Development Level

Tchem 20 | 1,598
Tbio 19 | 11,445
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal heart morphology 2 | 162
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased circulating insulin ... 1 | 76
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased circulating sodium l... 1 | 71
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

Cancer 34 | 2,499
ovarian cancer 30 | 8,520
Carcinoma 28 | 11,493
osteosarcoma 26 | 7,950
glioblastoma 25 | 5,792
lung cancer 25 | 4,740
psoriasis 25 | 6,694
atypical teratoid / rhabdoid tumor 23 | 5,112
group 3 medulloblastoma 23 | 4,104
medulloblastoma, large-cell 22 | 6,241
malignant mesothelioma 20 | 3,232
Breast cancer 18 | 3,578
primitive neuroectodermal tumor 18 | 3,035
ependymoma 16 | 4,679
Breast Neoplasms 14 | 445
adult high grade glioma 14 | 3,801
Ataxia telangiectasia 13 | 34
Mammary Neoplasms 13 | 425
non-small cell lung cancer 13 | 2,890
pancreatic cancer 13 | 2,398
Nijmegen breakage syndrome 12 | 24
adrenocortical carcinoma 12 | 1,428
oligodendroglioma 12 | 2,850
colon cancer 11 | 1,478
breast carcinoma 10 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Schizophrenia 9 | 1,160
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
Astrocytoma, Pilocytic 8 | 3,081
Intellectual disability 8 | 1,016
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
Prostatic Neoplasms 8 | 495
acute quadriplegic myopathy 8 | 1,158
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
Autosomal recessive predisposition 7 | 1,442
Dull intelligence 7 | 645
Endometriosis 7 | 540
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Pancreatic Neoplasm 7 | 85
Poor school performance 7 | 645
Short stature 7 | 531
Stomach Neoplasms 7 | 300
Carcinoma, Hepatocellular 6 | 228
Chromosome Breakage 6 | 36
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Small head 6 | 374
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
nasopharyngeal carcinoma 6 | 1,058
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,109
subependymal giant cell astrocytoma 6 | 2,287
Adenoid Cystic Carcinoma 5 | 99
Atopic dermatitis 5 | 952
Bladder Neoplasm 5 | 112
Carcinoma, Adenoid Cystic 5 | 99
Colonic Neoplasms 5 | 142
Epilepsy 5 | 792
Fanconi anemia 5 | 56
Pancreatic Neoplasms 5 | 85
Renal Cell Carcinoma 5 | 214
Thrombocytopenia 5 | 197
Urinary Bladder Neoplasms 5 | 114
Waldenstrons macroglobulinemia 5 | 765
Xeroderma pigmentosum 5 | 43
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
Amyotrophic lateral sclerosis 4 | 451
Anemia 4 | 365
Asthma 4 | 385
Bloom syndrome 4 | 29
Carcinoma, Renal Cell 4 | 124
Cell Transformation, Neoplastic 4 | 97
Decreased platelet count 4 | 111
Increased chromosomal breakage 4 | 27
Li-Fraumeni syndrome 4 | 13
Liver cancer 4 | 604
Lymphoma 4 | 81
Melanoma 4 | 711
Microcephaly 4 | 166
Neoplastic Cell Transformation 4 | 89
Polycystic ovary syndrome 4 | 360
Prostate cancer 4 | 175
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
gastric cancer 4 | 459
group 4 medulloblastoma 4 | 1,855
hepatocellular carcinoma 4 | 547
lung carcinoma 4 | 2,843

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Non-IDG 19 | 12,091
Kinase 10 | 634
Enzyme 5 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

ATM Signaling Pathway 40 | 40
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Death domain-containing protein CRADD CRADD Tbio Non-IDG -1.34614 23.0 400
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Fanconi anemia group D2 protein FANCD2 Tbio Non-IDG -2.59123 391.6 404
Tumor protein p73 TP73 Tbio Transcription Factor -1.92832 82.6 708
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
p53-induced death domain-containing protein 1 PIDD1 Tbio Non-IDG -2.00933 102.2 88
AP-3 complex subunit beta-2 AP3B2 Tbio Non-IDG -0.76737 5.95 100