Development Level

Tbio 30 | 11,445
Tchem 30 | 1,598
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased body weight 4 | 161
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
decreased circulating LDL chol... 3 | 38
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
enlarged heart 3 | 210
enlarged spleen 3 | 41
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased mean platelet volume 3 | 45
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal spleen morphology 2 | 55
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating phosphat... 2 | 26
increased circulating total pr... 2 | 28
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
limb grasping 2 | 41
small seminal vesicle 2 | 10
small testis 2 | 58
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged thymus 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16
urinary bladder obstruction 1 | 4

Disease

Carcinoma 53 | 11,493
ovarian cancer 40 | 8,520
psoriasis 37 | 6,694
medulloblastoma, large-cell 34 | 6,241
Cancer 33 | 2,499
osteosarcoma 32 | 7,950
glioblastoma 29 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
diabetes mellitus 24 | 1,728
Obesity 23 | 678
Breast cancer 22 | 3,578
lung cancer 22 | 4,740
adult high grade glioma 21 | 3,801
ependymoma 20 | 4,679
Kidney cancer 17 | 2,613
invasive ductal carcinoma 15 | 2,951
primitive neuroectodermal tumor 15 | 3,035
Autosomal recessive predisposition 14 | 1,442
breast carcinoma 14 | 1,638
ductal carcinoma in situ 14 | 1,745
group 3 medulloblastoma 14 | 4,104
malignant mesothelioma 14 | 3,232
subependymal giant cell astrocytoma 14 | 2,287
Epilepsy 13 | 792
Schizophrenia 13 | 1,160
ulcerative colitis 13 | 1,819
Insulin Resistance 12 | 72
Seizures 12 | 596
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
oligodendroglioma 12 | 2,850
pancreatic cancer 12 | 2,398
Astrocytoma, Pilocytic 11 | 3,081
Breast Neoplasms 11 | 445
Fatty liver disease 11 | 103
Mammary Neoplasms 11 | 425
non-small cell lung cancer 11 | 2,890
Hyperglycemia 10 | 137
Polycystic ovary syndrome 10 | 360
astrocytic glioma 10 | 2,597
colon cancer 10 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pituitary cancer 10 | 1,972
Carcinoma, Hepatocellular 9 | 228
Diabetes Mellitus, Experimental 9 | 108
Lipid metabolism disorder 9 | 114
Liver carcinoma 9 | 240
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
tuberculosis 9 | 2,010
Cardiomegaly 8 | 116
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Hyperinsulinism 8 | 133
Hypertension 8 | 396
Intellectual disability 8 | 1,016
Pick disease 8 | 1,894
Prostatic Neoplasms 8 | 495
Renal Cell Carcinoma 8 | 214
dermatomyositis 8 | 966
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
lung adenocarcinoma 8 | 2,716
Bipolar Disorder 7 | 666
Diabetes Mellitus, Type 2 7 | 142
Endometrial cancer 7 | 311
Gynecomastia 7 | 64
Hypertensive disease 7 | 292
Lipodystrophy 7 | 40
Liver Cirrhosis, Experimental 7 | 769
Parkinson's disease 7 | 392
adrenocortical carcinoma 7 | 1,428
astrocytoma 7 | 1,146
primary Sjogren syndrome 7 | 735
Alzheimer's disease 6 | 658
Atopic dermatitis 6 | 952
Carcinoma, Squamous Cell 6 | 110
Cognitive delay 6 | 608
Endometriosis 6 | 540
Global developmental delay 6 | 608
Hypoglycemia 6 | 152
Hypothyroidism 6 | 122
Insulin resistant diabetes 6 | 13
Kidney Failure, Chronic 6 | 46
Kidney disease 6 | 430
Liver cancer 6 | 604
Lung Neoplasms 6 | 232
Mental and motor retardation 6 | 608
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
Waldenstrons macroglobulinemia 6 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
lung carcinoma 6 | 2,843
Hepatomegaly 5 | 285
Vascular disease 5 | 319
acute quadriplegic myopathy 5 | 1,158
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Endocrine System 68 | 18,159
Female tissues 67 | 17,400
Digestive Tract 66 | 17,369
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678
Blood and immune system 65 | 16,909
Cardiovascular System 65 | 15,192
Nervous System 64 | 16,725
Respiratory system 64 | 16,393

Target Family

Kinase 25 | 634
Non-IDG 18 | 12,091
Enzyme 17 | 4,145
Transcription Factor 3 | 1,400
GPCR 2 | 408
Transporter 2 | 473
Nuclear Receptor 1 | 48

WikiPathways Pathway

AMP-activated Protein Kinase (... 68 | 68
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin, isoform 2 INS-IGF2 Tbio Non-IDG -0.94621 7.72 72
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257
Myocyte-specific enhancer factor 2B BORCS8-MEF2B Tbio Transcription Factor -1.39011 20.0 113
Hormone-sensitive lipase LIPE Tchem Enzyme -2.75527 464.8 340
Acetyl-CoA carboxylase 2 ACACB Tchem Enzyme -2.25387 171.9 125
Alpha-1B adrenergic receptor ADRA1B Tclin GPCR -2.30594 201.5 364
Alpha-1A adrenergic receptor ADRA1A Tclin GPCR -2.18682 155.5 236
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Elongation factor 2 EEF2 Tchem Non-IDG -2.95619 938.4 363
Carnitine O-palmitoyltransferase 1, muscle isoform CPT1B Tchem Enzyme -2.33657 211.9 299