Development Level

Tbio 47 | 11,445
Tchem 35 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
increased leukocyte cell numbe... 3 | 47
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating sodium l... 2 | 22
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
absent testes 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
small superior vagus ganglion 1 | 74

Disease

Cancer 72 | 2,499
ovarian cancer 56 | 8,520
psoriasis 50 | 6,694
lung cancer 48 | 4,740
Carcinoma 45 | 11,493
glioblastoma 44 | 5,792
osteosarcoma 44 | 7,950
medulloblastoma, large-cell 34 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
atypical teratoid / rhabdoid tumor 28 | 5,112
ependymoma 27 | 4,679
Astrocytoma, Pilocytic 26 | 3,081
malignant mesothelioma 26 | 3,232
pancreatic cancer 25 | 2,398
Breast cancer 24 | 3,578
adult high grade glioma 22 | 3,801
lung carcinoma 22 | 2,843
tuberculosis 22 | 2,010
Breast Neoplasms 20 | 445
diabetes mellitus 20 | 1,728
group 3 medulloblastoma 20 | 4,104
interstitial cystitis 20 | 2,312
non-small cell lung cancer 20 | 2,890
oligodendroglioma 20 | 2,850
primitive neuroectodermal tumor 20 | 3,035
Mammary Neoplasms 19 | 425
cutaneous lupus erythematosus 19 | 1,057
invasive ductal carcinoma 19 | 2,951
juvenile dermatomyositis 19 | 1,187
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
subependymal giant cell astrocytoma 18 | 2,287
ulcerative colitis 18 | 1,819
lung adenocarcinoma 17 | 2,716
Alzheimer's disease 16 | 658
Lung Neoplasms 16 | 232
Schizophrenia 16 | 1,160
adrenocortical carcinoma 16 | 1,428
breast carcinoma 16 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
pituitary cancer 16 | 1,972
Hypersensitivity reaction type II disease 15 | 253
Liver carcinoma 15 | 240
Vascular disease 15 | 319
colon cancer 15 | 1,478
Brain Ischemia 14 | 110
Carcinoma, Hepatocellular 14 | 228
Pick disease 14 | 1,894
Prostatic Neoplasms 14 | 495
Rheumatoid arthritis 14 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Arthritis 13 | 290
Autosomal recessive predisposition 13 | 1,442
Colonic Neoplasms 13 | 142
Multiple myeloma 13 | 1,332
Stomach Neoplasms 13 | 300
acute quadriplegic myopathy 13 | 1,158
group 4 medulloblastoma 13 | 1,855
hepatocellular carcinoma 13 | 547
Liver Cirrhosis, Experimental 12 | 769
Splenomegaly 12 | 190
astrocytic glioma 12 | 2,597
cystic fibrosis 12 | 1,696
Amyotrophic lateral sclerosis 11 | 451
Diabetes Mellitus, Type 2 11 | 142
Inflammatory bowel disease 11 | 151
Kidney disease 11 | 430
Obesity 11 | 678
Pancreatic Neoplasm 11 | 85
ductal carcinoma in situ 11 | 1,745
Bipolar Disorder 10 | 666
Diabetes Mellitus, Experimental 10 | 108
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Kidney cancer 10 | 2,613
Liver disease 10 | 237
Melanoma 10 | 711
Multiple Sclerosis 10 | 540
Pancreatic Neoplasms 10 | 85
Polycystic ovary syndrome 10 | 360
dermatomyositis 10 | 966
pediatric high grade glioma 10 | 1,064
Adenocarcinoma 9 | 122
Adenoma 9 | 167
Anemia 9 | 365
Atopic dermatitis 9 | 952
Cell Transformation, Neoplastic 9 | 97
Colorectal Neoplasms 9 | 243
Hyperglycemia 9 | 137
Intellectual disability 9 | 1,016
Lung disease 9 | 142
Lymphoma 9 | 81
Neoplastic Cell Transformation 9 | 89
Skin Neoplasms 9 | 69
Toxic encephalopathy 9 | 141
acute myeloid leukemia 9 | 783
astrocytoma 9 | 1,146
nasopharyngeal carcinoma 9 | 1,058
pancreatic carcinoma 9 | 562
primary Sjogren syndrome 9 | 735
primary pancreatic ductal adenocarcinoma 9 | 1,109
Chronic Lymphocytic Leukemia 8 | 262

Tissue

Blood and immune system 84 | 16,909
Digestive Tract 84 | 17,369
Endocrine System 84 | 18,159
Respiratory system 84 | 16,393
Female tissues 83 | 17,400
Nervous System 83 | 16,725
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Liver and Pancreas 82 | 16,750
Male tissues 82 | 17,142
Cardiovascular System 79 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 15 | 4,145
Transcription Factor 14 | 1,400
Kinase 10 | 634

WikiPathways Pathway

Apoptosis 86 | 86
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Death domain-containing protein CRADD CRADD Tbio Non-IDG -1.34614 23.0 400
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Tumor necrosis factor receptor superfamily member 25 TNFRSF25 Tbio Non-IDG -3.25237 1888.2 535
Perforin-1 PRF1 Tchem Non-IDG -3.20526 1546.3 367
Caspase-4 CASP4 Tchem Enzyme -2.19377 147.3 520
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Bcl-2-related ovarian killer protein BOK Tbio Non-IDG -1.64193 42.6 207