Development Level

Tchem 16 | 1,388
Tbio 13 | 11,651
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
increased lean body mass 2 | 172
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
abnormal rib morphology 1 | 10
corneal vascularization 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
tremors 1 | 39

Disease

Carcinoma 29 | 11,493
Cancer 24 | 2,499
ovarian cancer 21 | 8,520
atypical teratoid / rhabdoid tumor 20 | 5,112
osteosarcoma 19 | 7,950
glioblastoma 18 | 5,792
lung cancer 17 | 4,740
ependymoma 15 | 4,679
medulloblastoma, large-cell 15 | 6,241
psoriasis 15 | 6,694
Epilepsy 14 | 792
group 3 medulloblastoma 14 | 4,104
Intellectual disability 13 | 1,016
Kidney cancer 13 | 2,613
adult high grade glioma 13 | 3,801
Schizophrenia 12 | 1,160
subependymal giant cell astrocytoma 12 | 2,287
Breast cancer 11 | 3,578
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 9 | 3,081
Autistic Disorder 9 | 364
Bipolar Disorder 9 | 666
Pick disease 9 | 1,894
Seizures 9 | 596
astrocytoma 9 | 1,146
non-small cell lung cancer 9 | 2,890
oligodendroglioma 9 | 2,850
pancreatic cancer 9 | 2,398
Alzheimer's disease 8 | 658
Blepharoptosis 8 | 231
Cognitive delay 8 | 608
Downward slant of palpebral fissure 8 | 158
Global developmental delay 8 | 608
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Mental and motor retardation 8 | 608
Micrognathism 8 | 275
Short stature 8 | 531
astrocytic glioma 8 | 2,597
lung adenocarcinoma 8 | 2,716
Byzanthine arch palate 7 | 194
Cocaine-Related Disorders 7 | 92
Cryptorchidism 7 | 296
Depressive disorder 7 | 409
Electroencephalogram abnormal 7 | 101
Major Depressive Disorder 7 | 301
Melanoma 7 | 711
Noonan syndrome 7 | 34
Obesity 7 | 678
Orbital separation excessive 7 | 244
Parkinson's disease 7 | 392
Toxic encephalopathy 7 | 141
Unipolar Depression 7 | 250
Vascular disease 7 | 319
diabetes mellitus 7 | 1,728
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 7 | 1,187
Acquired scoliosis 6 | 281
Alcoholic Intoxication, Chronic 6 | 289
Big calvaria 6 | 147
Cafe au lait spots, multiple 6 | 17
Carcinoma, Squamous Cell 6 | 110
Concave bridge of nose 6 | 195
Curly hair (finding) 6 | 14
Curvature of spine 6 | 282
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Fibrous skin tumor of tuberous sclerosis 6 | 18
Hemangioma, Cavernous 6 | 20
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Kyphoscoliosis deformity of spine 6 | 60
Mental Depression 6 | 333
Muscle hypotonia 6 | 571
Neck webbing 6 | 35
Pectus excavatum 6 | 100
Renal Cell Carcinoma 6 | 214
Sebaceous adenoma 6 | 26
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
Strabismus 6 | 270
ulcerative colitis 6 | 1,819
Attention deficit hyperactivity disorder 5 | 278
Carcinoma, Hepatocellular 5 | 228
Congenital Epicanthus 5 | 177
Delayed bone age 5 | 136
Endometrial cancer 5 | 311
Liver carcinoma 5 | 240
Lung Neoplasms 5 | 232
Mood Disorders 5 | 184
Skin cancer 5 | 469
Ventricular Septal Defects 5 | 119
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 12 | 12,091
Kinase 11 | 634
Enzyme 6 | 4,145
Ion Channel 3 | 344
Transcription Factor 1 | 1,400

WikiPathways Pathway

BDNF-TrkB Signaling 33 | 33
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217
Homer protein homolog 1 HOMER1 Tbio Non-IDG -2.45026 285.7 241
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.33582 220.9 1431
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Activity-regulated cytoskeleton-associated protein ARC Tbio Non-IDG -2.30664 188.9 176
Hamartin TSC1 Tbio Non-IDG -2.25451 173.9 1622
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147