Development Level

Tbio 294 | 10,625
Tdark 75 | 7,003
Tchem 10 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 17 | 633
preweaning lethality, incomple... 15 | 260
decreased lean body mass 14 | 195
abnormal behavior 13 | 226
decreased grip strength 11 | 123
decreased bone mineral content 10 | 157
decreased bone mineral density 9 | 126
decreased heart weight 8 | 44
increased or absent threshold ... 8 | 128
decreased body weight 7 | 174
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
abnormal bone mineralization 5 | 55
abnormal embryo size 5 | 112
decreased circulating triglyce... 5 | 83
decreased startle reflex 5 | 48
embryonic lethality prior to t... 5 | 187
hypoactivity 5 | 89
male infertility 5 | 62
abnormal retina morphology 4 | 100
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
hyperactivity 4 | 108
short tibia 4 | 82
decreased circulating alanine ... 3 | 53
decreased circulating fructosa... 3 | 31
decreased hemoglobin content 3 | 53
decreased prepulse inhibition 3 | 52
decreased respiratory quotient 3 | 12
decreased rib number 3 | 59
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
enlarged heart 3 | 111
increased grip strength 3 | 83
increased lean body mass 3 | 107
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal retinal blood vessel ... 2 | 18
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
abnormal vocalization 2 | 21
decreased basophil cell number 2 | 11
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating amylase ... 2 | 24
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased food intake 2 | 6
decreased heart rate 2 | 10
decreased mean corpuscular hem... 2 | 34
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
female infertility 2 | 34
improved glucose tolerance 2 | 56
increased NK cell number 2 | 19
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased circulating triglyce... 2 | 24
increased effector memory CD4-... 2 | 15
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 93
increased monocyte cell number 2 | 27
increased total body fat amoun... 2 | 57
narrow eye opening 2 | 15
small adrenal glands 2 | 15
small liver 2 | 8
small thymus 2 | 11
straub tail 2 | 26
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
corneal opacity 1 | 25
decreased effector memory CD8-... 1 | 24
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 239 | 8,484
osteosarcoma 187 | 7,933
medulloblastoma, large-cell 158 | 6,234
glioblastoma 131 | 5,572
psoriasis 124 | 6,685
atypical teratoid / rhabdoid tumor 118 | 4,369
lung cancer 87 | 4,466
Breast cancer 75 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 73 | 3,289
primitive neuroectodermal tumor 70 | 3,031
malignant mesothelioma 66 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 65 | 2,988
pilocytic astrocytoma 65 | 3,086
ependymoma 58 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,956
