Development Level

Tchem 11 | 1,598
Tclin 8 | 613
Tbio 5 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
decreased circulating aspartat... 1 | 34
embryonic lethality prior to t... 1 | 278
increased hematocrit 1 | 46
limb grasping 1 | 41
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Cancer 23 | 2,499
Carcinoma 20 | 11,493
ovarian cancer 19 | 8,520
glioblastoma 16 | 5,792
Breast cancer 15 | 3,578
lung cancer 15 | 4,740
osteosarcoma 15 | 7,950
psoriasis 14 | 6,694
Kidney cancer 11 | 2,613
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
invasive ductal carcinoma 11 | 2,951
Schizophrenia 10 | 1,160
Vascular disease 10 | 319
cystic fibrosis 10 | 1,696
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Arthritis 9 | 290
Bipolar Disorder 9 | 666
Breast Neoplasms 9 | 445
Kidney disease 9 | 430
Mammary Neoplasms 9 | 425
atypical teratoid / rhabdoid tumor 9 | 5,112
breast carcinoma 9 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
malignant mesothelioma 9 | 3,232
medulloblastoma, large-cell 9 | 6,241
Diabetic retinopathy 8 | 56
Heart disease 8 | 306
Prostatic Neoplasms 8 | 495
Stomach Neoplasms 8 | 300
Carcinoma, Squamous Cell 7 | 110
Depressive disorder 7 | 409
Hypertension 7 | 396
Liver Cirrhosis 7 | 181
Renal Cell Carcinoma 7 | 214
Skin cancer 7 | 469
Squamous cell carcinoma 7 | 129
adult high grade glioma 7 | 3,801
ductal carcinoma in situ 7 | 1,745
ependymoma 7 | 4,679
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
Alzheimer's disease 6 | 658
Liver Cirrhosis, Experimental 6 | 769
Lung disease 6 | 142
Melanoma 6 | 711
Neoplasm Invasiveness 6 | 161
Seizures 6 | 596
astrocytic glioma 6 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
lung carcinoma 6 | 2,843
Astrocytoma, Pilocytic 5 | 3,081
Atherosclerosis 5 | 291
Cardiomegaly 5 | 116
Cerebrovascular disease 5 | 238
Colorectal Neoplasms 5 | 243
Coronary artery disease 5 | 268
Dull intelligence 5 | 645
Endometriosis 5 | 540
Epilepsy 5 | 792
Hemangioma 5 | 69
Hemangiosarcoma 5 | 18
Inflammation 5 | 120
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Lung Neoplasms 5 | 232
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple, subcutaneous nodules 5 | 53
Myocardial Ischemia 5 | 169
Neoplasm Metastasis 5 | 168
Poor school performance 5 | 645
Skin Neoplasms 5 | 69
Subcutaneous nodule 5 | 53
adrenocortical carcinoma 5 | 1,428
group 3 medulloblastoma 5 | 4,104
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
juvenile dermatomyositis 5 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Adenoma 4 | 167
Brain Ischemia 4 | 110
Byzanthine arch palate 4 | 194
Carcinoma, Hepatocellular 4 | 228
Duchenne muscular dystrophy 4 | 601
Endometrial cancer 4 | 311
Glaucoma 4 | 239
Hyperplasia 4 | 27
Liver carcinoma 4 | 240
Mood Disorders 4 | 184
Reperfusion Injury 4 | 86
acute quadriplegic myopathy 4 | 1,158
colon cancer 4 | 1,478
pituitary cancer 4 | 1,972

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Kinase 11 | 634
Enzyme 5 | 4,145
Non-IDG 4 | 12,091
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

Angiogenesis 24 | 24
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Metalloproteinase inhibitor 3 TIMP3 Tbio Enzyme -2.76157 592.3 503
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Vascular endothelial growth factor receptor 2 KDR Tclin Kinase -3.67555 4544.8 2373
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
Angiopoietin-1 receptor TEK Tclin Kinase -3.00257 906.7 1009
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Aryl hydrocarbon receptor nuclear translocator ARNT Tbio Transcription Factor -2.53687 261.2 474
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -4.00542 10573.5 798
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442