Development Level

Tchem 74 | 1,885
Tbio 45 | 11,178
Tclin 13 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
abnormal lens morphology 4 | 81
decreased circulating LDL chol... 4 | 38
decreased circulating creatini... 4 | 39
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
cataract 3 | 92
decreased circulating choleste... 3 | 93
decreased mean corpuscular vol... 3 | 79
increased circulating HDL chol... 3 | 80
increased mean corpuscular hem... 3 | 96
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
anophthalmia 2 | 33
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged spleen 2 | 41
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating amylase ... 2 | 25
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal thymus morphology 1 | 7
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased glycosylated hemoglo... 1 | 1
increased heart left ventricle... 1 | 4
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 108 | 11,192
ovarian cancer 77 | 8,297
osteosarcoma 67 | 7,766
psoriasis 61 | 6,514
Cancer 60 | 2,388
medulloblastoma, large-cell 55 | 6,086
glioblastoma 53 | 5,635
atypical teratoid / rhabdoid tumor 48 | 4,971
lung cancer 46 | 4,607
Kidney cancer 38 | 2,548
ependymoma 36 | 4,559
Breast cancer 35 | 3,469
diabetes mellitus 35 | 1,683
adult high grade glioma 33 | 3,701
group 3 medulloblastoma 30 | 4,002
malignant mesothelioma 30 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,204
primitive neuroectodermal tumor 27 | 2,957
Obesity 26 | 655
subependymal giant cell astrocytoma 26 | 2,230
group 4 medulloblastoma 25 | 1,806
Schizophrenia 24 | 1,136
astrocytic glioma 24 | 2,530
invasive ductal carcinoma 24 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,872
lung carcinoma 23 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,902
oligodendroglioma 22 | 2,768
Pick disease 20 | 1,856
non-small cell lung cancer 20 | 2,799
tuberculosis 20 | 1,963
ductal carcinoma in situ 19 | 1,686
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,911
Astrocytoma, Pilocytic 18 | 3,006
Hyperglycemia 18 | 134
Vascular disease 18 | 294
breast carcinoma 18 | 1,589
juvenile dermatomyositis 18 | 1,147
pancreatic cancer 18 | 2,322
interstitial cystitis 17 | 2,237
Epilepsy 16 | 775
Liver carcinoma 16 | 229
lung adenocarcinoma 16 | 2,627
Carcinoma, Hepatocellular 15 | 217
Cognitive delay 15 | 596
Global developmental delay 15 | 596
Intellectual disability 15 | 998
Mental and motor retardation 15 | 596
acute quadriplegic myopathy 15 | 1,133
adrenocortical carcinoma 15 | 1,385
astrocytoma 15 | 1,113
pituitary cancer 15 | 1,915
Fatty liver disease 14 | 102
Orbital separation excessive 14 | 240
Renal Cell Carcinoma 14 | 211
active ulcerative colitis 14 | 736
Autosomal recessive predisposition 13 | 1,407
Muscle hypotonia 13 | 562
Prostatic Neoplasms 13 | 472
Rheumatoid arthritis 13 | 1,156
Seizures 13 | 584
Short stature 13 | 514
Alzheimer's disease 12 | 640
Breast Neoplasms 12 | 423
Concave bridge of nose 12 | 191
Depressed nasal bridge 12 | 191
Depressed nasal root/bridge 12 | 191
Dull intelligence 12 | 634
Hyperinsulinism 12 | 128
Hypothyroidism 12 | 115
Insulin Resistance 12 | 70
Lipid metabolism disorder 12 | 111
Low intelligence 12 | 634
Mammary Neoplasms 12 | 403
Mental Retardation 12 | 634
Mental deficiency 12 | 634
Poor school performance 12 | 634
cystic fibrosis 12 | 1,629
dermatomyositis 12 | 941
primary pancreatic ductal adenocarcinoma 12 | 1,071
ulcerative colitis 12 | 1,765
Byzanthine arch palate 11 | 194
Downward slant of palpebral fissure 11 | 158
Stomach Neoplasms 11 | 287
colon cancer 11 | 1,428
Acquired scoliosis 10 | 274
Atherosclerosis 10 | 276
Bipolar Disorder 10 | 646
Blepharoptosis 10 | 229
Cardiomyopathies 10 | 109
Cholestasis 10 | 154
Curvature of spine 10 | 275
Liver Cirrhosis, Experimental 10 | 733
Lung Neoplasms 10 | 217
Parkinson's disease 10 | 378
Pectus excavatum 10 | 100
Polycystic ovary syndrome 10 | 348
Hypoplastic mandible condyle 9 | 273
Mandibular hypoplasia 9 | 273
Micrognathism 9 | 273

Tissue

Digestive Tract 131 | 17,369
Endocrine System 131 | 18,159
Female tissues 131 | 17,400
Skin and soft tissues 130 | 17,230
Liver and Pancreas 129 | 16,750
Male tissues 129 | 17,142
Nervous System 128 | 16,725
Blood and immune system 127 | 16,909
Urinary Tract 127 | 16,678
Cardiovascular System 125 | 15,192
Respiratory system 123 | 16,393

Target Family

Kinase 69 | 634
Non-IDG 26 | 12,091
Enzyme 22 | 4,145
Transporter 6 | 473
Transcription Factor 5 | 1,400
Nuclear Receptor 4 | 48

WikiPathways Pathway

Angiopoietin Like Protein 8 Re... 132 | 132
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Mitogen-activated protein kinase kinase kinase 9 MAP3K9 Tchem Kinase -1.42881 24.7 265
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.65839 4688.0 397
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Rho-related GTP-binding protein RhoQ RHOQ Tbio Enzyme -1.48059 28.3 111
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tbio Kinase -2.12399 119.4 334
Misshapen-like kinase 1 MINK1 Tchem Kinase -2.10181 122.3 178