oligodendroglioma 57 | 2,849
subependymal giant cell astrocytoma 57 | 2,287
adult high grade glioma 56 | 2,148
astrocytic glioma 55 | 2,241
Carcinoma 52 | 2,147
pediatric high grade glioma 51 | 2,712
group 3 medulloblastoma 48 | 2,254
non-small cell lung cancer 47 | 2,798
Pick disease 46 | 1,893
invasive ductal carcinoma 46 | 2,950
Cancer 44 | 2,346
Multiple myeloma 44 | 1,327
group 4 medulloblastoma 44 | 1,875
juvenile dermatomyositis 43 | 1,189
medulloblastoma 42 | 1,524
pancreatic cancer 42 | 2,300
lung adenocarcinoma 39 | 2,713
lung carcinoma 38 | 2,844
spina bifida 37 | 1,064
Rheumatoid Arthritis 36 | 1,160
tuberculosis and treatment for 6 months 35 | 686
ulcerative colitis 35 | 2,087
acute quadriplegic myopathy 34 | 1,157
breast carcinoma 32 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,795
adrenocortical carcinoma 31 | 1,427
sonic hedgehog group medulloblastoma 30 | 1,482
pituitary cancer 28 | 1,972
interstitial cystitis 26 | 2,299
primary pancreatic ductal adenocarcinoma 25 | 1,271
Intellectual disability 23 | 573
astrocytoma 23 | 1,493
dermatomyositis 23 | 933
posterior fossa group B ependymoma 23 | 1,530
cystic fibrosis 22 | 1,665
posterior fossa group A ependymoma 22 | 1,511
tuberculosis 21 | 1,557
acute myeloid leukemia 20 | 780
active Crohn's disease 19 | 918
atypical teratoid/rhabdoid tumor 19 | 1,095
diabetes mellitus 19 | 1,663
ductal carcinoma in situ 19 | 1,745
non primary Sjogren syndrome sicca 19 | 840
Atopic dermatitis 18 | 944
Waldenstrons macroglobulinemia 17 | 765
cutaneous lupus erythematosus 17 | 1,056
hepatocellular carcinoma 17 | 532
colon cancer 16 | 1,475
esophageal adenocarcinoma 16 | 737
primary Sjogren syndrome 15 | 789
gastric carcinoma 14 | 832
progressive supranuclear palsy 14 | 674
Parkinson's disease 13 | 364
Amyotrophic Lateral Sclerosis 11 | 431
IGA Glomerulonephritis 11 | 454
Neurodegenerative disease 11 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
Duchenne muscular dystrophy 10 | 602
Multiple Sclerosis 10 | 498
aldosterone-producing adenoma 10 | 664
nasopharyngeal carcinoma 10 | 1,056
Alzheimer's disease 9 | 644
Gaucher disease type 1 9 | 171
pancreatic carcinoma 9 | 567
Autistic Disorder 8 | 320
Endometriosis 8 | 535
hereditary spastic paraplegia 8 | 313
tuberculosis and treatment for 3 months 8 | 327
Acquired metabolic disease 7 | 267
Kidney disease 7 | 396
Mammary Neoplasms 7 | 410
Prostatic Neoplasms 7 | 471
gastric cancer 7 | 430
sarcoidosis 7 | 358
Angelman syndrome 6 | 38
Cardiovascular system disease 6 | 194
Hypertension 6 | 287
Liddle syndrome 6 | 14
glioblastoma multiforme 6 | 347
inflammatory breast cancer 6 | 404
interstitial lung disease 6 | 291
mucosa-associated lymphoid tissue lymphoma 6 | 480
Down syndrome 5 | 548
Obesity 5 | 616
non diabetic and post-ischemic heart failure 5 | 200

