Development Level

Tbio 47 | 10,625
Tchem 43 | 1,890
Tclin 2 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 633
abnormal lens morphology 2 | 73
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased lean body mass 2 | 195
hypoactivity 2 | 89
increased body weight 2 | 42
increased or absent threshold ... 2 | 128
small testis 2 | 37
abnormal coat-hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 23
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased Ly6C high monocyte n... 1 | 18
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating amylase ... 1 | 24
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
increased NK cell number 1 | 19
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
small superior vagus ganglion 1 | 20
tremors 1 | 34

Disease

Cancer 72 | 2,346
ovarian cancer 55 | 8,491
lung cancer 51 | 4,473
psoriasis 48 | 6,685
osteosarcoma 43 | 7,933
glioblastoma 40 | 5,572
medulloblastoma, large-cell 35 | 6,234
malignant mesothelioma 29 | 3,163
pancreatic cancer 29 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
lung carcinoma 26 | 2,844
pilocytic astrocytoma 25 | 3,086
ulcerative colitis 24 | 2,087
atypical teratoid / rhabdoid tumor 23 | 4,369
non-small cell lung cancer 23 | 2,798
diabetes mellitus 21 | 1,663
pediatric high grade glioma 21 | 2,712
subependymal giant cell astrocytoma 21 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
lung adenocarcinoma 20 | 2,714
Rheumatoid Arthritis 19 | 1,170
oligodendroglioma 18 | 2,849
primitive neuroectodermal tumor 18 | 3,031
tuberculosis 18 | 1,563
Vascular disease 17 | 281
adrenocortical carcinoma 17 | 1,427
cutaneous lupus erythematosus 17 | 1,056
group 4 medulloblastoma 17 | 1,875
posterior fossa group A ependymoma 17 | 1,511
invasive ductal carcinoma 16 | 2,950
Arthritis 15 | 248
colon cancer 15 | 1,475
pituitary cancer 15 | 1,972
Alzheimer's disease 14 | 644
group 3 medulloblastoma 14 | 2,254
interstitial cystitis 14 | 2,299
primary pancreatic ductal adenocarcinoma 14 | 1,271
Breast cancer 13 | 3,098
Kidney disease 13 | 397
Pick disease 13 | 1,893
Prostatic Neoplasms 13 | 471
adult high grade glioma 13 | 2,148
Brain Ischemia 12 | 87
Mammary Neoplasms 12 | 410
Stomach Neoplasms 12 | 282
astrocytoma 12 | 1,493
breast carcinoma 12 | 1,614
hepatocellular carcinoma 12 | 550
juvenile dermatomyositis 12 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
acute quadriplegic myopathy 11 | 1,157
Carcinoma 10 | 2,147
Hypersensitivity reaction type II disease 10 | 235
Liver carcinoma 10 | 217
Lung Neoplasms 10 | 171
Multiple myeloma 10 | 1,327
Renal Cell Carcinoma 10 | 199
Toxic encephalopathy 10 | 131
active Crohn's disease 10 | 918
acute myeloid leukemia 10 | 785
aldosterone-producing adenoma 10 | 664
astrocytic glioma 10 | 2,241
chronic lymphocytic leukemia 10 | 244
cystic fibrosis 10 | 1,670
ductal carcinoma in situ 10 | 1,745
gastric carcinoma 10 | 832
pancreatic carcinoma 10 | 567
Colonic Neoplasms 9 | 126
Diabetes Mellitus, Experimental 9 | 106
Esophageal Neoplasms 9 | 67
Eye disease 9 | 55
Obesity 9 | 616
ependymoma 9 | 2,514
Diabetes Mellitus, Non-Insulin-Dependent 8 | 161
Inflammatory bowel disease 8 | 142
Lung disease 8 | 136
Melanoma 8 | 261
Myocardial Reperfusion Injury 8 | 34
Pancreatic Neoplasm 8 | 79
Parkinson's disease 8 | 364
atypical teratoid/rhabdoid tumor 8 | 1,095
primary Sjogren syndrome 8 | 788
spina bifida 8 | 1,064
Adenocarcinoma 7 | 115
Asthma 7 | 349
Liver disease 7 | 219
Multiple Sclerosis 7 | 498
Neurodegenerative disease 7 | 383
Peripheral Neuropathy 7 | 303
Reperfusion Injury 7 | 84
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737
gastric cancer 7 | 436
medulloblastoma 7 | 1,524
nasopharyngeal carcinoma 7 | 1,056
Endometriosis 6 | 535
Leukemia 6 | 88
inflammatory breast cancer 6 | 404
sonic hedgehog group medulloblastoma 6 | 1,482

Tissue

Blood and immune system 91 | 17,994
Digestive Tract 91 | 18,472
Endocrine System 90 | 18,511
Female tissues 90 | 18,646
Liver and Pancreas 90 | 18,135
Male tissues 90 | 17,968
Nervous System 90 | 18,560
Respiratory system 90 | 17,483
Urinary Tract 90 | 18,443
Cardiovascular System 89 | 17,957
Skin and soft tissues 89 | 18,114

Target Family

Non-IDG 62 | 11,969
Enzyme 17 | 4,146
Kinase 9 | 634
Transcription Factor 4 | 1,400

WikiPathways Pathway

Apoptosis Modulation and Signa... 92 | 92
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calpain small subunit 1 CAPNS1 Tbio Non-IDG -2.88291 736.0 131
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.14287 1340.6 903
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.56782 368.4 441
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
Bcl-2-related ovarian killer protein BOK Tbio Non-IDG -1.58634 37.9 184
Septin-4 SEPT4 Tbio Non-IDG -2.34716 216.3 186
Death domain-associated protein 6 DAXX Tbio Non-IDG -2.30299 222.3 672
Baculoviral IAP repeat-containing protein 1 NAIP Tbio Non-IDG -2.25353 183.9 130
Tumor necrosis factor receptor superfamily member 6B TNFRSF6B Tbio Non-IDG -2.19559 198.2 182