Development Level

Tbio 87 | 11,445
Tchem 34 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased vertical activity 7 | 208
preweaning lethality, incomple... 6 | 499
abnormal heart morphology 5 | 162
abnormal brain morphology 3 | 13
decreased circulating glucose ... 3 | 126
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
increased bone mineral density 3 | 72
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hydroencephaly 2 | 14
hyperactivity 2 | 148
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal ovary morphology 1 | 7
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent epididymis 1 | 3
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 93 | 11,493
psoriasis 84 | 6,694
Cancer 79 | 2,499
ovarian cancer 78 | 8,520
osteosarcoma 75 | 7,950
lung cancer 64 | 4,740
medulloblastoma, large-cell 61 | 6,241
glioblastoma 60 | 5,792
malignant mesothelioma 55 | 3,232
invasive ductal carcinoma 53 | 2,951
diabetes mellitus 52 | 1,728
Obesity 49 | 678
atypical teratoid / rhabdoid tumor 49 | 5,112
Breast cancer 45 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
pituitary cancer 42 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
ependymoma 40 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
ductal carcinoma in situ 38 | 1,745
lung carcinoma 38 | 2,843
non-small cell lung cancer 38 | 2,890
breast carcinoma 37 | 1,638
pancreatic cancer 37 | 2,398
group 3 medulloblastoma 35 | 4,104
adult high grade glioma 31 | 3,801
ulcerative colitis 31 | 1,819
Hyperglycemia 29 | 137
interstitial cystitis 29 | 2,312
Astrocytoma, Pilocytic 28 | 3,081
group 4 medulloblastoma 28 | 1,855
Polycystic ovary syndrome 27 | 360
Rheumatoid arthritis 27 | 1,191
acute quadriplegic myopathy 27 | 1,158
lung adenocarcinoma 27 | 2,716
primitive neuroectodermal tumor 27 | 3,035
tuberculosis 27 | 2,010
Prostatic Neoplasms 26 | 495
Schizophrenia 26 | 1,160
Atopic dermatitis 25 | 952
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Atherosclerosis 24 | 291
Autosomal recessive predisposition 24 | 1,442
Liver Cirrhosis, Experimental 24 | 769
Mammary Neoplasms 24 | 425
subependymal giant cell astrocytoma 24 | 2,287
Breast Neoplasms 23 | 445
oligodendroglioma 23 | 2,850
Hyperinsulinism 22 | 133
adrenocortical carcinoma 22 | 1,428
primary pancreatic ductal adenocarcinoma 22 | 1,109
Fatty liver disease 21 | 103
Hypertension 21 | 396
Insulin Resistance 21 | 72
Pick disease 21 | 1,894
astrocytic glioma 21 | 2,597
astrocytoma 21 | 1,146
colon cancer 21 | 1,478
juvenile dermatomyositis 21 | 1,187
Osteoporosis 20 | 363
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
fibroadenoma 20 | 559
Hypertensive disease 19 | 292
Lipid metabolism disorder 19 | 114
Liver disease 19 | 237
cystic fibrosis 19 | 1,696
Carcinoma, Hepatocellular 18 | 228
Coronary artery disease 18 | 268
Diabetes Mellitus, Non-Insulin-Dependent 18 | 145
Liver carcinoma 18 | 240
dermatomyositis 18 | 966
Kidney cancer 17 | 2,613
Lipodystrophy 17 | 40
Bipolar Disorder 16 | 666
Diabetes Mellitus, Experimental 16 | 108
Diabetes Mellitus, Type 2 16 | 142
Duchenne muscular dystrophy 16 | 601
gastric carcinoma 16 | 807
pediatric high grade glioma 16 | 1,064
Arthritis 15 | 290
Heart failure 15 | 162
Kidney disease 15 | 430
Short stature 15 | 531
Stomach Neoplasms 15 | 300
active Crohn's disease 15 | 922
active ulcerative colitis 15 | 764
aldosterone-producing adenoma 15 | 665
Alzheimer's disease 14 | 658
Asthma 14 | 385
Cerebrovascular disease 14 | 238
Depressive disorder 14 | 409
Heart disease 14 | 306
Mammary Neoplasms, Experimental 14 | 154
Endometriosis 13 | 540
Inflammatory bowel disease 13 | 151
Neoplasm Metastasis 13 | 168
non primary Sjogren syndrome sicca 13 | 891
Multiple myeloma 12 | 1,332
Myocardial Ischemia 12 | 169
cutaneous lupus erythematosus 12 | 1,057

Tissue

Endocrine System 129 | 18,159
Female tissues 129 | 17,400
Digestive Tract 128 | 17,369
Liver and Pancreas 127 | 16,750
Blood and immune system 126 | 16,909
Male tissues 124 | 17,142
Respiratory system 124 | 16,393
Skin and soft tissues 124 | 17,230
Urinary Tract 124 | 16,678
Nervous System 123 | 16,725
Cardiovascular System 121 | 15,192

Target Family

Non-IDG 59 | 12,091
Transcription Factor 41 | 1,400
Enzyme 14 | 4,145
Nuclear Receptor 10 | 48
Kinase 3 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Transporter 1 | 473

WikiPathways Pathway

Adipogenesis 130 | 130
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
Krueppel-like factor 6 KLF6 Tbio Transcription Factor -2.37304 253.6 161
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Testican-1 SPOCK1 Tbio Non-IDG -1.99465 104.6 92
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684