Tissue

Nervous System 378 | 18,561
Digestive Tract 377 | 18,473
Female tissues 377 | 18,647
Liver and Pancreas 376 | 18,136
Urinary Tract 376 | 18,444
Blood and immune system 375 | 17,995
Cardiovascular System 375 | 17,958
Skin and soft tissues 375 | 18,115
Endocrine System 374 | 18,512
Male tissues 374 | 17,969
Respiratory system 370 | 17,484

Target Family

Enzyme 190 | 4,146
Non-IDG 178 | 11,971
Epigenetic 8 | 242
Transcription Factor 5 | 1,400

UniProt Pathway

Protein modification; protein ... 381 | 381
Protein modification; protein ... 144 | 144
Glycolipid biosynthesis; glyco... 22 | 22
Protein modification; protein ... 17 | 17
Lipid metabolism; fatty acid b... 15 | 15
Lipid metabolism; sphingolipid... 15 | 15
Lipid metabolism; fatty acid b... 13 | 13
Cofactor biosynthesis; ubiquin... 11 | 11
Glycan metabolism; heparan sul... 11 | 11
Carbohydrate biosynthesis; glu... 10 | 10
Purine metabolism; 3',5'-cycli... 9 | 9
Cofactor metabolism; retinol m... 8 | 8
Lipid metabolism; phospholipid... 7 | 7
One-carbon metabolism; tetrahy... 7 | 7
Protein modification; peptidyl... 7 | 7
Lipid metabolism; fatty acid m... 6 | 6
Lipid metabolism; polyunsatura... 6 | 6
Phospholipid metabolism; CDP-d... 6 | 6
Sulfur metabolism; glutathione... 6 | 6
tRNA modification; wybutosine-... 6 | 6
Carbohydrate metabolism; hexos... 5 | 5
Cofactor biosynthesis; molybdo... 5 | 5
Fermentation; pyruvate ferment... 5 | 5
Glycan biosynthesis; glycogen ... 5 | 5
Glycan metabolism; heparin bio... 5 | 5
Glycerolipid metabolism; triac... 5 | 5
Lipid metabolism; hydroperoxy ... 5 | 5
Lipid metabolism; mitochondria... 5 | 5
Alcohol metabolism; ethanol de... 4 | 4
Amino-sugar metabolism; N-acet... 4 | 4
Carbohydrate degradation; glyc... 4 | 4
Carbohydrate metabolism; trica... 4 | 4
Cofactor biosynthesis; coenzym... 4 | 4
Glycan metabolism; chondroitin... 4 | 4
Glycerolipid metabolism; triac... 4 | 4
Lipid metabolism; prostaglandi... 4 | 4
Lipid metabolism; steroid bios... 4 | 4
Phospholipid metabolism; CDP-d... 4 | 4
Phospholipid metabolism; phosp... 4 | 4
Polyol metabolism; glycerol de... 4 | 4
Protein modification; protein ... 4 | 4
Steroid biosynthesis; choleste... 4 | 4
Steroid biosynthesis; estrogen... 4 | 4
tRNA modification; 5-methoxyca... 4 | 4
Amine and polyamine biosynthes... 3 | 3
Amino-acid biosynthesis; L-hom... 3 | 3
Amino-acid biosynthesis; L-pro... 3 | 3
Amino-acid biosynthesis; S-ade... 3 | 3
Amino-acid degradation; L-tryp... 3 | 3
Amino-acid degradation; L-vali... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate metabolism; galac... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Genetic information processing... 3 | 3
Glycan biosynthesis; glycogen ... 3 | 3
Glycan biosynthesis; hyalurona... 3 | 3
Hormone biosynthesis; thyroid ... 3 | 3
Lipid metabolism; bile acid bi... 3 | 3
Metabolic intermediate biosynt... 3 | 3
Phospholipid metabolism; CDP-d... 3 | 3
Phospholipid metabolism; phosp... 3 | 3
Polyol metabolism; myo-inosito... 3 | 3
Protein modification; carbohyd... 3 | 3
Purine metabolism; 3',5'-cycli... 3 | 3
Purine metabolism; IMP biosynt... 3 | 3
Pyrimidine metabolism; CTP bio... 3 | 3
Pyrimidine metabolism; UMP bio... 3 | 3
Signal transduction; phosphati... 3 | 3
Amino-acid biosynthesis; L-cys... 2 | 2
Amino-acid biosynthesis; beta-... 2 | 2
Amino-acid degradation; L-alan... 2 | 2
Amino-acid degradation; L-leuc... 2 | 2
Amino-acid degradation; L-prol... 2 | 2
Aminoacyl-tRNA biosynthesis; s... 2 | 2
Aromatic compound metabolism; ... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Cofactor biosynthesis; adenosy... 2 | 2
Cofactor biosynthesis; iron-su... 2 | 2
Cofactor degradation; phylloqu... 2 | 2
Glycan metabolism; N-glycan me... 2 | 2
Isoprenoid biosynthesis; dimet... 2 | 2
Isoprenoid biosynthesis; farne... 2 | 2
Isoprenoid biosynthesis; geran... 2 | 2
Ketone metabolism; succinyl-Co... 2 | 2
Lipid metabolism; glycerolipid... 2 | 2
Nitrogen metabolism; urea cycl... 2 | 2
Nucleotide-sugar biosynthesis;... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Pigment biosynthesis; melanin ... 2 | 2
Porphyrin-containing compound ... 2 | 2
Purine metabolism; XMP biosynt... 2 | 2
Pyrimidine metabolism; dTTP bi... 2 | 2
Sulfur metabolism; sulfate ass... 2 | 2
tRNA modification; tRNA-queuos... 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Kelch-like protein 10 KLHL10 Tdark Non-IDG -0.62839 4.48 35
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 KCTD13 Tbio Non-IDG -0.85155 7.65 69