Development Level

Tbio 59 | 11,445
Tdark 25 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 2 | 298
decreased grip strength 2 | 116
preweaning lethality, incomple... 2 | 499
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
excessive tearing 1 | 2
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased circulating aspartat... 1 | 15
increased grip strength 1 | 41
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
premature death 1 | 5

Disease

ovarian cancer 41 | 8,520
Carcinoma 39 | 11,493
osteosarcoma 36 | 7,950
lung cancer 28 | 4,740
medulloblastoma, large-cell 24 | 6,241
group 3 medulloblastoma 23 | 4,104
psoriasis 21 | 6,694
glioblastoma 15 | 5,792
atypical teratoid / rhabdoid tumor 14 | 5,112
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
colon cancer 9 | 1,478
malignant mesothelioma 9 | 3,232
primitive neuroectodermal tumor 9 | 3,035
ependymoma 8 | 4,679
progressive supranuclear palsy 8 | 676
Breast cancer 7 | 3,578
Microcephaly 7 | 166
acute myeloid leukemia 7 | 783
astrocytic glioma 7 | 2,597
invasive ductal carcinoma 7 | 2,951
oligodendroglioma 7 | 2,850
Multiple myeloma 6 | 1,332
adult high grade glioma 6 | 3,801
breast carcinoma 6 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Neurodegenerative disease 5 | 414
Pontocerebellar hypoplasia 5 | 36
acute quadriplegic myopathy 5 | 1,158
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
non-small cell lung cancer 5 | 2,890
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
Galloway Mowat syndrome 4 | 6
Galloway-Mowat syndrome 4 | 15
Lactic acidosis 4 | 51
Movement Disorders 4 | 55
Muscle hypotonia 4 | 571
Pontocerebellar Hypoplasia Type 2 4 | 5
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
sonic hedgehog group medulloblastoma 4 | 467
tuberculosis 4 | 2,010
Acidosis, Lactic 3 | 97
Atopic dermatitis 3 | 952
Cataract 7 3 | 32
Deglutition Disorders 3 | 132
Delayed speech and language development 3 | 112
Dull intelligence 3 | 645
Hyperreflexia 3 | 209
Hypertrophic Cardiomyopathy 3 | 117
Lactic acidemia 3 | 95
Language Delay 3 | 112
Leigh disease 3 | 100
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Metabolic acidosis 3 | 90
Muscle Spasticity 3 | 195
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Shipyard eye 3 | 15
Speech Delay 3 | 112
Speech impairment 3 | 112
Vision Disorders 3 | 6
astrocytoma 3 | 1,146
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Attention deficit hyperactivity disorder 2 | 278
Crohn's disease 2 | 321
Disease Models, Animal 2 | 155
Disease Progression 2 | 136
Dysarthria 2 | 192
Hypoglycemia 2 | 152
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Neoplasm Invasiveness 2 | 161
Pearson syndrome 2 | 19
Prostate cancer 2 | 175
Stomach Neoplasms 2 | 300
Waldenstrons macroglobulinemia 2 | 765
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
interstitial cystitis 2 | 2,312
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
posterior fossa group B ependymoma 2 | 416
primary Sjogren syndrome 2 | 735
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 83 | 16,909
Digestive Tract 83 | 17,369
Endocrine System 83 | 18,159
Female tissues 83 | 17,400
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Nervous System 83 | 16,725
Respiratory system 83 | 16,393
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Cardiovascular System 82 | 15,192

Target Family

Enzyme 69 | 4,145
Non-IDG 14 | 12,091
Kinase 1 | 634

UniProt Keyword

tRNA processing 84 | 84
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Probable tRNA(His) guanylyltransferase THG1L Tbio Enzyme -0.60206 3.69 71
tRNA pseudouridine synthase A PUS1 Tbio Enzyme -1.66676 46.4 119
Pseudouridylate synthase 7 homolog PUS7 Tbio Enzyme -1.01773 8.78 58
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 Tbio Enzyme -1.13540 12.8 55
EKC/KEOPS complex subunit TPRKB TPRKB Tbio Non-IDG -0.79500 4.88 134
tRNA-splicing ligase RtcB homolog RTCB Tbio Enzyme -1.75651 56.6 144
Protein MTO1 homolog, mitochondrial MTO1 Tbio Non-IDG -2.45185 260.9 53
Protein archease ZBTB8OS Tbio Enzyme -2.35665 223.8 28
G-rich sequence factor 1 GRSF1 Tbio Non-IDG -1.05585 12.0 138