Development Level

Tbio 19 | 11,445
Tchem 4 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
preweaning lethality, complete... 2 | 979
abnormal blood vessel morpholo... 1 | 5
abnormal facial morphology 1 | 17
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal snout morphology 1 | 23
decreased circulating amylase ... 1 | 28
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
excessive tearing 1 | 2
increased grip strength 1 | 41
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
premature death 1 | 5

Disease

ovarian cancer 16 | 8,520
Carcinoma 14 | 11,493
osteosarcoma 13 | 7,950
psoriasis 8 | 6,694
Autosomal recessive predisposition 7 | 1,442
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
medulloblastoma, large-cell 6 | 6,241
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Neurodegenerative disease 5 | 414
atypical teratoid / rhabdoid tumor 5 | 5,112
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Charcot-Marie-Tooth disease 4 | 62
Distal sensory impairment 4 | 52
Failure to gain weight 4 | 365
Kidney cancer 4 | 2,613
Neuropathy 4 | 261
Pediatric failure to thrive 4 | 365
malignant mesothelioma 4 | 3,232
sonic hedgehog group medulloblastoma 4 | 467
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Cancer 3 | 2,499
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Epilepsy 3 | 792
Fetal Growth Retardation 3 | 189
Foot dorsiflexor weakness 3 | 27
Foot-drop 3 | 27
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Myositis 3 | 30
Reflex, Deep Tendon, Absent 3 | 92
Small head 3 | 374
adult high grade glioma 3 | 3,801
dermatomyositis 3 | 966
ependymoma 3 | 4,679
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Anemia 2 | 365
Avian influenza 2 | 7
Axial hypotonia 2 | 46
Axonal neuropathy 2 | 27
Breast cancer 2 | 3,578
Cerebral atrophy 2 | 178
Degenerative brain disorder 2 | 100
Distal amyotrophy 2 | 51
Elevated hepatic transaminases 2 | 81
Gait, Drop Foot 2 | 24
Hepatic enzyme increased 2 | 81
Hepatomegaly 2 | 285
Highly variable severity 2 | 157
Leukodystrophy 2 | 55
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Birth Weights 2 | 69
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Muscle hypotonia 2 | 571
Orbital separation excessive 2 | 244
Penile hypospadias 2 | 106
Peripheral axonal neuropathy 2 | 18
Pick disease 2 | 1,894
Premature Birth 2 | 77
Premature birth of newborn 2 | 67
Progressive disorder 2 | 142
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Seizures 2 | 596
Short stature 2 | 531
Slow progression 2 | 89
Small for gestational age (disorder) 2 | 69
Subclinical abnormal liver function tests 2 | 81
Supratentorial atrophy 2 | 94
Transaminases increased 2 | 81
Variable expressivity 2 | 157
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
interstitial lung disease 2 | 298
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819
Dirofilariasis 1 | 3
myopathy, lactic acidosis, and sideroblastic anemia 1 | 3

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Enzyme 14 | 4,145
Non-IDG 9 | 12,091
Kinase 1 | 634

UniProt Keyword

tRNA-binding 24 | 24
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS Tbio Enzyme -2.11362 120.5 120
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
Exportin-T XPOT Tbio Non-IDG -1.46210 29.6 86
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.61174 405.9 120
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial NSUN3 Tbio Enzyme -0.56275 3.91 88
Alanine--tRNA ligase, mitochondrial AARS2 Tbio Enzyme -1.57311 34.3 75
eIF-2-alpha kinase GCN2 EIF2AK4 Tchem Kinase -2.43702 276.5 301
Schlafen family member 11 SLFN11 Tbio Non-IDG -1.24198 19.1 21
Methionine--tRNA ligase, cytoplasmic MARS Tchem Enzyme -1.75152 50.3 88