Development Level

Tbio 314 | 11,651
Tdark 69 | 6,593
Tchem 5 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 22 | 499
abnormal behavior 13 | 298
decreased bone mineral content 11 | 151
decreased bone mineral density 11 | 126
male infertility 11 | 123
abnormal bone structure 10 | 187
decreased body weight 10 | 161
embryonic lethality prior to t... 9 | 278
abnormal embryo size 7 | 220
enlarged heart 7 | 210
abnormal heart morphology 6 | 162
decreased body length 6 | 101
decreased lean body mass 6 | 135
decreased startle reflex 6 | 75
female infertility 6 | 60
increased mean corpuscular vol... 6 | 92
increased total body fat amoun... 6 | 134
short tibia 6 | 97
decreased circulating chloride... 5 | 30
decreased vertical activity 5 | 208
hypoactivity 5 | 132
increased lean body mass 5 | 172
increased or absent threshold ... 5 | 101
decreased circulating alkaline... 4 | 46
decreased circulating triglyce... 4 | 79
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
decreased mean corpuscular hem... 4 | 50
decreased prepulse inhibition 4 | 82
embryonic lethality prior to o... 4 | 239
enlarged spleen 4 | 41
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased heart weight 4 | 62
increased hematocrit 4 | 46
increased mean platelet volume 4 | 45
abnormal bone mineralization 3 | 38
abnormal gait 3 | 69
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
decreased basophil cell number 3 | 16
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
decreased circulating fructosa... 3 | 30
decreased circulating glucose ... 3 | 126
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased neutrophil cell numb... 3 | 42
decreased respiratory quotient 3 | 16
dilated heart left ventricle 3 | 11
embryonic growth retardation 3 | 106
hyperactivity 3 | 148
increased circulating chloride... 3 | 41
increased fasted circulating g... 3 | 76
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal retinal blood vessel ... 2 | 26
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
abnormal vocalization 2 | 21
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased food intake 2 | 13
decreased heart left ventricle... 2 | 28
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased eosinophil cell numb... 2 | 11
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small thymus 2 | 16
tremors 2 | 39
trunk curl 2 | 16

