Development Level

Tbio 34 | 10,625
Tchem 21 | 1,890
Tclin 9 | 602
Tdark 2 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 3 | 260
abnormal epididymis morphology 2 | 31
abnormal testis morphology 2 | 30
decreased bone mineral content 2 | 157
decreased circulating insulin ... 2 | 75
enlarged epididymis 2 | 27
increased blood urea nitrogen ... 2 | 44
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal lumbar vertebrae morp... 1 | 6
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating fructosa... 1 | 31
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
fused cornea and lens 1 | 4
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased fasted circulating g... 1 | 68
microphthalmia 1 | 15
prenatal lethality 1 | 16

Disease

ovarian cancer 44 | 8,484
Cancer 40 | 2,346
osteosarcoma 36 | 7,933
glioblastoma 32 | 5,572
psoriasis 30 | 6,685
atypical teratoid / rhabdoid tumor 29 | 4,369
medulloblastoma, large-cell 28 | 6,234
lung cancer 26 | 4,466
Breast cancer 23 | 3,094
Carcinoma 20 | 2,147
oligodendroglioma 20 | 2,849
primitive neuroectodermal tumor 18 | 3,031
ependymoma 17 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
pilocytic astrocytoma 17 | 3,086
Pick disease 16 | 1,893
lung carcinoma 16 | 2,844
pediatric high grade glioma 15 | 2,712
subependymal giant cell astrocytoma 15 | 2,287
astrocytic glioma 14 | 2,241
invasive ductal carcinoma 14 | 2,950
Lung Neoplasms 13 | 171
diabetes mellitus 13 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
malignant mesothelioma 13 | 3,162
medulloblastoma 13 | 1,524
non-small cell lung cancer 13 | 2,798
Mammary Neoplasms 12 | 410
Vascular disease 12 | 281
acute quadriplegic myopathy 12 | 1,157
astrocytoma 12 | 1,493
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
pancreatic cancer 12 | 2,300
tuberculosis 12 | 1,557
Prostatic Neoplasms 11 | 471
Rheumatoid Arthritis 11 | 1,160
Stomach Neoplasms 11 | 282
ductal carcinoma in situ 11 | 1,745
primary pancreatic ductal adenocarcinoma 11 | 1,271
Multiple myeloma 10 | 1,327
adult high grade glioma 10 | 2,148
group 3 medulloblastoma 10 | 2,254
interstitial cystitis 10 | 2,299
pituitary cancer 10 | 1,972
Alzheimer's disease 9 | 644
Colonic Neoplasms 9 | 126
Liver carcinoma 9 | 217
Parkinson's disease 9 | 364
Toxic encephalopathy 9 | 131
adrenocortical carcinoma 9 | 1,427
breast carcinoma 9 | 1,614
colon cancer 9 | 1,475
non-small cell lung carcinoma 9 | 413
spina bifida 9 | 1,064
Adenoma 8 | 165
Amyotrophic Lateral Sclerosis 8 | 431
Asthma 8 | 349
Heart disease 8 | 279
Neoplasm Invasiveness 8 | 127
cystic fibrosis 8 | 1,665
juvenile dermatomyositis 8 | 1,189
lung adenocarcinoma 8 | 2,713
ovarian neoplasm 8 | 97
posterior fossa group A ependymoma 8 | 1,511
posterior fossa group B ependymoma 8 | 1,530
ulcerative colitis 8 | 2,087
Kidney disease 7 | 396
Neurodegenerative disease 7 | 383
Osteoporosis 7 | 257
Waldenstrons macroglobulinemia 7 | 765
Bladder Neoplasm 6 | 109
Brain Ischemia 6 | 87
Duchenne muscular dystrophy 6 | 602
Liver neoplasms 6 | 109
Neoplastic Cell Transformation 6 | 81
Obesity 6 | 616
Peripheral Neuropathy 6 | 303
Schizophrenia 6 | 501
atypical teratoid/rhabdoid tumor 6 | 1,095
fibroadenoma 6 | 557
Adenocarcinoma 5 | 115
Animal Mammary Neoplasms 5 | 136
Arthritis 5 | 248
Cardiomegaly 5 | 66
Glioma 5 | 65
Kidney cancer 5 | 118
Neoplasm Metastasis 5 | 138
Nerve Degeneration 5 | 73
Reperfusion Injury 5 | 84
Squamous cell carcinoma 5 | 94
acute myeloid leukemia 5 | 780
aldosterone-producing adenoma 5 | 664
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
primary Sjogren syndrome 5 | 789
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis and treatment for 6 months 5 | 686
dermatomyositis 4 | 933
gastric carcinoma 4 | 832

Tissue

Blood and immune system 66 | 17,995
Cardiovascular System 66 | 17,958
Digestive Tract 66 | 18,473
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Nervous System 66 | 18,561
Respiratory system 66 | 17,484
Urinary Tract 66 | 18,444
Skin and soft tissues 65 | 18,115

Target Family

Non-IDG 25 | 11,971
Kinase 17 | 634
GPCR 10 | 406
Enzyme 9 | 4,146
Transcription Factor 4 | 1,400
Ion Channel 1 | 341

WikiPathways Pathway

Association Between Physico-Ch... 66 | 66
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Frizzled-7 FZD7 Tbio GPCR -1.70812 55.9 303
Profilin-4 PFN4 Tdark Non-IDG -0.52386 3.41 21
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Profilin-2 PFN2 Tbio Non-IDG -1.92449 89.6 196