Development Level

Tbio 10 | 11,651
Tchem 4 | 1,388
Tclin 1 | 612

IMPC Phenotype

decreased circulating glucose ... 2 | 126
increased circulating sodium l... 2 | 71
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
decreased bone mineral content 1 | 151
decreased fasted circulating g... 1 | 65
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased fasted circulating g... 1 | 76

Disease

ovarian cancer 9 | 8,520
psoriasis 9 | 6,694
Carcinoma 8 | 11,493
glioblastoma 6 | 5,792
Astrocytoma, Pilocytic 5 | 3,081
osteosarcoma 5 | 7,950
adult high grade glioma 4 | 3,801
lung cancer 4 | 4,740
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 468
Anhidrosis 3 | 23
Breast cancer 3 | 3,578
Ichthyosis 3 | 56
aldosterone-producing adenoma 3 | 665
atypical teratoid / rhabdoid tumor 3 | 5,112
colon cancer 3 | 1,478
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
medulloblastoma, large-cell 3 | 6,241
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Alzheimer's disease 2 | 658
Autosomal recessive congenital ichthyosis 2 | 11
Cancer 2 | 2,499
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital ichthyosiform erythroderma 2 | 28
Congenital ichthyosis 2 | 3
Congenital non-bullous ichthyosiform erythroderma 2 | 7
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Distal sensory impairment of all modalities 2 | 7
Hereditary Sensory Autonomic Neuropathy, Type 1 2 | 4
Hereditary sensory neuropathy 2 | 11
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 2 | 3
Ichthyosiform erythroderma, Brocq congenital, nonbullous form 2 | 2
Ichthyosis, Congenital, Autosomal Recessive 2 2 | 3
Ichthyosis, Lamellar 2 | 4
Multiple myeloma 2 | 1,332
Neuropathy 2 | 261
Niemann-Pick disease 2 | 14
Palmoplantar keratosis 2 | 74
Self-Healing Collodion Baby 2 | 3
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis 2 | 2,010
urothelial carcinoma 2 | 318
Absence of eyebrows 1 | 31
Alopecia 1 | 115
Aplasia/Hypoplasia of the eyebrow 1 | 31
Autoamputation 1 | 2
Congenital deafness 1 | 185
Deafness 1 | 198
Decreased sensory nerve conduction velocities (NCV) 1 | 8
Dermatologic disorders 1 | 93
Dry skin 1 | 75
Gaucher's disease 1 | 26
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Hypohidrosis 1 | 34
Hypotrichosis 1 | 47
Ichthyoses 1 | 41
Keratitis 1 | 62
Lipid storage disease 1 | 8
Liver disease 1 | 237
Liver diseases 1 | 87
Lymphoma, Follicular 1 | 18
MYELODYSPLASTIC SYNDROME 1 | 53
Poor growth 1 | 114
Pruritus 1 | 58
Sensorineural Hearing Loss (disorder) 1 | 284
Sparse or absent eyebrows 1 | 31
Sparse/absent eyebrows 1 | 31
Thin, sparse hair 1 | 59
Tinea corporis 1 | 25
Very poor growth 1 | 114
X-linked cerebral adrenoleukodystrophy 1 | 116
Xerosis 1 | 75
facioscapulohumeral dystrophy 1 | 288
hair abnormalities (non-specific) 1 | 30
hearing impairment 1 | 199
interstitial lung disease 1 | 298

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Skin and soft tissues 15 | 17,230
Liver and Pancreas 14 | 16,750
Urinary Tract 14 | 16,678
Cardiovascular System 13 | 15,192
Respiratory system 13 | 16,393

