Development Level

Tbio 34 | 11,178
Tchem 21 | 1,885
Tclin 9 | 612
Tdark 2 | 6,569

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 4 | 162
enlarged heart 4 | 210
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal testis morphology 2 | 43
decreased circulating insulin ... 2 | 76
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
increased blood urea nitrogen ... 2 | 48
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye size 1 | 7
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fused cornea and lens 1 | 5
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating insulin ... 1 | 3
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 50 | 11,192
ovarian cancer 45 | 8,297
Cancer 40 | 2,388
osteosarcoma 36 | 7,766
glioblastoma 34 | 5,635
atypical teratoid / rhabdoid tumor 32 | 4,971
lung cancer 30 | 4,607
psoriasis 30 | 6,514
Breast cancer 29 | 3,469
ependymoma 28 | 4,559
medulloblastoma, large-cell 27 | 6,086
Kidney cancer 24 | 2,548
oligodendroglioma 20 | 2,768
astrocytic glioma 18 | 2,530
Schizophrenia 17 | 1,136
adult high grade glioma 17 | 3,701
group 3 medulloblastoma 17 | 4,002
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,872
primitive neuroectodermal tumor 17 | 2,957
Astrocytoma, Pilocytic 16 | 3,006
Pick disease 16 | 1,856
lung carcinoma 16 | 2,755
malignant mesothelioma 16 | 3,135
non-small cell lung cancer 15 | 2,799
subependymal giant cell astrocytoma 15 | 2,230
Stomach Neoplasms 14 | 287
Vascular disease 14 | 294
pancreatic cancer 14 | 2,322
Lung Neoplasms 13 | 217
diabetes mellitus 13 | 1,683
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,902
invasive ductal carcinoma 13 | 2,867
tuberculosis 13 | 1,963
Breast Neoplasms 12 | 423
Mammary Neoplasms 12 | 403
acute quadriplegic myopathy 12 | 1,133
group 4 medulloblastoma 12 | 1,806
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,204
Depressive disorder 11 | 401
Prostatic Neoplasms 11 | 472
Rheumatoid arthritis 11 | 1,156
breast carcinoma 11 | 1,589
Alzheimer's disease 10 | 640
Bipolar Disorder 10 | 646
Multiple myeloma 10 | 1,296
Toxic encephalopathy 10 | 139
ductal carcinoma in situ 10 | 1,686
interstitial cystitis 10 | 2,237
pituitary cancer 10 | 1,915
Amyotrophic lateral sclerosis 9 | 437
Carcinoma, Hepatocellular 9 | 217
Colonic Neoplasms 9 | 133
Heart disease 9 | 288
Liver carcinoma 9 | 229
Parkinson's disease 9 | 378
Renal Cell Carcinoma 9 | 211
colon cancer 9 | 1,428
primary pancreatic ductal adenocarcinoma 9 | 1,071
spina bifida 9 | 1,053
Adenoma 8 | 159
Asthma 8 | 370
Cognitive delay 8 | 596
Disease Models, Animal 8 | 148
Global developmental delay 8 | 596
Hypertension 8 | 372
Kidney disease 8 | 411
Melanoma 8 | 689
Mental and motor retardation 8 | 596
Neoplasm Invasiveness 8 | 151
Nerve Degeneration 8 | 118
Ovarian Neoplasms 8 | 96
Skin cancer 8 | 451
adrenocortical carcinoma 8 | 1,385
astrocytoma 8 | 1,113
cystic fibrosis 8 | 1,629
juvenile dermatomyositis 8 | 1,147
lung adenocarcinoma 8 | 2,627
ovarian neoplasm 8 | 93
ulcerative colitis 8 | 1,765
Autosomal recessive predisposition 7 | 1,407
Cell Transformation, Neoplastic 7 | 90
Hypertensive disease 7 | 278
Intellectual disability 7 | 998
Liver neoplasms 7 | 126
Mental Depression 7 | 325
Neoplastic Cell Transformation 7 | 83
Neurodegenerative disease 7 | 402
Orbital separation excessive 7 | 240
Osteoporosis 7 | 348
Pectus excavatum 7 | 100
Waldenstrons macroglobulinemia 7 | 742
medulloblastoma 7 | 702
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
pediatric high grade glioma 7 | 1,035
Depressed nasal bridge 6 | 191
Depressed nasal root/bridge 6 | 191
Duchenne muscular dystrophy 6 | 587
acute myeloid leukemia 6 | 760
fibroadenoma 6 | 538
hepatocellular carcinoma 6 | 536

Tissue

Endocrine System 65 | 18,159
Digestive Tract 64 | 17,369
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Skin and soft tissues 64 | 17,230
Blood and immune system 63 | 16,909
Female tissues 63 | 17,400
Urinary Tract 63 | 16,678
Liver and Pancreas 61 | 16,750
Respiratory system 60 | 16,393
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 25 | 12,091
Kinase 17 | 634
GPCR 10 | 408
Enzyme 9 | 4,145
Transcription Factor 4 | 1,400
Ion Channel 1 | 344

WikiPathways Pathway

Association Between Physico-Ch... 66 | 66
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Calcium/calmodulin-dependent protein kinase type 1 CAMK1 Tchem Kinase -1.58278 39.5 219
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Nitric oxide synthase, brain NOS1 Tchem Enzyme -3.27741 1885.8 661
Profilin-1 PFN1 Tbio Non-IDG -2.31736 223.5 260
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Frizzled-3 FZD3 Tbio GPCR -1.76528 56.4 314
Disheveled-associated activator of morphogenesis 1 DAAM1 Tbio Non-IDG -1.45166 30.8 269