Development Level

Tbio 51 | 11,445
Tchem 30 | 1,598
Tclin 7 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
embryonic lethality prior to o... 3 | 239
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating choleste... 2 | 66
increased circulating glycerol... 2 | 9
increased hemoglobin content 2 | 45
increased startle reflex 2 | 112
abnormal blood vessel morpholo... 1 | 5
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatine... 1 | 5
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
long tibia 1 | 25
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small seminal vesicle 1 | 10
small spleen 1 | 19
small testis 1 | 58

Disease

ovarian cancer 72 | 8,520
Carcinoma 67 | 11,493
Cancer 64 | 2,499
osteosarcoma 60 | 7,950
psoriasis 44 | 6,694
glioblastoma 41 | 5,792
lung cancer 41 | 4,740
Breast cancer 39 | 3,578
medulloblastoma, large-cell 38 | 6,241
atypical teratoid / rhabdoid tumor 36 | 5,112
ependymoma 33 | 4,679
Kidney cancer 25 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Breast Neoplasms 24 | 445
Mammary Neoplasms 24 | 425
adult high grade glioma 23 | 3,801
diabetes mellitus 23 | 1,728
group 3 medulloblastoma 23 | 4,104
malignant mesothelioma 23 | 3,232
oligodendroglioma 23 | 2,850
Prostatic Neoplasms 22 | 495
primitive neuroectodermal tumor 22 | 3,035
subependymal giant cell astrocytoma 22 | 2,287
astrocytoma 20 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pancreatic cancer 19 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Multiple myeloma 18 | 1,332
Astrocytoma, Pilocytic 17 | 3,081
Schizophrenia 17 | 1,160
non-small cell lung cancer 17 | 2,890
pituitary cancer 17 | 1,972
acute quadriplegic myopathy 16 | 1,158
astrocytic glioma 16 | 2,597
group 4 medulloblastoma 16 | 1,855
Rheumatoid arthritis 15 | 1,191
breast carcinoma 15 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Intellectual disability 14 | 1,016
Obesity 14 | 678
Waldenstrons macroglobulinemia 14 | 765
invasive ductal carcinoma 14 | 2,951
lung adenocarcinoma 14 | 2,716
Carcinoma, Hepatocellular 13 | 228
Stomach Neoplasms 13 | 300
juvenile dermatomyositis 13 | 1,187
tuberculosis 13 | 2,010
Dull intelligence 12 | 645
Liver carcinoma 12 | 240
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Neoplasm Invasiveness 12 | 161
Pick disease 12 | 1,894
Poor school performance 12 | 645
Squamous cell carcinoma 12 | 129
ductal carcinoma in situ 12 | 1,745
Acquired scoliosis 11 | 281
Bipolar Disorder 11 | 666
Curvature of spine 11 | 282
Liver Cirrhosis, Experimental 11 | 769
Mammary Neoplasms, Experimental 11 | 154
Short stature 11 | 531
Vascular disease 11 | 319
colon cancer 11 | 1,478
Carcinoma, Squamous Cell 10 | 110
Cell Transformation, Neoplastic 10 | 97
Colonic Neoplasms 10 | 142
Endometriosis 10 | 540
Epilepsy 10 | 792
Heart disease 10 | 306
Hypertension 10 | 396
Hypertensive disease 10 | 292
Kidney disease 10 | 430
Neoplasm Metastasis 10 | 168
Orbital separation excessive 10 | 244
dermatomyositis 10 | 966
primary pancreatic ductal adenocarcinoma 10 | 1,109
spina bifida 10 | 1,074
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Bladder Neoplasm 9 | 112
Byzanthine arch palate 9 | 194
Cognitive delay 9 | 608
Crohn's disease 9 | 321
Endometrial cancer 9 | 311
Global developmental delay 9 | 608
Hypoplastic mandible condyle 9 | 275
Lung Neoplasms 9 | 232
Mandibular hypoplasia 9 | 275
Mental and motor retardation 9 | 608
Micrognathism 9 | 275
Muscle hypotonia 9 | 571
Parkinson's disease 9 | 392
Prostate cancer 9 | 175
Seizures 9 | 596
Strabismus 9 | 270
Urinary Bladder Neoplasms 9 | 114
medulloblastoma 9 | 720
ulcerative colitis 9 | 1,819

Tissue

Blood and immune system 88 | 16,909
Endocrine System 88 | 18,159
Digestive Tract 87 | 17,369
Female tissues 87 | 17,400
Liver and Pancreas 87 | 16,750
Male tissues 87 | 17,142
Respiratory system 87 | 16,393
Skin and soft tissues 87 | 17,230
Urinary Tract 87 | 16,678
Cardiovascular System 86 | 15,192
Nervous System 86 | 16,725

Target Family

Non-IDG 27 | 12,091
Transcription Factor 20 | 1,400
Enzyme 18 | 4,145
Epigenetic 10 | 242
Kinase 10 | 634
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

WikiPathways Pathway

Androgen receptor signaling pa... 89 | 89
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
BAG family molecular chaperone regulator 1 BAG1 Tbio Non-IDG -2.50252 335.1 394
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 Tbio Transcription Factor -1.98463 95.1 106
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Transforming growth factor beta-1-induced transcript 1 protein TGFB1I1 Tbio Non-IDG -1.82580 89.7 147
Zinc finger MIZ domain-containing protein 1 ZMIZ1 Tbio Transcription Factor -1.57174 37.9 126
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
EF-hand calcium-binding domain-containing protein 6 EFCAB6 Tdark Non-IDG -0.67693 4.17 19