Development Level

Tbio 51 | 11,445
Tchem 32 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased total body fat amoun... 4 | 207
embryonic lethality prior to o... 4 | 239
cataract 3 | 92
decreased body weight 3 | 161
decreased lean body mass 3 | 135
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
abnormal QT variability 1 | 10
abnormal digit morphology 1 | 10
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased IgM level 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased urine magnesium leve... 1 | 3
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 76 | 11,493
ovarian cancer 52 | 8,520
psoriasis 52 | 6,694
medulloblastoma, large-cell 39 | 6,241
Autosomal recessive predisposition 38 | 1,442
lung cancer 37 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
osteosarcoma 33 | 7,950
atypical teratoid / rhabdoid tumor 30 | 5,112
glioblastoma 28 | 5,792
Epilepsy 27 | 792
Intellectual disability 26 | 1,016
Cognitive delay 25 | 608
Global developmental delay 25 | 608
Mental and motor retardation 25 | 608
invasive ductal carcinoma 25 | 2,951
Breast cancer 24 | 3,578
group 3 medulloblastoma 24 | 4,104
Cancer 23 | 2,499
Seizures 23 | 596
adult high grade glioma 23 | 3,801
ependymoma 23 | 4,679
non-small cell lung cancer 23 | 2,890
lung adenocarcinoma 22 | 2,716
ulcerative colitis 21 | 1,819
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Muscle hypotonia 20 | 571
Poor school performance 20 | 645
interstitial cystitis 18 | 2,312
primitive neuroectodermal tumor 18 | 3,035
ductal carcinoma in situ 17 | 1,745
Liver Cirrhosis, Experimental 16 | 769
Multiple myeloma 16 | 1,332
astrocytic glioma 16 | 2,597
colon cancer 16 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung carcinoma 16 | 2,843
malignant mesothelioma 16 | 3,232
oligodendroglioma 16 | 2,850
Astrocytoma, Pilocytic 15 | 3,081
Schizophrenia 15 | 1,160
adrenocortical carcinoma 15 | 1,428
pancreatic cancer 15 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pituitary cancer 14 | 1,972
Failure to gain weight 13 | 365
Hypoglycemia 13 | 152
Kidney cancer 13 | 2,613
Pediatric failure to thrive 13 | 365
diabetes mellitus 13 | 1,728
Alcoholic Intoxication, Chronic 12 | 289
Bipolar Disorder 12 | 666
Pick disease 12 | 1,894
tuberculosis 12 | 2,010
Dystonia 11 | 164
Obesity 11 | 678
breast carcinoma 11 | 1,638
Cerebellar Ataxia 10 | 304
Infantile onset 10 | 238
Metabolic acidosis 10 | 90
acute myeloid leukemia 10 | 783
cystic fibrosis 10 | 1,696
esophageal adenocarcinoma 10 | 737
nephrosclerosis 10 | 333
Hyperammonemia 9 | 30
acute quadriplegic myopathy 9 | 1,158
aldosterone-producing adenoma 9 | 665
nasopharyngeal carcinoma 9 | 1,058
Carcinoma, Hepatocellular 8 | 228
Hypertension 8 | 396
Liver carcinoma 8 | 240
Small head 8 | 374
active ulcerative colitis 8 | 764
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
dermatomyositis 8 | 966
group 4 medulloblastoma 8 | 1,855
subependymal giant cell astrocytoma 8 | 2,287
Acidosis, Lactic 7 | 97
Cerebral atrophy 7 | 178
Depressive disorder 7 | 409
Hepatomegaly 7 | 285
Highly variable clinical phenotype 7 | 150
Hyperreflexia 7 | 209
Lactic acidosis 7 | 51
Major Depressive Disorder 7 | 301
Mood Disorders 7 | 184
Phenotypic variability 7 | 150
Short stature 7 | 531
Unipolar Depression 7 | 250
Vomiting 7 | 116
Waldenstrons macroglobulinemia 7 | 765
active Crohn's disease 7 | 922
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
pancreatic carcinoma 7 | 562

Tissue

Digestive Tract 92 | 17,369
Liver and Pancreas 92 | 16,750
Endocrine System 91 | 18,159
Female tissues 91 | 17,400
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Blood and immune system 90 | 16,909
Nervous System 90 | 16,725
Male tissues 88 | 17,142
Respiratory system 87 | 16,393
Cardiovascular System 84 | 15,192

Target Family

Enzyme 86 | 4,145
Kinase 3 | 634
Non-IDG 3 | 12,091

WikiPathways Pathway

Amino Acid metabolism 92 | 92
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Arginase-2, mitochondrial ARG2 Tchem Enzyme -2.46702 275.2 245
Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 Tbio Enzyme -1.48800 26.8 73
ATP-citrate synthase ACLY Tchem Enzyme -2.82704 654.3 332
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0