Development Level

Tbio 8 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal heart morphology 2 | 162
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
enlarged heart 1 | 210
impaired righting response 1 | 26
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

Carcinoma 16 | 11,493
Cancer 12 | 2,499
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
lung carcinoma 11 | 2,843
Breast cancer 10 | 3,578
ependymoma 10 | 4,679
glioblastoma 10 | 5,792
psoriasis 10 | 6,694
Kidney cancer 9 | 2,613
invasive ductal carcinoma 9 | 2,951
lung cancer 9 | 4,740
Astrocytoma, Pilocytic 8 | 3,081
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
interstitial cystitis 8 | 2,312
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
ulcerative colitis 8 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
ductal carcinoma in situ 6 | 1,745
juvenile dermatomyositis 6 | 1,187
medulloblastoma, large-cell 6 | 6,241
primary Sjogren syndrome 6 | 735
Breast Neoplasms 5 | 445
Colonic Neoplasms 5 | 142
Duchenne muscular dystrophy 5 | 601
Heart disease 5 | 306
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 807
group 4 medulloblastoma 5 | 1,855
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis 5 | 2,010
Asthma 4 | 385
Atopic dermatitis 4 | 952
Kidney disease 4 | 430
Mammary Neoplasms 4 | 425
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
subependymal giant cell astrocytoma 4 | 2,287
Arthritis 3 | 290
Bipolar Disorder 3 | 666
Carcinoma, Pancreatic Ductal 3 | 20
Cataract 3 | 297
Cell Transformation, Neoplastic 3 | 97
Cerebrovascular disease 3 | 238
Colorectal Neoplasms 3 | 243
Heart failure 3 | 162
Hyperglycemia 3 | 137
Hypertension 3 | 396
Liver Cirrhosis 3 | 181
Multiple Sclerosis 3 | 540
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Neoplastic Cell Transformation 3 | 89
Obesity 3 | 678
Osteoporosis 3 | 363
Renal Cell Carcinoma 3 | 214
Type 2 diabetes mellitus 3 | 272
Uterine Cervical Neoplasm 3 | 25
Uterine Cervical Neoplasms 3 | 26
Vascular disease 3 | 319
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pediatric high grade glioma 3 | 1,064
periodontitis 3 | 293
pituitary cancer 3 | 1,972
sarcoidosis 3 | 370
Alzheimer's disease 2 | 658
Arthritis, Juvenile 2 | 126
Atherosclerosis 2 | 291
Collagen disease 2 | 27
Coronary artery disease 2 | 268
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Endometriosis 2 | 540
Failure to gain weight 2 | 365
Hypereosinophilic syndrome 2 | 71
Hypersensitivity reaction type II disease 2 | 253
Juvenile arthritis 2 | 126
Lung disease 2 | 142
Myocardial Ischemia 2 | 169
Pediatric failure to thrive 2 | 365
Strabismus 2 | 270
adrenocortical carcinoma 2 | 1,428
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Non-IDG 9 | 12,091
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,145
GPCR 1 | 408

WikiPathways Pathway

Amplification and Expansion of... 17 | 17
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tenascin TNC Tbio Non-IDG -2.34421 216.5 642
Periostin POSTN Tbio Non-IDG -2.84323 747.5 396
Endothelial PAS domain-containing protein 1 EPAS1 Tchem Non-IDG -2.29071 180.5 477
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
von Hippel-Lindau disease tumor suppressor VHL Tchem Enzyme -2.47495 292.9 508
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591
C-X-C chemokine receptor type 4 CXCR4 Tclin GPCR -3.41606 2525.3 1240
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Transcription factor 7 TCF7 Tbio Transcription Factor -1.74770 44.8 325