Development Level

Tbio 24 | 11,445
Tchem 16 | 1,598
Tclin 6 | 613

IMPC Phenotype

abnormal behavior 2 | 298
preweaning lethality, incomple... 2 | 499
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
male infertility 1 | 123
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

psoriasis 30 | 6,694
Carcinoma 29 | 11,493
Cancer 28 | 2,499
ovarian cancer 24 | 8,520
osteosarcoma 19 | 7,950
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
lung cancer 16 | 4,740
tuberculosis 16 | 2,010
glioblastoma 15 | 5,792
Lung Neoplasms 14 | 232
diabetes mellitus 14 | 1,728
malignant mesothelioma 14 | 3,232
medulloblastoma, large-cell 14 | 6,241
Breast cancer 13 | 3,578
Schizophrenia 12 | 1,160
pancreatic cancer 12 | 2,398
Prostatic Neoplasms 11 | 495
interstitial cystitis 11 | 2,312
Anemia 10 | 365
Rheumatoid arthritis 10 | 1,191
atypical teratoid / rhabdoid tumor 10 | 5,112
cystic fibrosis 10 | 1,696
lung carcinoma 10 | 2,843
Acute kidney injury 9 | 70
Chemical and Drug Induced Liver Injury 9 | 195
Colonic Neoplasms 9 | 142
Colorectal Neoplasms 9 | 243
Kidney disease 9 | 430
Liver Cirrhosis, Experimental 9 | 769
Stomach Neoplasms 9 | 300
acute quadriplegic myopathy 9 | 1,158
non-small cell lung cancer 9 | 2,890
Asthma 8 | 385
Diarrhea 8 | 253
Endometriosis 8 | 540
Hypertensive disease 8 | 292
Liver Cirrhosis 8 | 181
Liver carcinoma 8 | 240
Liver neoplasms 8 | 130
Multiple Sclerosis 8 | 540
Neoplasms, Experimental 8 | 40
Obesity 8 | 678
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
ulcerative colitis 8 | 1,819
Abortion, Spontaneous 7 | 109
Arthritis 7 | 290
Astrocytoma, Pilocytic 7 | 3,081
Carcinoma, Hepatocellular 7 | 228
Cholestasis 7 | 155
Contact Dermatitis 7 | 81
Dermatitis, Contact 7 | 71
Diabetes Mellitus, Experimental 7 | 108
Heart disease 7 | 306
Hyperglycemia 7 | 137
Hypertension 7 | 396
Inflammatory bowel disease 7 | 151
Kidney cancer 7 | 2,613
Liver disease 7 | 237
Lung disease 7 | 142
Major Depressive Disorder 7 | 301
Melanoma 7 | 711
Neoplasm Metastasis 7 | 168
Spontaneous abortion 7 | 113
Vascular disease 7 | 319
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
pancreatic carcinoma 7 | 562
pituitary cancer 7 | 1,972
sarcoidosis 7 | 370
Alzheimer's disease 6 | 658
Bilirubin metabolic disorder 6 | 41
Bladder Neoplasm 6 | 112
Carcinoma, Squamous Cell 6 | 110
Cardiomegaly 6 | 116
Dermatitis, Allergic Contact 6 | 67
Fever 6 | 138
Neoplasm Invasiveness 6 | 161
Osteoporosis 6 | 363
Parkinson's disease 6 | 392
Sickle Cell Anemia 6 | 53
Squamous cell carcinoma 6 | 129
Urinary Bladder Neoplasms 6 | 114
aldosterone-producing adenoma 6 | 665
cutaneous lupus erythematosus 6 | 1,057
gastric carcinoma 6 | 807
head and neck cancer and chronic obstructive pulmonary disease 6 | 239
invasive ductal carcinoma 6 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
Bipolar Disorder 5 | 666
Hypersensitivity reaction type II disease 5 | 253
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989

Tissue

Digestive Tract 46 | 17,369
Liver and Pancreas 46 | 16,750
Skin and soft tissues 45 | 17,230
Male tissues 44 | 17,142
Urinary Tract 44 | 16,678
Blood and immune system 43 | 16,909
Female tissues 43 | 17,400
Endocrine System 42 | 18,159
Nervous System 42 | 16,725
Respiratory system 41 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 15 | 4,145
Transcription Factor 8 | 1,400
Epigenetic 2 | 242
Kinase 2 | 634
Transporter 1 | 473

WikiPathways Pathway

Aryl Hydrocarbon Receptor Path... 46 | 46
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.31859 4681.5 1057
Cyclin-dependent kinase inhibitor 1B CDKN1B Tbio Enzyme -3.11753 1246.6 1886
Apoptosis regulator BAX BAX Tchem Non-IDG -2.57834 248.4 1395
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.36613 239.2 307
Transcription factor jun-B JUNB Tbio Transcription Factor -1.94092 66.8 625