Disease

Carcinoma 267 | 11,493
ovarian cancer 246 | 8,520
osteosarcoma 190 | 7,950
medulloblastoma, large-cell 160 | 6,241
glioblastoma 135 | 5,792
atypical teratoid / rhabdoid tumor 132 | 5,112
psoriasis 125 | 6,694
lung cancer 95 | 4,740
adult high grade glioma 93 | 3,801
ependymoma 92 | 4,679
Breast cancer 86 | 3,578
group 3 medulloblastoma 83 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,291
primitive neuroectodermal tumor 72 | 3,035
malignant mesothelioma 68 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 66 | 2,989
Astrocytoma, Pilocytic 65 | 3,081
Kidney cancer 61 | 2,613
astrocytic glioma 60 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,955
subependymal giant cell astrocytoma 59 | 2,287
oligodendroglioma 57 | 2,850
Cancer 50 | 2,499
group 4 medulloblastoma 48 | 1,855
non-small cell lung cancer 48 | 2,890
pancreatic cancer 48 | 2,398
Pick disease 47 | 1,894
invasive ductal carcinoma 47 | 2,951
Multiple myeloma 44 | 1,332
juvenile dermatomyositis 43 | 1,187
lung carcinoma 39 | 2,843
spina bifida 39 | 1,074
lung adenocarcinoma 38 | 2,716
tuberculosis 37 | 2,010
Rheumatoid arthritis 36 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
acute quadriplegic myopathy 34 | 1,158
breast carcinoma 34 | 1,638
adrenocortical carcinoma 31 | 1,428
pituitary cancer 29 | 1,972
ulcerative colitis 29 | 1,819
Intellectual disability 27 | 1,016
interstitial cystitis 26 | 2,312
tuberculosis and treatment for 6 months 26 | 409
medulloblastoma 24 | 720
dermatomyositis 23 | 966
cystic fibrosis 22 | 1,696
primary pancreatic ductal adenocarcinoma 22 | 1,109
active Crohn's disease 20 | 922
acute myeloid leukemia 20 | 783
diabetes mellitus 20 | 1,728
non primary Sjogren syndrome sicca 20 | 891
Autosomal recessive predisposition 19 | 1,442
ductal carcinoma in situ 19 | 1,745
Atopic dermatitis 18 | 952
astrocytoma 18 | 1,146
hepatocellular carcinoma 18 | 547
Waldenstrons macroglobulinemia 17 | 765
cutaneous lupus erythematosus 17 | 1,057
Liver cancer 16 | 604
colon cancer 16 | 1,478
esophageal adenocarcinoma 16 | 737
pediatric high grade glioma 16 | 1,064
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
primary Sjogren syndrome 15 | 735
Parkinson's disease 14 | 392
gastric carcinoma 14 | 807
progressive supranuclear palsy 14 | 676
Multiple Sclerosis 12 | 540
active ulcerative colitis 12 | 764
sonic hedgehog group medulloblastoma 12 | 467
Amyotrophic lateral sclerosis 11 | 451
Neurodegenerative disease 11 | 414
Short stature 11 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
nasopharyngeal carcinoma 11 | 1,058
Duchenne muscular dystrophy 10 | 601
aldosterone-producing adenoma 10 | 665
Acquired scoliosis 9 | 281
Alzheimer's disease 9 | 658
Curvature of spine 9 | 282
Endometriosis 9 | 540
Gaucher disease type 1 9 | 180
Muscle hypotonia 9 | 571
Schizophrenia 9 | 1,160
pancreatic carcinoma 9 | 562
Attention deficit hyperactivity disorder 8 | 278
Cognitive delay 8 | 608
Congenital hypoplasia of penis 8 | 176
Global developmental delay 8 | 608
Kidney disease 8 | 430
Mental and motor retardation 8 | 608
Obesity 8 | 678
hereditary spastic paraplegia 8 | 318
posterior fossa group A ependymoma 8 | 468
gastric cancer 7 | 459

Tissue

Endocrine System 387 | 18,159
Female tissues 379 | 17,400
Male tissues 378 | 17,142
Digestive Tract 377 | 17,369
Skin and soft tissues 377 | 17,230
Nervous System 374 | 16,725
Respiratory system 374 | 16,393
Urinary Tract 374 | 16,678
Liver and Pancreas 373 | 16,750
Blood and immune system 371 | 16,909
Cardiovascular System 368 | 15,192

Target Family

Enzyme 190 | 4,145
Non-IDG 186 | 12,091
Epigenetic 9 | 242
Transcription Factor 5 | 1,400

