Development Level

Tbio 42 | 10,625
Tchem 42 | 1,890
Tclin 12 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

decreased body weight 5 | 174
preweaning lethality, complete... 5 | 633
abnormal lens morphology 3 | 73
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
increased startle reflex 2 | 38
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 30
absent vibrissae 1 | 14
cataract 1 | 26
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased lumbar vertebrae num... 1 | 62
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased leukocyte cell numbe... 1 | 37
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small testis 1 | 37
tremors 1 | 34

Disease

osteosarcoma 71 | 7,933
Cancer 59 | 2,346
ovarian cancer 57 | 8,491
glioblastoma 44 | 5,572
psoriasis 42 | 6,685
lung cancer 39 | 4,473
medulloblastoma, large-cell 36 | 6,234
subependymal giant cell astrocytoma 32 | 2,287
ulcerative colitis 29 | 2,087
interstitial cystitis 28 | 2,299
atypical teratoid / rhabdoid tumor 27 | 4,369
Carcinoma 25 | 2,147
lung carcinoma 25 | 2,844
oligodendroglioma 24 | 2,849
pediatric high grade glioma 24 | 2,712
pilocytic astrocytoma 24 | 3,086
primary Sjogren syndrome 24 | 788
astrocytoma 22 | 1,493
invasive ductal carcinoma 22 | 2,950
ependymoma 21 | 2,514
diabetes mellitus 20 | 1,663
primitive neuroectodermal tumor 19 | 3,031
Rheumatoid Arthritis 18 | 1,170
non-small cell lung cancer 18 | 2,798
tuberculosis 18 | 1,563
Breast cancer 17 | 3,098
group 4 medulloblastoma 17 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
Multiple myeloma 16 | 1,327
Pick disease 16 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
group 3 medulloblastoma 15 | 2,254
juvenile dermatomyositis 15 | 1,189
malignant mesothelioma 15 | 3,163
medulloblastoma 15 | 1,524
Waldenstrons macroglobulinemia 14 | 764
colon cancer 14 | 1,475
cutaneous lupus erythematosus 14 | 1,056
Vascular disease 13 | 281
adult high grade glioma 13 | 2,148
astrocytic glioma 13 | 2,241
dermatomyositis 13 | 966
lung adenocarcinoma 13 | 2,714
pancreatic cancer 13 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
acute myeloid leukemia 11 | 785
Alzheimer's disease 10 | 644
ductal carcinoma in situ 10 | 1,745
nasopharyngeal carcinoma 10 | 1,056
pituitary cancer 10 | 1,972
primary pancreatic ductal adenocarcinoma 10 | 1,271
Arthritis 9 | 248
Lung Neoplasms 9 | 171
Multiple Sclerosis 9 | 498
cystic fibrosis 9 | 1,670
periodontitis 9 | 269
spina bifida 9 | 1,064
Kidney disease 8 | 397
Noonan Syndrome 8 | 33
Parkinson's disease 8 | 364
Schizophrenia 8 | 503
acute quadriplegic myopathy 8 | 1,157
chronic lymphocytic leukemia 8 | 244
gastric carcinoma 8 | 832
Acquired immunodeficiency syndrome 7 | 164
Blastic phase chronic myeloid leukemia 7 | 58
Chronic Myelocytic Leukemia Accelerated Phase 7 | 59
Heart disease 7 | 279
IGA Glomerulonephritis 7 | 454
Intellectual disability 7 | 573
Lung disease 7 | 136
Melanoma 7 | 261
Neoplastic Cell Transformation 7 | 81
Obesity 7 | 616
Stomach Neoplasms 7 | 282
breast carcinoma 7 | 1,614
non primary Sjogren syndrome sicca 7 | 840
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
posterior fossa group B ependymoma 7 | 1,530
progressive supranuclear palsy 7 | 674
Adult T-Cell Lymphoma/Leukemia 6 | 30
Asthma 6 | 349
Brain Ischemia 6 | 87
Cardiofaciocutaneous syndrome 6 | 15
Common variable immunodeficiency 6 | 98
Costello Syndrome 6 | 18
Diffuse large B-cell lymphoma 6 | 42
LEOPARD Syndrome 6 | 20
Liver neoplasms 6 | 108
Mammary Neoplasms 6 | 410
Renal Cell Carcinoma 6 | 199
Reperfusion Injury 6 | 84
Sezary Syndrome 6 | 26
atypical teratoid/rhabdoid tumor 6 | 1,095
esophageal adenocarcinoma 6 | 737
tuberculosis and treatment for 6 months 6 | 686
Down syndrome 5 | 548
aldosterone-producing adenoma 5 | 664
nephrosclerosis 5 | 329

Tissue

Blood and immune system 97 | 17,994
Cardiovascular System 97 | 17,957
Digestive Tract 97 | 18,472
Endocrine System 97 | 18,511
Female tissues 97 | 18,646
Liver and Pancreas 97 | 18,135
Male tissues 97 | 17,968
Nervous System 97 | 18,560
Respiratory system 97 | 17,483
Urinary Tract 97 | 18,443
Skin and soft tissues 95 | 18,114

Target Family

Kinase 35 | 634
Non-IDG 27 | 11,969
Transcription Factor 20 | 1,400
Enzyme 15 | 4,146

WikiPathways Pathway

B Cell Receptor Signaling Path... 97 | 97
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Proto-oncogene vav VAV1 Tchem Non-IDG -2.64007 465.9 479
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.99634 1000.8 1343
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.12968 129.2 231
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -1.97989 67.5 582
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395