Development Level

Tbio 4 | 11,178
Tchem 4 | 1,885
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
decreased circulating glucose ... 2 | 126
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
embryonic growth retardation 1 | 106
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Carcinoma 7 | 11,192
ovarian cancer 6 | 8,297
Cancer 4 | 2,388
malignant mesothelioma 4 | 3,135
osteosarcoma 4 | 7,766
Ataxia telangiectasia 3 | 33
Breast cancer 3 | 3,469
Seckel syndrome 3 | 34
colon cancer 3 | 1,428
group 3 medulloblastoma 3 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,204
lung cancer 3 | 4,607
non-small cell lung cancer 3 | 2,799
psoriasis 3 | 6,514
Chronic Lymphocytic Leukemia 2 | 254
Nijmegen breakage syndrome 2 | 23
Waldenstrons macroglobulinemia 2 | 742
atypical teratoid / rhabdoid tumor 2 | 4,971
dermatomyositis 2 | 941
ependymoma 2 | 4,559
glioblastoma 2 | 5,635
invasive ductal carcinoma 2 | 2,867
tuberculosis and treatment for 6 months 2 | 399
11 pairs of ribs 1 | 7
Acquired flat foot 1 | 70
Agenesis of teeth 1 | 21
Alopecia 1 | 113
Amyotrophic lateral sclerosis type 3 1 | 17
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Aplastic Anemia 1 | 20
Auricular malformation 1 | 41
Bacillary angiomatosis 1 | 6
Blepharophimosis 1 | 69
Bloom syndrome 1 | 29
Breast Neoplasms 1 | 423
Cachexia 1 | 50
Chloracne 1 | 32
Cone-shaped epiphyses 1 | 24
Congenital myasthenic syndrome 6 1 | 17
Convex nasal ridge 1 | 36
Defective enamel matrix 1 | 34
Defective tooth enamel 1 | 29
Dengue disease 1 | 23
Dental Enamel Hypoplasia 1 | 42
Dental caries 1 | 157
Downward slant of palpebral fissure 1 | 158
Dysplasia of tooth enamel 1 | 34
Dystrophic tooth enamel 1 | 29
Enamel abnormalities 1 | 29
Epicondylitis 1 | 22
Facial asymmetry 1 | 31
Fanconi anemia 1 | 56
Flatfoot 1 | 71
Flexion contracture - elbow 1 | 30
Globe of eye large 1 | 19
Hip Dislocation, Congenital 1 | 46
Hyperactive behavior 1 | 90
Hyperplasia of nose 1 | 22
Hypertrophy of nose 1 | 22
Impaired cognition 1 | 95
Inadequate arch length for tooth size 1 | 45
Increased size of palpebral fissures 1 | 8
Isolated growth hormone deficiency type IA 1 | 1
Israeli tick typhus 1 | 2
Joint hyperflexibility 1 | 76
Large eyes 1 | 8
Large nose 1 | 22
Leukemia, Lymphocytic, Chronic, B-Cell 1 | 33
Malocclusion 1 | 57
Mammary Neoplasms 1 | 403
Meier-Gorlin syndrome 1 | 10
Mental impairment 1 | 95
Microcephalic osteodysplastic primordial dwarfism type II 1 | 13
Narrow face 1 | 54
Pachygyria 1 | 41
Penile hypospadias 1 | 102
Pneumoconiosis 1 | 14
Polyploidy 1 | 4
Postnatal growth retardation 1 | 56
Precociously senile appearance 1 | 18
Prion disease 1 | 16
Reduced number of teeth 1 | 21
Rotting teeth 1 | 69
Sandal gap 1 | 24
Simple ear 1 | 41
Single transverse palmar crease 1 | 29
Skull malformation 1 | 37
Sparse scalp hair 1 | 41
Spider Veins 1 | 17
Telangiectasis 1 | 35
Thin dental enamel 1 | 34
Thin face 1 | 54
Tooth Crowding 1 | 45
Tooth mass arch size discrepancy 1 | 45
Tooth size discrepancy 1 | 45
Typhoid fever 1 | 22
Urologic Neoplasms 1 | 8
Xeroderma pigmentosum 1 | 42
Xeroderma pigmentosum variant type 1 | 4

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 6 | 12,091
Kinase 2 | 634
Enzyme 1 | 4,145

WikiPathways Pathway

ATR Signaling 9 | 9
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA topoisomerase 2-binding protein 1 TOPBP1 Tbio Enzyme -2.04312 118.0 230
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.15330 141.0 919
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Checkpoint protein HUS1 HUS1 Tbio Non-IDG -1.87625 67.8 180
Cell cycle checkpoint protein RAD1 RAD1 Tchem Non-IDG -1.91713 78.3 245