Development Level

Tbio 19 | 11,445
Tchem 11 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 30 | 11,493
Cancer 22 | 2,499
ovarian cancer 22 | 8,520
Breast cancer 19 | 3,578
Kidney cancer 18 | 2,613
lung cancer 18 | 4,740
glioblastoma 16 | 5,792
osteosarcoma 16 | 7,950
psoriasis 15 | 6,694
medulloblastoma, large-cell 14 | 6,241
pancreatic cancer 14 | 2,398
atypical teratoid / rhabdoid tumor 13 | 5,112
lung carcinoma 12 | 2,843
ependymoma 11 | 4,679
Autosomal recessive predisposition 10 | 1,442
Schizophrenia 10 | 1,160
breast carcinoma 10 | 1,638
diabetes mellitus 10 | 1,728
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
non-small cell lung cancer 10 | 2,890
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
Astrocytoma, Pilocytic 7 | 3,081
Heart disease 7 | 306
Myopia 7 | 176
Stomach Neoplasms 7 | 300
juvenile dermatomyositis 7 | 1,187
subependymal giant cell astrocytoma 7 | 2,287
Anemia 6 | 365
Arthritis 6 | 290
Carcinoma, Hepatocellular 6 | 228
Carcinoma, Squamous Cell 6 | 110
Epilepsy 6 | 792
Failure to gain weight 6 | 365
Hyperglycemia 6 | 137
Intellectual disability 6 | 1,016
Liver carcinoma 6 | 240
Muscle hypotonia 6 | 571
Neoplasm Invasiveness 6 | 161
Pediatric failure to thrive 6 | 365
Prenatal onset 6 | 139
Rheumatoid arthritis 6 | 1,191
Seizures 6 | 596
Squamous cell carcinoma 6 | 129
Vascular disease 6 | 319
active ulcerative colitis 6 | 764
adult high grade glioma 6 | 3,801
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,312
primitive neuroectodermal tumor 6 | 3,035
ANONYCHIA 5 | 20
Alzheimer's disease 5 | 658
Aplasia Cutis Congenita 5 | 14
Atrophic scar 5 | 18
Big calvaria 5 | 147
Blepharoptosis 5 | 231
Congenital scar 5 | 13
Death in early childhood 5 | 82
Death in infancy 5 | 82
Defective enamel matrix 5 | 35
Dental Enamel Hypoplasia 5 | 43
Dysplasia of tooth enamel 5 | 35
Dystrophia unguium 5 | 53
Endometrial cancer 5 | 311
Epidermolysis bullosa 5 | 21
Fragile nails 5 | 16
Hypodontia 5 | 81
Hypoplastic mandible condyle 5 | 275
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Junctional split 5 | 6
Kidney disease 5 | 430
Lung Neoplasms 5 | 232
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Milium Cyst 5 | 16
Multiple myeloma 5 | 1,332
Nail dysplasia 5 | 52
Obesity 5 | 678
Oral mucosal blistering 5 | 10
Orbital separation excessive 5 | 244
Prostatic Neoplasms 5 | 495
Thin dental enamel 5 | 35
acute quadriplegic myopathy 5 | 1,158
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
tuberculosis 5 | 2,010

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 18 | 12,091
Kinase 10 | 634
Enzyme 5 | 4,145

WikiPathways Pathway

Alpha 6 Beta 4 signaling pathw... 33 | 33
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Laminin subunit gamma-1 LAMC1 Tbio Non-IDG -1.79184 56.7 318
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804
Integrin beta-4 ITGB4 Tbio Non-IDG -2.26591 177.4 704
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440