Development Level

Tchem 75 | 1,890
Tbio 45 | 10,625
Tclin 12 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
decreased body weight 5 | 174
preweaning lethality, incomple... 5 | 260
decreased circulating LDL chol... 4 | 37
decreased circulating creatini... 4 | 31
decreased total body fat amoun... 4 | 186
embryonic lethality prior to t... 4 | 187
abnormal lens morphology 3 | 73
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating fructosa... 2 | 31
decreased circulating glycerol... 2 | 19
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to o... 2 | 148
enlarged spleen 2 | 26
increased bone mineral density 2 | 52
increased circulating LDL chol... 2 | 15
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
absent heartbeat 1 | 6
anophthalmia 1 | 20
cataract 1 | 26
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating aspartat... 1 | 27
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating sodium l... 1 | 71
increased effector memory T-he... 1 | 5
increased glycosylated hemoglo... 1 | 1
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased memory-marker gamma-... 1 | 2
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased spleen weight 1 | 3
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
shortened RR interval 1 | 19
small superior vagus ganglion 1 | 20
straub tail 1 | 26
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 76 | 8,484
osteosarcoma 67 | 7,933
psoriasis 60 | 6,685
Cancer 58 | 2,346
medulloblastoma, large-cell 55 | 6,234
glioblastoma 51 | 5,572
atypical teratoid / rhabdoid tumor 44 | 4,369
lung cancer 41 | 4,466
diabetes mellitus 35 | 1,663
Carcinoma 33 | 2,147
Breast cancer 31 | 3,094
Obesity 28 | 616
malignant mesothelioma 28 | 3,162
ependymoma 27 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
primitive neuroectodermal tumor 27 | 3,031
group 4 medulloblastoma 26 | 1,875
subependymal giant cell astrocytoma 26 | 2,287
invasive ductal carcinoma 24 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
lung carcinoma 23 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
oligodendroglioma 22 | 2,849
pediatric high grade glioma 22 | 2,712
astrocytic glioma 21 | 2,241
Pick disease 20 | 1,893
non-small cell lung cancer 20 | 2,798
adult high grade glioma 19 | 2,148
ductal carcinoma in situ 19 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
pilocytic astrocytoma 19 | 3,086
Vascular disease 18 | 281
juvenile dermatomyositis 18 | 1,189
tuberculosis 18 | 1,557
Hyperglycemia 17 | 120
Metabolic syndrome X 17 | 155
astrocytoma 17 | 1,493
interstitial cystitis 17 | 2,299
breast carcinoma 16 | 1,614
lung adenocarcinoma 16 | 2,713
medulloblastoma 16 | 1,524
pancreatic cancer 16 | 2,300
Liver carcinoma 15 | 217
acute quadriplegic myopathy 15 | 1,157
adrenocortical carcinoma 15 | 1,427
pituitary cancer 15 | 1,972
ulcerative colitis 15 | 2,087
group 3 medulloblastoma 14 | 2,254
Fatty liver disease 13 | 84
Prostatic Neoplasms 13 | 471
Alzheimer's disease 12 | 644
Renal Cell Carcinoma 12 | 199
Rheumatoid Arthritis 12 | 1,160
dermatomyositis 12 | 933
primary pancreatic ductal adenocarcinoma 12 | 1,271
Hyperinsulinism 11 | 63
Intellectual disability 11 | 573
Lipid metabolism disorder 11 | 102
Mammary Neoplasms 11 | 410
Schizophrenia 11 | 501
active ulcerative colitis 11 | 477
colon cancer 11 | 1,475
cystic fibrosis 11 | 1,665
Stomach Neoplasms 10 | 282
posterior fossa group A ependymoma 10 | 1,511
Atherosclerosis 9 | 275
Blastic phase chronic myeloid leukemia 9 | 58
Cardiomyopathies 9 | 90
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Insulin Resistance 9 | 48
Lung Neoplasms 9 | 171
Parkinson's disease 9 | 364
active Crohn's disease 9 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
sonic hedgehog group medulloblastoma 9 | 1,482
Cholestasis 8 | 93
Diabetes Mellitus, Non-Insulin-Dependent 8 | 157
Heart disease 8 | 279
Kidney disease 8 | 396
Multiple myeloma 8 | 1,327
cutaneous lupus erythematosus 8 | 1,056
posterior fossa group B ependymoma 8 | 1,530
progressive supranuclear palsy 8 | 674
Diabetes Mellitus, Experimental 7 | 106
Epilepsy 7 | 346
Hypothyroidism 7 | 89
Noonan Syndrome 7 | 33
Polycystic Ovary Syndrome 7 | 332
Squamous cell carcinoma 7 | 94
Toxic encephalopathy 7 | 131
ovarian neoplasm 7 | 97
spina bifida 7 | 1,064
tuberculosis and treatment for 6 months 7 | 686
Arthritis 6 | 248
Atopic dermatitis 6 | 944
Endometriosis 6 | 535
acute myeloid leukemia 6 | 780
nephrosclerosis 6 | 329
non primary Sjogren syndrome sicca 6 | 840
primary Sjogren syndrome 6 | 789

Tissue

Blood and immune system 132 | 17,995
Digestive Tract 132 | 18,473
Endocrine System 132 | 18,512
Female tissues 132 | 18,647
Liver and Pancreas 132 | 18,136
Nervous System 132 | 18,561
Cardiovascular System 131 | 17,958
Urinary Tract 131 | 18,444
Male tissues 130 | 17,969
Skin and soft tissues 130 | 18,115
Respiratory system 129 | 17,484

Target Family

Kinase 69 | 634
Non-IDG 26 | 11,971
Enzyme 22 | 4,146
Transporter 6 | 473
Transcription Factor 5 | 1,400
Nuclear Receptor 4 | 48

WikiPathways Pathway

Angiopoietin Like Protein 8 Re... 132 | 132
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Sestrin-3 SESN3 Tbio Non-IDG -1.01398 10.1 137
Mitogen-activated protein kinase 13 MAPK13 Tchem Kinase -2.46715 317.1 405
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722