Development Level

Tbio 24 | 11,445
Tchem 19 | 1,598
Tclin 2 | 613

IMPC Phenotype

abnormal behavior 3 | 298
embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
decreased circulating glucose ... 2 | 126
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal rib morphology 1 | 10
abnormal skin condition 1 | 6
abnormal spinal cord morpholog... 1 | 9
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
increased body length 1 | 32
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
shortened RR interval 1 | 17
vertebral fusion 1 | 23

Disease

Carcinoma 35 | 11,493
Cancer 29 | 2,499
ovarian cancer 29 | 8,520
lung cancer 28 | 4,740
osteosarcoma 25 | 7,950
glioblastoma 21 | 5,792
Breast cancer 20 | 3,578
ependymoma 18 | 4,679
medulloblastoma, large-cell 18 | 6,241
Kidney cancer 17 | 2,613
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 17 | 4,104
psoriasis 17 | 6,694
malignant mesothelioma 14 | 3,232
Ataxia telangiectasia 13 | 34
Intellectual disability 12 | 1,016
Nijmegen breakage syndrome 12 | 24
adult high grade glioma 11 | 3,801
non-small cell lung cancer 11 | 2,890
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
Small head 10 | 374
astrocytoma 10 | 1,146
colon cancer 10 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Autosomal recessive predisposition 9 | 1,442
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Short stature 9 | 531
invasive ductal carcinoma 9 | 2,951
tuberculosis 9 | 2,010
Pick disease 8 | 1,894
Schizophrenia 8 | 1,160
diabetes mellitus 8 | 1,728
subependymal giant cell astrocytoma 8 | 2,287
Astrocytoma, Pilocytic 7 | 3,081
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
breast carcinoma 7 | 1,638
lung adenocarcinoma 7 | 2,716
nasopharyngeal carcinoma 7 | 1,058
ulcerative colitis 7 | 1,819
Alzheimer's disease 6 | 658
Atopic dermatitis 6 | 952
Cognitive delay 6 | 608
Epilepsy 6 | 792
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Microcephaly 6 | 166
Renal Cell Carcinoma 6 | 214
Seckel syndrome 6 | 34
Stomach Neoplasms 6 | 300
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
Breast Neoplasms 5 | 445
Carcinoma, Squamous Cell 5 | 110
Endometriosis 5 | 540
Glaucoma 5 | 239
Mammary Neoplasms 5 | 425
Neurodegenerative disease 5 | 414
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Squamous cell carcinoma 5 | 129
Waldenstrons macroglobulinemia 5 | 765
non primary Sjogren syndrome sicca 5 | 891
pancreatic cancer 5 | 2,398
Attention deficit hyperactivity disorder 4 | 278
Bilateral fifth finger clinodactyly 4 | 110
Chronic Lymphocytic Leukemia 4 | 262
Concave bridge of nose 4 | 195
Curvature of little finger 4 | 110
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Endometrial cancer 4 | 311
Fanconi anemia 4 | 56
Fetal Growth Retardation 4 | 189
Hereditary Breast and Ovarian Cancer Syndrome 4 | 14
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Liver cancer 4 | 604
Multiple myeloma 4 | 1,332
Pancreatic Neoplasm 4 | 85
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
group 4 medulloblastoma 4 | 1,855
lung carcinoma 4 | 2,843
Bipolar Disorder 3 | 666
Vascular disease 3 | 319
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
spina bifida 3 | 1,074

Tissue

Blood and immune system 45 | 16,909
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Nervous System 45 | 16,725
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678

Target Family

Kinase 14 | 634
Non-IDG 14 | 12,091
Enzyme 10 | 4,145
Epigenetic 5 | 242
Transcription Factor 2 | 1,400

WikiPathways Pathway

ATM Signaling Network in Devel... 45 | 45
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Telomere-associated protein RIF1 RIF1 Tbio Non-IDG -0.03141 1.27 98
Protein phosphatase 1D PPM1D Tchem Enzyme -2.14384 181.8 218
Glucose-6-phosphate 1-dehydrogenase G6PD Tchem Enzyme -1.00936 10.8 469
E3 ubiquitin-protein ligase BRE1A RNF20 Tbio Enzyme -1.79588 62.2 224
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374