UniProt Pathway

Protein modification; protein ... 390 | 390
Protein modification; protein ... 149 | 149
Glycolipid biosynthesis; glyco... 22 | 22
Protein modification; protein ... 17 | 17
Lipid metabolism; fatty acid b... 15 | 15
Lipid metabolism; sphingolipid... 15 | 15
Lipid metabolism; fatty acid b... 13 | 13
Cofactor biosynthesis; ubiquin... 11 | 11
Glycan metabolism; heparan sul... 11 | 11
Carbohydrate biosynthesis; glu... 10 | 10
Purine metabolism; 3',5'-cycli... 9 | 9
Cofactor metabolism; retinol m... 8 | 8
Lipid metabolism; phospholipid... 7 | 7
One-carbon metabolism; tetrahy... 7 | 7
Protein modification; peptidyl... 7 | 7
Lipid metabolism; fatty acid m... 6 | 6
Lipid metabolism; polyunsatura... 6 | 6
Phospholipid metabolism; CDP-d... 6 | 6
Sulfur metabolism; glutathione... 6 | 6
tRNA modification; wybutosine-... 6 | 6
Carbohydrate metabolism; hexos... 5 | 5
Cofactor biosynthesis; molybdo... 5 | 5
Fermentation; pyruvate ferment... 5 | 5
Glycan biosynthesis; glycogen ... 5 | 5
Glycan metabolism; heparin bio... 5 | 5
Glycerolipid metabolism; triac... 5 | 5
Lipid metabolism; hydroperoxy ... 5 | 5
Lipid metabolism; mitochondria... 5 | 5
Steroid biosynthesis; estrogen... 5 | 5
Alcohol metabolism; ethanol de... 4 | 4
Amino-sugar metabolism; N-acet... 4 | 4
Carbohydrate degradation; glyc... 4 | 4
Cofactor biosynthesis; coenzym... 4 | 4
Glycan metabolism; chondroitin... 4 | 4
Glycerolipid metabolism; triac... 4 | 4
Lipid metabolism; prostaglandi... 4 | 4
Lipid metabolism; steroid bios... 4 | 4
Phospholipid metabolism; CDP-d... 4 | 4
Phospholipid metabolism; phosp... 4 | 4
Polyol metabolism; glycerol de... 4 | 4
Protein modification; protein ... 4 | 4
Steroid biosynthesis; choleste... 4 | 4
tRNA modification; 5-methoxyca... 4 | 4
Amine and polyamine biosynthes... 3 | 3
Amino-acid biosynthesis; L-pro... 3 | 3
Amino-acid biosynthesis; S-ade... 3 | 3
Amino-acid degradation; L-tryp... 3 | 3
Amino-acid degradation; L-vali... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate metabolism; galac... 3 | 3
Carbohydrate metabolism; trica... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Genetic information processing... 3 | 3
Glycan biosynthesis; glycogen ... 3 | 3
Glycan biosynthesis; hyalurona... 3 | 3
Hormone biosynthesis; thyroid ... 3 | 3
Lipid metabolism; bile acid bi... 3 | 3
Metabolic intermediate biosynt... 3 | 3
Phospholipid metabolism; CDP-d... 3 | 3
Phospholipid metabolism; phosp... 3 | 3
Polyol metabolism; myo-inosito... 3 | 3
Protein modification; carbohyd... 3 | 3
Purine metabolism; 3',5'-cycli... 3 | 3
Purine metabolism; IMP biosynt... 3 | 3
Pyrimidine metabolism; CTP bio... 3 | 3
Pyrimidine metabolism; UMP bio... 3 | 3
Signal transduction; phosphati... 3 | 3
Amino-acid biosynthesis; L-cys... 2 | 2
Amino-acid biosynthesis; beta-... 2 | 2
Amino-acid degradation; L-alan... 2 | 2
Amino-acid degradation; L-leuc... 2 | 2
Aminoacyl-tRNA biosynthesis; s... 2 | 2
Aromatic compound metabolism; ... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate metabolism; trica... 2 | 2
Cofactor biosynthesis; adenosy... 2 | 2
Cofactor biosynthesis; iron-su... 2 | 2
Cofactor degradation; phylloqu... 2 | 2
Glycan metabolism; N-glycan me... 2 | 2
Isoprenoid biosynthesis; dimet... 2 | 2
Isoprenoid biosynthesis; farne... 2 | 2
Isoprenoid biosynthesis; geran... 2 | 2
Ketone metabolism; succinyl-Co... 2 | 2
Lipid metabolism; glycerolipid... 2 | 2
Nitrogen metabolism; urea cycl... 2 | 2
Nucleotide-sugar biosynthesis;... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Pigment biosynthesis; melanin ... 2 | 2
Porphyrin-containing compound ... 2 | 2
Purine metabolism; XMP biosynt... 2 | 2
Pyrimidine metabolism; dTTP bi... 2 | 2
Sulfur metabolism; glutathione... 2 | 2
Sulfur metabolism; sulfate ass... 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
Ankyrin repeat and SOCS box protein 10 ASB10 Tbio Non-IDG -0.85286 7.76 117
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
E3 ubiquitin-protein ligase DZIP3 DZIP3 Tbio Enzyme -0.24304 1.68 116
Ras-related protein Rab-40A RAB40A Tdark Non-IDG -0.72564 4.56 104
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171