Development Level

Tbio 36 | 11,651
Tchem 19 | 1,388
Tclin 9 | 612
Tdark 2 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 4 | 162
enlarged heart 4 | 210
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal testis morphology 2 | 43
decreased circulating insulin ... 2 | 76
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
increased blood urea nitrogen ... 2 | 48
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye size 1 | 7
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fused cornea and lens 1 | 5
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating insulin ... 1 | 3
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 50 | 11,493
ovarian cancer 45 | 8,520
Cancer 40 | 2,499
osteosarcoma 36 | 7,950
glioblastoma 34 | 5,792
atypical teratoid / rhabdoid tumor 33 | 5,112
lung cancer 30 | 4,740
psoriasis 30 | 6,694
Breast cancer 29 | 3,578
ependymoma 29 | 4,679
medulloblastoma, large-cell 28 | 6,241
Kidney cancer 24 | 2,613
oligodendroglioma 20 | 2,850
astrocytic glioma 19 | 2,597
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 18 | 4,104
primitive neuroectodermal tumor 18 | 3,035
Schizophrenia 17 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Astrocytoma, Pilocytic 16 | 3,081
Pick disease 16 | 1,894
lung carcinoma 16 | 2,843
malignant mesothelioma 16 | 3,232
non-small cell lung cancer 15 | 2,890
subependymal giant cell astrocytoma 15 | 2,287
Stomach Neoplasms 14 | 300
Vascular disease 14 | 319
invasive ductal carcinoma 14 | 2,951
pancreatic cancer 14 | 2,398
tuberculosis 14 | 2,010
Lung Neoplasms 13 | 232
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Rheumatoid arthritis 12 | 1,191
acute quadriplegic myopathy 12 | 1,158
group 4 medulloblastoma 12 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Depressive disorder 11 | 409
Prostatic Neoplasms 11 | 495
breast carcinoma 11 | 1,638
ductal carcinoma in situ 11 | 1,745
Alzheimer's disease 10 | 658
Bipolar Disorder 10 | 666
Multiple myeloma 10 | 1,332
Toxic encephalopathy 10 | 141
interstitial cystitis 10 | 2,312
pituitary cancer 10 | 1,972
Amyotrophic lateral sclerosis 9 | 451
Carcinoma, Hepatocellular 9 | 228
Colonic Neoplasms 9 | 142
Heart disease 9 | 306
Liver carcinoma 9 | 240
Parkinson's disease 9 | 392
Renal Cell Carcinoma 9 | 214
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
primary pancreatic ductal adenocarcinoma 9 | 1,109
spina bifida 9 | 1,074
Adenoma 8 | 167
Asthma 8 | 385
Cognitive delay 8 | 608
Disease Models, Animal 8 | 155
Global developmental delay 8 | 608
Hypertension 8 | 396
Kidney disease 8 | 430
Melanoma 8 | 711
Mental and motor retardation 8 | 608
Neoplasm Invasiveness 8 | 161
Nerve Degeneration 8 | 121
Ovarian Neoplasms 8 | 102
Skin cancer 8 | 469
astrocytoma 8 | 1,146
cystic fibrosis 8 | 1,696
juvenile dermatomyositis 8 | 1,187
lung adenocarcinoma 8 | 2,716
ovarian neoplasm 8 | 99
ulcerative colitis 8 | 1,819
Autosomal recessive predisposition 7 | 1,442
Cell Transformation, Neoplastic 7 | 97
Hypertensive disease 7 | 292
Intellectual disability 7 | 1,016
Liver neoplasms 7 | 130
Mental Depression 7 | 333
Neoplastic Cell Transformation 7 | 89
Neurodegenerative disease 7 | 414
Orbital separation excessive 7 | 244
Osteoporosis 7 | 363
Pectus excavatum 7 | 100
Waldenstrons macroglobulinemia 7 | 765
medulloblastoma 7 | 720
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Duchenne muscular dystrophy 6 | 601
acute myeloid leukemia 6 | 783
fibroadenoma 6 | 559
hepatocellular carcinoma 6 | 547

Tissue

Endocrine System 65 | 18,159
Digestive Tract 64 | 17,369
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Skin and soft tissues 64 | 17,230
Blood and immune system 63 | 16,909
Female tissues 63 | 17,400
Urinary Tract 63 | 16,678
Liver and Pancreas 61 | 16,750
Respiratory system 60 | 16,393
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 25 | 12,091
Kinase 17 | 634
GPCR 10 | 408
Enzyme 9 | 4,145
Transcription Factor 4 | 1,400
Ion Channel 1 | 344

WikiPathways Pathway

Association Between Physico-Ch... 66 | 66
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Protransforming growth factor alpha TGFA Tbio Non-IDG -2.15761 135.3 697
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.28334 17.7 202
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859
Frizzled-1 FZD1 Tbio GPCR -2.07049 78.4 286
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307