Development Level

Tchem 13 | 1,598
Tbio 10 | 11,445
Tclin 9 | 613

IMPC Phenotype

abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating insulin ... 2 | 76
enlarged heart 2 | 210
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased leukocyte cell numbe... 1 | 73
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
increased body weight 1 | 25
increased bone mineral content 1 | 108
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Cancer 27 | 2,499
Carcinoma 27 | 11,493
ovarian cancer 25 | 8,520
lung cancer 23 | 4,740
glioblastoma 22 | 5,792
atypical teratoid / rhabdoid tumor 20 | 5,112
osteosarcoma 20 | 7,950
Breast cancer 19 | 3,578
psoriasis 19 | 6,694
medulloblastoma, large-cell 18 | 6,241
malignant mesothelioma 17 | 3,232
pancreatic cancer 15 | 2,398
Breast Neoplasms 14 | 445
Lung Neoplasms 14 | 232
Mammary Neoplasms 14 | 425
Stomach Neoplasms 14 | 300
Adenoma 12 | 167
Bladder Neoplasm 12 | 112
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
Neoplasm Metastasis 12 | 168
Prostatic Neoplasms 12 | 495
Urinary Bladder Neoplasms 12 | 114
ependymoma 12 | 4,679
oligodendroglioma 12 | 2,850
Adenocarcinoma 11 | 122
Astrocytoma, Pilocytic 11 | 3,081
Carcinoma, Non-Small-Cell Lung 11 | 107
Kidney cancer 11 | 2,613
Melanoma 11 | 711
Stomach cancer 11 | 30
adult high grade glioma 11 | 3,801
interstitial cystitis 11 | 2,312
invasive ductal carcinoma 11 | 2,951
non-small cell lung carcinoma 11 | 317
primitive neuroectodermal tumor 11 | 3,035
Carcinoma, Squamous Cell 10 | 110
Squamous cell carcinoma 10 | 129
ductal carcinoma in situ 10 | 1,745
group 3 medulloblastoma 10 | 4,104
Animal Mammary Neoplasms 9 | 136
Autosomal recessive predisposition 9 | 1,442
Colonic Neoplasms 9 | 142
Colorectal Neoplasms 9 | 243
Mammary Neoplasms, Animal 9 | 136
Papilloma 9 | 44
Vascular disease 9 | 319
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
diabetes mellitus 9 | 1,728
non-small cell lung cancer 9 | 2,890
ulcerative colitis 9 | 1,819
Blepharoptosis 8 | 231
Cell Transformation, Neoplastic 8 | 97
Immune system cancer 8 | 140
Lymphoid leukemia 8 | 160
Mammary Neoplasms, Experimental 8 | 154
Neoplasms, Experimental 8 | 40
Neoplastic Cell Transformation 8 | 89
Pancreatic Neoplasm 8 | 85
Pancreatic Neoplasms 8 | 85
lung adenocarcinoma 8 | 2,716
nasopharyngeal carcinoma 8 | 1,058
pituitary cancer 8 | 1,972
subependymal giant cell astrocytoma 8 | 2,287
Cognitive delay 7 | 608
DOID:2627 7 | 94
Dull intelligence 7 | 645
Endometriosis 7 | 540
Esophageal Squamous Cell Carcinoma 7 | 77
Frontal bossing 7 | 157
Global developmental delay 7 | 608
Hypertrophic Cardiomyopathy 7 | 117
Intellectual disability 7 | 1,016
Liver Neoplasms, Experimental 7 | 59
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Neoplasm Invasiveness 7 | 161
Orbital separation excessive 7 | 244
Poor school performance 7 | 645
Precancerous Conditions 7 | 80
Renal Cell Carcinoma 7 | 214
Schizophrenia 7 | 1,160
Short stature 7 | 531
Skin cancer 7 | 469
Squamous cell carcinoma of esophagus 7 | 77
Upper respiratory tract disease 7 | 15
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
hepatocellular carcinoma 7 | 547
juvenile dermatomyositis 7 | 1,187
tuberculosis 7 | 2,010
Epilepsy 6 | 792
colon cancer 6 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung carcinoma 6 | 2,843

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192

Target Family

Kinase 13 | 634
Non-IDG 9 | 12,091
Enzyme 7 | 4,145
Transcription Factor 3 | 1,400

WikiPathways Pathway

Bladder Cancer 32 | 32
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Death-associated protein kinase 2 DAPK2 Tchem Kinase -1.39206 28.7 440
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Death-associated protein kinase 3 DAPK3 Tchem Kinase -1.64668 50.7 291
Fibroblast growth factor receptor 3 FGFR3 Tclin Kinase -3.00731 1050.1 479
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Cadherin-1 CDH1 Tbio Non-IDG -3.85201 6324.3 1880
Death-associated protein kinase 1 DAPK1 Tchem Kinase -2.34153 226.1 276
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705