Development Level

Tchem 5 | 1,598
Tbio 2 | 11,445
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
decreased mean platelet volume 1 | 25
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydroencephaly 1 | 14
increased circulating LDL chol... 1 | 13
increased mean corpuscular hem... 1 | 96
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979

Disease

diabetes mellitus 7 | 1,728
Cancer 6 | 2,499
Carcinoma 6 | 11,493
Obesity 6 | 678
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
Hyperglycemia 5 | 137
Kidney disease 5 | 430
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
glioblastoma 5 | 5,792
Alzheimer's disease 4 | 658
Anemia 4 | 365
Arthritis 4 | 290
Atherosclerosis 4 | 291
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Diabetes Mellitus, Experimental 4 | 108
Fatty liver disease 4 | 103
Hypertension 4 | 396
Mammary Neoplasms 4 | 425
Parkinson's disease 4 | 392
Prostatic Neoplasms 4 | 495
Toxic encephalopathy 4 | 141
Vascular disease 4 | 319
astrocytic glioma 4 | 2,597
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Abnormality of metabolism/homeostasis 3 | 134
Acute kidney injury 3 | 70
Adenoma 3 | 167
Amyotrophic lateral sclerosis 3 | 451
Bipolar Disorder 3 | 666
Brain disease 3 | 96
Carcinoma, squamous cell of head and neck 3 | 31
Colitis 3 | 54
Colorectal Neoplasms 3 | 243
Demyelinating Diseases 3 | 7
Depressive disorder 3 | 409
Diabetic retinopathy 3 | 56
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Heart disease 3 | 306
Hypertensive disease 3 | 292
Intellectual disability 3 | 1,016
Liver disease 3 | 237
Lung disease 3 | 142
Muscular atrophy 3 | 71
Neoplasm Metastasis 3 | 168
Nerve Degeneration 3 | 121
Neurofibromatosis 3 | 40
Polycystic ovary syndrome 3 | 360
Renal Cell Carcinoma 3 | 214
Skin Neoplasms 3 | 69
Skin disease 3 | 66
breast carcinoma 3 | 1,638
ependymoma 3 | 4,679
interstitial lung disease 3 | 298
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 1,819
Alcoholic Intoxication 2 | 34
Autistic Disorder 2 | 364
Bladder Neoplasm 2 | 112
Blepharoptosis 2 | 231
Carcinoma, Hepatocellular 2 | 228
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Heart failure 2 | 162
Huntington's disease 2 | 76
Hyperandrogenism 2 | 34
Hyperinsulinism 2 | 133
Hypothyroidism 2 | 122
Inflammatory bowel disease 2 | 151
Large intestine cancer 2 | 126
Leukopenia 2 | 72
Lipid metabolism disorder 2 | 114
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Mood Disorders 2 | 184
Mouth Neoplasms 2 | 55
Myocardial Infarction 2 | 151
Myopathy 2 | 185
Neurodegenerative Disorders 2 | 79
Neurodegenerative disease 2 | 414
Osteoporosis 2 | 363
Pituitary adenoma 2 | 38
Seizures 2 | 596
Skin cancer 2 | 469
Somatic mutation 2 | 61
Squamous cell carcinoma 2 | 129
Stomach Neoplasms 2 | 300
Thrombocytopenia 2 | 197
Urinary Bladder Neoplasms 2 | 114
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Enzyme 2 | 4,145
Kinase 2 | 634
Non-IDG 2 | 12,091
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

WikiPathways Pathway

Caloric restriction and aging 8 | 8
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
5'-AMP-activated protein kinase subunit beta-2 PRKAB2 Tchem Enzyme -0.79676 5.52 170
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.50639 3413.7 733
Insulin-like growth factor I IGF1 Tbio Non-IDG -4.32790 22748.0 913
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPARGC1A Tbio Non-IDG -2.86449 728.1 274