Development Level

Tbio 50 | 10,625
Tdark 33 | 7,003
Tchem 1 | 1,890

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 2 | 226
decreased grip strength 2 | 123
abnormal cranium morphology 1 | 32
abnormal humerus morphology 1 | 11
abnormal iron homeostasis 1 | 1
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal posture 1 | 5
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased CD4-positive, CD25-p... 1 | 24
decreased body weight 1 | 174
decreased circulating amylase ... 1 | 24
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased mean corpuscular vol... 1 | 50
decreased total retina thickne... 1 | 20
excessive tearing 1 | 2
hyperactivity 1 | 108
increased KLRG1-positive NK ce... 1 | 9
increased NK cell number 1 | 19
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased grip strength 1 | 83
increased or absent threshold ... 1 | 128
premature death 1 | 5
preweaning lethality, incomple... 1 | 260
thrombocytopenia 1 | 46

Disease

ovarian cancer 40 | 8,484
osteosarcoma 33 | 7,933
lung cancer 27 | 4,466
medulloblastoma, large-cell 24 | 6,234
group 3 medulloblastoma 20 | 2,254
psoriasis 20 | 6,685
glioblastoma 14 | 5,572
atypical teratoid / rhabdoid tumor 10 | 4,369
Intellectual disability 9 | 573
Pick disease 9 | 1,893
colon cancer 9 | 1,475
malignant mesothelioma 9 | 3,162
primitive neuroectodermal tumor 8 | 3,031
progressive supranuclear palsy 8 | 674
acute myeloid leukemia 7 | 780
astrocytic glioma 7 | 2,241
oligodendroglioma 7 | 2,849
Breast cancer 6 | 3,094
Multiple myeloma 6 | 1,327
adult high grade glioma 6 | 2,148
breast carcinoma 6 | 1,614
invasive ductal carcinoma 6 | 2,950
Microcephaly 5 | 149
Pontocerebellar hypoplasia 5 | 29
acute quadriplegic myopathy 5 | 1,157
diabetes mellitus 5 | 1,663
ependymoma 5 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
non-small cell lung cancer 5 | 2,798
pediatric high grade glioma 5 | 2,712
posterior fossa group B ependymoma 5 | 1,530
Lactic acidosis 4 | 42
Neurodegenerative disease 4 | 383
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
pilocytic astrocytoma 4 | 3,086
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Atopic dermatitis 3 | 944
Deglutition Disorders 3 | 4
Dyskeratosis congenita 3 | 24
Inflammatory Bowel Diseases 3 | 87
Movement Disorders 3 | 21
Pontocerebellar Hypoplasia Type 2 3 | 4
Rheumatoid Arthritis 3 | 1,160
Shipyard eye 3 | 14
Vision Disorders 3 | 5
astrocytoma 3 | 1,493
atypical teratoid/rhabdoid tumor 3 | 1,095
group 4 medulloblastoma 3 | 1,875
medulloblastoma 3 | 1,524
pancreatic cancer 3 | 2,300
pancreatic carcinoma 3 | 567
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Cardiomyopathy 2 | 110
Crohn Disease 2 | 97
Crohn's disease 2 | 304
Disease Progression 2 | 125
Leigh disease 2 | 81
Nonsyndromic deafness 2 | 121
Pearson syndrome 2 | 17
Phenylketonuria 2 | 18
Precancerous Conditions 2 | 69
Prostate cancer 2 | 172
Stomach Neoplasms 2 | 282
Systemic scleroderma 2 | 66
Waldenstrons macroglobulinemia 2 | 765
ductal carcinoma in situ 2 | 1,745
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,713
non primary Sjogren syndrome sicca 2 | 840
primary Sjogren syndrome 2 | 789
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
Acute monocytic leukemia 1 | 11
Agoraphobia 1 | 16
COPD 1 | 113
Cardiac arrest 1 | 26
Celiac disease 1 | 112
Cerebellar Ataxia 1 | 72
Ehlers-Danlos syndrome 1 | 42
Fibrosis 1 | 40
Generalized anxiety disorder 1 | 29
Gestational Diabetes 1 | 17
Kidney cancer 1 | 118
Lung squamous cell carcinoma 1 | 10
Metabolic acidosis 1 | 49
Osteoarthritis 1 | 96
Pontocerebellar Hypoplasia Type 1 1 | 5
Primary microcephaly 1 | 6
Renal agenesis 1 | 25
Seizure Adverse Event 1 | 19
Sideroblastic anemia 1 | 18
cartilage-hair hypoplasia 1 | 7
ovarian neoplasm 1 | 97

Tissue

Blood and immune system 84 | 17,995
Cardiovascular System 84 | 17,958
Digestive Tract 84 | 18,473
Nervous System 84 | 18,561
Urinary Tract 84 | 18,444
Endocrine System 83 | 18,512
Female tissues 83 | 18,647
Liver and Pancreas 83 | 18,136
Male tissues 83 | 17,969
Skin and soft tissues 83 | 18,115
Respiratory system 82 | 17,484

Target Family

Enzyme 69 | 4,146
Non-IDG 14 | 11,971
Kinase 1 | 634

UniProt Keyword

tRNA processing 84 | 84
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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