Target Family

Enzyme 14 | 4,145
Transcription Factor 1 | 1,400

UniProt Pathway

Lipid metabolism; sphingolipid... 15 | 15
Protein modification; protein ... 390 | 390
Protein modification; protein ... 149 | 149
Glycolipid biosynthesis; glyco... 22 | 22
Protein modification; protein ... 17 | 17
Lipid metabolism; fatty acid b... 15 | 15
Lipid metabolism; fatty acid b... 13 | 13
Cofactor biosynthesis; ubiquin... 11 | 11
Glycan metabolism; heparan sul... 11 | 11
Carbohydrate biosynthesis; glu... 10 | 10
Purine metabolism; 3',5'-cycli... 9 | 9
Cofactor metabolism; retinol m... 8 | 8
Lipid metabolism; phospholipid... 7 | 7
One-carbon metabolism; tetrahy... 7 | 7
Protein modification; peptidyl... 7 | 7
Lipid metabolism; fatty acid m... 6 | 6
Lipid metabolism; polyunsatura... 6 | 6
Phospholipid metabolism; CDP-d... 6 | 6
Sulfur metabolism; glutathione... 6 | 6
tRNA modification; wybutosine-... 6 | 6
Carbohydrate metabolism; hexos... 5 | 5
Cofactor biosynthesis; molybdo... 5 | 5
Fermentation; pyruvate ferment... 5 | 5
Glycan biosynthesis; glycogen ... 5 | 5
Glycan metabolism; heparin bio... 5 | 5
Glycerolipid metabolism; triac... 5 | 5
Lipid metabolism; hydroperoxy ... 5 | 5
Lipid metabolism; mitochondria... 5 | 5
Steroid biosynthesis; estrogen... 5 | 5
Alcohol metabolism; ethanol de... 4 | 4
Amino-sugar metabolism; N-acet... 4 | 4
Carbohydrate degradation; glyc... 4 | 4
Cofactor biosynthesis; coenzym... 4 | 4
Glycan metabolism; chondroitin... 4 | 4
Glycerolipid metabolism; triac... 4 | 4
Lipid metabolism; prostaglandi... 4 | 4
Lipid metabolism; steroid bios... 4 | 4
Phospholipid metabolism; CDP-d... 4 | 4
Phospholipid metabolism; phosp... 4 | 4
Polyol metabolism; glycerol de... 4 | 4
Protein modification; protein ... 4 | 4
Steroid biosynthesis; choleste... 4 | 4
tRNA modification; 5-methoxyca... 4 | 4
Amine and polyamine biosynthes... 3 | 3
Amino-acid biosynthesis; L-pro... 3 | 3
Amino-acid biosynthesis; S-ade... 3 | 3
Amino-acid degradation; L-tryp... 3 | 3
Amino-acid degradation; L-vali... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate degradation; glyc... 3 | 3
Carbohydrate metabolism; galac... 3 | 3
Carbohydrate metabolism; trica... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Cofactor biosynthesis; NAD(+) ... 3 | 3
Genetic information processing... 3 | 3
Glycan biosynthesis; glycogen ... 3 | 3
Glycan biosynthesis; hyalurona... 3 | 3
Hormone biosynthesis; thyroid ... 3 | 3
Lipid metabolism; bile acid bi... 3 | 3
Metabolic intermediate biosynt... 3 | 3
Phospholipid metabolism; CDP-d... 3 | 3
Phospholipid metabolism; phosp... 3 | 3
Polyol metabolism; myo-inosito... 3 | 3
Protein modification; carbohyd... 3 | 3
Purine metabolism; 3',5'-cycli... 3 | 3
Purine metabolism; IMP biosynt... 3 | 3
Pyrimidine metabolism; CTP bio... 3 | 3
Pyrimidine metabolism; UMP bio... 3 | 3
Signal transduction; phosphati... 3 | 3
Amino-acid biosynthesis; L-cys... 2 | 2
Amino-acid biosynthesis; beta-... 2 | 2
Amino-acid degradation; L-alan... 2 | 2
Amino-acid degradation; L-leuc... 2 | 2
Aminoacyl-tRNA biosynthesis; s... 2 | 2
Aromatic compound metabolism; ... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate degradation; glyc... 2 | 2
Carbohydrate metabolism; trica... 2 | 2
Cofactor biosynthesis; adenosy... 2 | 2
Cofactor biosynthesis; iron-su... 2 | 2
Cofactor degradation; phylloqu... 2 | 2
Glycan metabolism; N-glycan me... 2 | 2
Isoprenoid biosynthesis; dimet... 2 | 2
Isoprenoid biosynthesis; farne... 2 | 2
Isoprenoid biosynthesis; geran... 2 | 2
Ketone metabolism; succinyl-Co... 2 | 2
Lipid metabolism; glycerolipid... 2 | 2
Nitrogen metabolism; urea cycl... 2 | 2
Nucleotide-sugar biosynthesis;... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Phospholipid metabolism; phosp... 2 | 2
Pigment biosynthesis; melanin ... 2 | 2
Porphyrin-containing compound ... 2 | 2
Purine metabolism; XMP biosynt... 2 | 2
Pyrimidine metabolism; dTTP bi... 2 | 2
Sulfur metabolism; glutathione... 2 | 2
Sulfur metabolism; sulfate ass... 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 3 SMPD3 Tbio Enzyme -1.84613 78.5 126
Galactosylceramide sulfotransferase GAL3ST1 Tbio Enzyme -1.20030 12.8 113
Serine palmitoyltransferase 3 SPTLC3 Tbio Enzyme -1.26166 18.5 24
Hydroperoxide isomerase ALOXE3 ALOXE3 Tbio Enzyme -1.51120 32.2 118
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase ST8SIA1 Tbio Enzyme -1.52525 35.4 40
Serine palmitoyltransferase small subunit A SPTSSA Tbio Enzyme -0.35857 2.20 0
Serine palmitoyltransferase small subunit B SPTSSB Tbio Enzyme -1.56467 34.6 3
Serine palmitoyltransferase 2 SPTLC2 Tchem Enzyme -1.70805 49.3 203
Serine palmitoyltransferase 1 SPTLC1 Tchem Enzyme -2.16711 143.2 285
Arachidonate 12-lipoxygenase, 12R-type ALOX12B Tbio Enzyme -1.33994 24.1 71