Development Level

Tchem 36 | 1,890
Tbio 28 | 10,625
Tclin 14 | 602
Tdark 2 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal embryo size 4 | 112
embryonic lethality prior to t... 4 | 187
abnormal behavior 3 | 226
abnormal bone structure 2 | 131
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal limb bud morphology 2 | 15
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
cyanosis 2 | 6
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating bilirubi... 2 | 14
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
edema 2 | 11
hemorrhage 2 | 12
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
male infertility 2 | 62
respiratory system phenotype 2 | 2
thrombocytopenia 2 | 46
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 3
abnormal limb morphology 1 | 7
abnormal maxilla morphology 1 | 16
abnormal pericardium morpholog... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal sensory capabilities/... 1 | 3
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased circulating aspartat... 1 | 27
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating magnesiu... 1 | 11
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased prepulse inhibition 1 | 52
decreased total retina thickne... 1 | 20
enlarged heart 1 | 111
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased startle reflex 1 | 38
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
premature death 1 | 5
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3
small superior vagus ganglion 1 | 20

Disease

psoriasis 46 | 6,685
glioblastoma 44 | 5,572
ovarian cancer 44 | 8,484
osteosarcoma 41 | 7,933
medulloblastoma, large-cell 40 | 6,234
Cancer 36 | 2,346
atypical teratoid / rhabdoid tumor 32 | 4,369
pilocytic astrocytoma 32 | 3,086
lung cancer 31 | 4,466
Alzheimer's disease 30 | 644
oligodendroglioma 25 | 2,849
Toxic encephalopathy 24 | 131
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,289
subependymal giant cell astrocytoma 23 | 2,287
lung carcinoma 22 | 2,844
primitive neuroectodermal tumor 22 | 3,031
diabetes mellitus 21 | 1,663
Breast cancer 20 | 3,094
malignant mesothelioma 20 | 3,162
pediatric high grade glioma 20 | 2,712
Pick disease 19 | 1,893
ependymoma 19 | 2,514
Schizophrenia 18 | 501
invasive ductal carcinoma 18 | 2,950
Carcinoma 17 | 2,147
Parkinson's disease 17 | 364
adult high grade glioma 17 | 2,148
colon cancer 16 | 1,475
lung adenocarcinoma 16 | 2,713
medulloblastoma 16 | 1,524
pancreatic cancer 15 | 2,300
ulcerative colitis 15 | 2,087
Dementia 14 | 129
Neurodegenerative disease 14 | 383
astrocytic glioma 14 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
Rheumatoid Arthritis 13 | 1,160
Vascular disease 13 | 281
astrocytoma 13 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
Heart disease 12 | 279
non-small cell lung cancer 12 | 2,798
Amyloidosis 11 | 68
Brain Ischemia 11 | 87
Kidney disease 11 | 396
cutaneous lupus erythematosus 11 | 1,056
group 4 medulloblastoma 11 | 1,875
posterior fossa group A ependymoma 11 | 1,511
Brain disease 10 | 83
Nerve Degeneration 10 | 73
Obesity 10 | 616
interstitial cystitis 10 | 2,299
pituitary cancer 10 | 1,972
Cerebrovascular disease 9 | 231
Epilepsy 9 | 346
Hypertension 9 | 287
Prostatic Neoplasms 9 | 471
acute quadriplegic myopathy 9 | 1,157
cystic fibrosis 9 | 1,665
ductal carcinoma in situ 9 | 1,745
group 3 medulloblastoma 9 | 2,254
juvenile dermatomyositis 9 | 1,189
tuberculosis 9 | 1,557
Amyotrophic Lateral Sclerosis 8 | 431
Atopic dermatitis 8 | 944
Diabetes Mellitus, Experimental 8 | 106
Lung Neoplasms 8 | 171
atypical teratoid/rhabdoid tumor 8 | 1,095
esophageal adenocarcinoma 8 | 737
Diabetes Mellitus, Non-Insulin-Dependent 7 | 157
Heart failure 7 | 80
Liver disease 7 | 219
Mammary Neoplasms 7 | 410
Melanoma 7 | 261
Multiple Sclerosis 7 | 498
Multiple myeloma 7 | 1,327
Pancreatitis 7 | 97
Stomach Neoplasms 7 | 282
adrenocortical carcinoma 7 | 1,427
dermatomyositis 7 | 933
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
primary pancreatic ductal adenocarcinoma 7 | 1,271
Atherosclerosis 6 | 275
Bipolar Disorder 6 | 266
Cardiomyopathies 6 | 90
Hyperalgesia 6 | 71
Lung disease 6 | 132
Myocardial Reperfusion Injury 6 | 34
Necrosis 6 | 51
Status Epilepticus 6 | 85
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,614
nasopharyngeal carcinoma 6 | 1,056
non primary Sjogren syndrome sicca 6 | 840
non-small cell lung carcinoma 6 | 413
pancreatic carcinoma 6 | 567
periodontitis 6 | 269
posterior fossa group B ependymoma 6 | 1,530
progressive supranuclear palsy 6 | 674
sonic hedgehog group medulloblastoma 6 | 1,482

Tissue

Blood and immune system 80 | 17,995
Cardiovascular System 80 | 17,958
Digestive Tract 80 | 18,473
Endocrine System 80 | 18,512
Female tissues 80 | 18,647
Liver and Pancreas 80 | 18,136
Male tissues 80 | 17,969
Nervous System 80 | 18,561
Respiratory system 80 | 17,484
Skin and soft tissues 80 | 18,115
Urinary Tract 80 | 18,444

Target Family

Enzyme 28 | 4,146
Non-IDG 28 | 11,971
Ion Channel 13 | 341
Kinase 6 | 634
Transporter 3 | 473
Transcription Factor 2 | 1,400

WikiPathways Pathway

Alzheimers Disease 80 | 80
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Alpha-synuclein SNCA Tchem Non-IDG -3.59982 3997.3 1484
Cytochrome c CYCS Tbio Non-IDG -3.73952 4771.4 630
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -2.95943 932.4 290
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.02975 1184.8 589