Development Level

Tchem 38 | 1,598
Tbio 20 | 11,445
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
increased circulating alkaline... 3 | 122
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged lymph nodes 2 | 37
increased circulating aspartat... 2 | 15
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal skin condition 1 | 6
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged kidney 1 | 14
impaired righting response 1 | 26
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
small adrenal glands 1 | 16
small spleen 1 | 19

Disease

Cancer 55 | 2,499
Carcinoma 53 | 11,493
ovarian cancer 46 | 8,520
glioblastoma 38 | 5,792
osteosarcoma 35 | 7,950
psoriasis 33 | 6,694
lung cancer 32 | 4,740
diabetes mellitus 30 | 1,728
atypical teratoid / rhabdoid tumor 29 | 5,112
ependymoma 28 | 4,679
Vascular disease 24 | 319
medulloblastoma, large-cell 24 | 6,241
adult high grade glioma 22 | 3,801
Breast cancer 21 | 3,578
malignant mesothelioma 21 | 3,232
Arthritis 20 | 290
Astrocytoma, Pilocytic 20 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
lung carcinoma 19 | 2,843
Hypertension 18 | 396
Schizophrenia 18 | 1,160
group 3 medulloblastoma 18 | 4,104
invasive ductal carcinoma 18 | 2,951
Brain Ischemia 17 | 110
Breast Neoplasms 17 | 445
Heart disease 17 | 306
Kidney cancer 17 | 2,613
Kidney disease 17 | 430
Mammary Neoplasms 17 | 425
Obesity 17 | 678
Prostatic Neoplasms 17 | 495
subependymal giant cell astrocytoma 17 | 2,287
Autosomal recessive predisposition 16 | 1,442
Liver Cirrhosis, Experimental 16 | 769
Rheumatoid arthritis 16 | 1,191
group 4 medulloblastoma 16 | 1,855
lung adenocarcinoma 16 | 2,716
tuberculosis 16 | 2,010
Alzheimer's disease 15 | 658
Cell Transformation, Neoplastic 15 | 97
Hypertensive disease 15 | 292
Multiple myeloma 15 | 1,332
Neoplastic Cell Transformation 15 | 89
oligodendroglioma 15 | 2,850
Asthma 14 | 385
Hyperglycemia 14 | 137
Lung disease 14 | 142
Stomach Neoplasms 14 | 300
pancreatic cancer 14 | 2,398
astrocytic glioma 13 | 2,597
astrocytoma 13 | 1,146
breast carcinoma 13 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
non-small cell lung cancer 13 | 2,890
pituitary cancer 13 | 1,972
Atherosclerosis 12 | 291
Diabetes Mellitus, Experimental 12 | 108
Diabetes Mellitus, Non-Insulin-Dependent 12 | 145
Neoplasm Invasiveness 12 | 161
Neoplasm Metastasis 12 | 168
Reperfusion Injury 12 | 86
Short stature 12 | 531
ductal carcinoma in situ 12 | 1,745
primitive neuroectodermal tumor 12 | 3,035
Diabetes Mellitus, Type 2 11 | 142
Disease Models, Animal 11 | 155
Inflammatory bowel disease 11 | 151
Pick disease 11 | 1,894
Waldenstrons macroglobulinemia 11 | 765
acute quadriplegic myopathy 11 | 1,158
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Bipolar Disorder 10 | 666
Cardiomegaly 10 | 116
Liver disease 10 | 237
Lung Neoplasms 10 | 232
cystic fibrosis 10 | 1,696
dermatomyositis 10 | 966
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
primary pancreatic ductal adenocarcinoma 10 | 1,109
Carcinoma, Hepatocellular 9 | 228
Cholestasis, Extrahepatic 9 | 25
Colonic Neoplasms 9 | 142
Hyperalgesia 9 | 83
Inflammation 9 | 120
Liver carcinoma 9 | 240
Pneumonia 9 | 174
Toxic encephalopathy 9 | 141
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
pediatric high grade glioma 9 | 1,064
ulcerative colitis 9 | 1,819
Amyotrophic lateral sclerosis 8 | 451
Depressive disorder 8 | 409
Eye disease 8 | 62
Hypersensitivity reaction type II disease 8 | 253
Mental Depression 8 | 333
Multiple Sclerosis 8 | 540
Parkinson's disease 8 | 392
juvenile dermatomyositis 8 | 1,187

Tissue

Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Respiratory system 66 | 16,393
Urinary Tract 66 | 16,678
Cardiovascular System 65 | 15,192
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Skin and soft tissues 65 | 17,230
Nervous System 64 | 16,725

Target Family

Kinase 20 | 634
Enzyme 17 | 4,145
Non-IDG 15 | 12,091
Transcription Factor 14 | 1,400

WikiPathways Pathway

AGE/RAGE pathway 66 | 66
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380