Development Level

Tbio 46 | 11,445
Tchem 38 | 1,598
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 5 | 161
increased total body fat amoun... 3 | 134
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged kidney 1 | 14
hydrometra 1 | 53
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 81 | 11,493
osteosarcoma 71 | 7,950
Cancer 60 | 2,499
ovarian cancer 57 | 8,520
glioblastoma 46 | 5,792
lung cancer 43 | 4,740
psoriasis 42 | 6,694
medulloblastoma, large-cell 36 | 6,241
ependymoma 32 | 4,679
subependymal giant cell astrocytoma 32 | 2,287
Kidney cancer 30 | 2,613
atypical teratoid / rhabdoid tumor 30 | 5,112
group 3 medulloblastoma 28 | 4,104
interstitial cystitis 28 | 2,312
adult high grade glioma 26 | 3,801
lung carcinoma 25 | 2,843
oligodendroglioma 24 | 2,850
Breast cancer 23 | 3,578
primary Sjogren syndrome 23 | 735
ulcerative colitis 23 | 1,819
Astrocytoma, Pilocytic 22 | 3,081
invasive ductal carcinoma 22 | 2,951
tuberculosis 21 | 2,010
diabetes mellitus 20 | 1,728
Rheumatoid arthritis 19 | 1,191
primitive neuroectodermal tumor 19 | 3,035
Multiple myeloma 18 | 1,332
astrocytoma 18 | 1,146
non-small cell lung cancer 18 | 2,890
Autosomal recessive predisposition 17 | 1,442
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Immunologic Deficiency Syndromes 16 | 113
Pick disease 16 | 1,894
group 4 medulloblastoma 16 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
malignant mesothelioma 16 | 3,232
Schizophrenia 15 | 1,160
juvenile dermatomyositis 15 | 1,187
Arthritis 14 | 290
Melanoma 14 | 711
Vascular disease 14 | 319
Waldenstrons macroglobulinemia 14 | 765
colon cancer 14 | 1,478
cutaneous lupus erythematosus 14 | 1,057
pancreatic cancer 14 | 2,398
Short stature 13 | 531
dermatomyositis 13 | 966
lung adenocarcinoma 13 | 2,716
Orbital separation excessive 12 | 244
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Chronic otitis media 11 | 52
Intellectual disability 11 | 1,016
Liver Cirrhosis, Experimental 11 | 769
acute myeloid leukemia 11 | 783
ear infection chronic 11 | 52
pediatric high grade glioma 11 | 1,064
Agammaglobulinemia 10 | 34
Alzheimer's disease 10 | 658
Blepharoptosis 10 | 231
Cognitive delay 10 | 608
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Diarrhea 10 | 253
Downward slant of palpebral fissure 10 | 158
Failure to gain weight 10 | 365
Fever 10 | 138
Global developmental delay 10 | 608
Hepatomegaly 10 | 285
Hypoplastic mandible condyle 10 | 275
Increased susceptibility to bacterial infections 10 | 42
Infantile onset 10 | 238
Mandibular hypoplasia 10 | 275
Mental and motor retardation 10 | 608
Micrognathism 10 | 275
Muscle hypotonia 10 | 571
Obesity 10 | 678
Pediatric failure to thrive 10 | 365
Prone to bacterial infection 10 | 42
Recurrent bacterial infection 10 | 42
ductal carcinoma in situ 10 | 1,745
nasopharyngeal carcinoma 10 | 1,058
pituitary cancer 10 | 1,972
primary pancreatic ductal adenocarcinoma 10 | 1,109
Byzanthine arch palate 9 | 194
Chronic Lymphocytic Leukemia 9 | 262
Curvature of spine 9 | 282
Dull intelligence 9 | 645
Epilepsy 9 | 792
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Seizures 9 | 596
Splenomegaly 9 | 190
Strabismus 9 | 270
cystic fibrosis 9 | 1,696
periodontitis 9 | 293
spina bifida 9 | 1,074

Tissue

Blood and immune system 97 | 16,909
Cardiovascular System 97 | 15,192
Digestive Tract 97 | 17,369
Endocrine System 97 | 18,159
Female tissues 97 | 17,400
Liver and Pancreas 97 | 16,750
Male tissues 97 | 17,142
Respiratory system 97 | 16,393
Skin and soft tissues 97 | 17,230
Urinary Tract 97 | 16,678
Nervous System 96 | 16,725

Target Family

Kinase 35 | 634
Non-IDG 27 | 12,091
Transcription Factor 20 | 1,400
Enzyme 15 | 4,145

WikiPathways Pathway

B Cell Receptor Signaling Path... 97 | 97
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733