurogenic locus notch homolog protein 4 NOTCH4 Tchem Non-IDG -2.75010 557.0 225