Development Level

Tchem 36 | 1,885
Tbio 29 | 11,178
Tclin 16 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 5 | 220
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased circulating sodium l... 3 | 22
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
cyanosis 2 | 7
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic growth retardation 2 | 106
hemorrhage 2 | 23
increased bone mineral content 2 | 108
male infertility 2 | 123
pallor 2 | 34
respiratory system phenotype 2 | 2
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta vasculature 1 | 2
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
increased B cell number 1 | 9
increased basophil cell number 1 | 7
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
polycystic kidney 1 | 15
premature death 1 | 5
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
small epididymis 1 | 3
syndactyly 1 | 23
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 53 | 11,192
glioblastoma 46 | 5,635
psoriasis 46 | 6,514
ovarian cancer 44 | 8,297
medulloblastoma, large-cell 40 | 6,086
osteosarcoma 40 | 7,766
atypical teratoid / rhabdoid tumor 37 | 4,971
Cancer 36 | 2,388
Schizophrenia 34 | 1,136
Astrocytoma, Pilocytic 33 | 3,006
ependymoma 32 | 4,559
lung cancer 31 | 4,607
Alzheimer's disease 30 | 640
adult high grade glioma 29 | 3,701
Toxic encephalopathy 26 | 139
Breast cancer 25 | 3,469
oligodendroglioma 25 | 2,768
subependymal giant cell astrocytoma 24 | 2,230
diabetes mellitus 23 | 1,683
group 3 medulloblastoma 23 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,204
primitive neuroectodermal tumor 23 | 2,957
Kidney cancer 21 | 2,548
astrocytic glioma 20 | 2,530
lung carcinoma 20 | 2,755
Pick disease 19 | 1,856
malignant mesothelioma 19 | 3,135
Bipolar Disorder 18 | 646
Parkinson's disease 18 | 378
pancreatic cancer 18 | 2,322
invasive ductal carcinoma 17 | 2,867
Epilepsy 16 | 775
Autosomal recessive predisposition 15 | 1,407
Neurodegenerative disease 15 | 402
colon cancer 15 | 1,428
lung adenocarcinoma 15 | 2,627
Dementia 14 | 172
Depressive disorder 14 | 401
Heart disease 14 | 288
Hypertension 13 | 372
Rheumatoid arthritis 13 | 1,156
Vascular disease 13 | 294
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,902
non-small cell lung cancer 13 | 2,799
Amyloidosis 12 | 64
Cerebrovascular disease 12 | 223
Melanoma 12 | 689
group 4 medulloblastoma 12 | 1,806
tuberculosis 12 | 1,963
ulcerative colitis 12 | 1,765
Alzheimer Disease 11 | 80
Brain Ischemia 11 | 107
Mental Depression 11 | 325
Obesity 11 | 655
Seizures 11 | 584
Brain disease 10 | 95
Disease Models, Animal 10 | 148
Nerve Degeneration 10 | 118
cutaneous lupus erythematosus 10 | 1,016
interstitial cystitis 10 | 2,237
pituitary cancer 10 | 1,915
Amyotrophic lateral sclerosis 9 | 437
Intellectual disability 9 | 998
Kidney disease 9 | 411
Lung Neoplasms 9 | 217
Alcoholic Intoxication, Chronic 8 | 283
Atopic dermatitis 8 | 915
Diabetes Mellitus, Experimental 8 | 101
Endometrial cancer 8 | 301
Heart failure 8 | 157
Hypertensive disease 8 | 278
Major Depressive Disorder 8 | 293
Myocardial Infarction 8 | 142
Prostatic Neoplasms 8 | 472
Skin cancer 8 | 451
Splenomegaly 8 | 186
acute quadriplegic myopathy 8 | 1,133
cystic fibrosis 8 | 1,629
ductal carcinoma in situ 8 | 1,686
esophageal adenocarcinoma 8 | 696
juvenile dermatomyositis 8 | 1,147
pediatric high grade glioma 8 | 1,035
Atherosclerosis 7 | 276
Cognitive delay 7 | 596
Diabetes Mellitus, Non-Insulin-Dependent 7 | 140
Diabetes Mellitus, Type 2 7 | 136
Dull intelligence 7 | 634
Global developmental delay 7 | 596
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental and motor retardation 7 | 596
Mental deficiency 7 | 634
Multiple Sclerosis 7 | 527
Multiple myeloma 7 | 1,296
Poor school performance 7 | 634
adrenocortical carcinoma 7 | 1,385
hepatocellular carcinoma 7 | 536
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
primary pancreatic ductal adenocarcinoma 7 | 1,071

Tissue

Endocrine System 81 | 18,159
Blood and immune system 80 | 16,909
Digestive Tract 80 | 17,369
Skin and soft tissues 80 | 17,230
Female tissues 79 | 17,400
Liver and Pancreas 79 | 16,750
Male tissues 79 | 17,142
Nervous System 79 | 16,725
Respiratory system 78 | 16,393
Urinary Tract 78 | 16,678
Cardiovascular System 74 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 28 | 4,145
Ion Channel 13 | 344
Kinase 6 | 634
Transporter 3 | 473
Transcription Factor 2 | 1,400

WikiPathways Pathway

Alzheimers Disease 82 | 82
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 PLCB4 Tbio Enzyme -1.77110 57.7 19
Chondroitin sulfate glucuronyltransferase CHPF2 Tbio Enzyme -0.51521 3.67 74
Vacuole membrane protein 1 VMP1 Tbio Non-IDG -2.49755 302.1 137
Ryanodine receptor 3 RYR3 Tclin Ion Channel -2.15460 142.3 16
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230
Nitric oxide synthase, brain NOS1 Tchem Enzyme -3.27741 1885.8 661
Beta-secretase 1 BACE1 Tchem Enzyme -3.37358 2003.3 647
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Up-regulated during skeletal muscle growth protein 5 ATP5MD Tdark Non-IDG -1.16716 15.2 49
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800