Development Level

Tbio 185 | 10,625
Tdark 52 | 7,003
Tchem 18 | 1,890

Collection

Kinase: IDG Consortium (Complete/Control) 2 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 633
embryonic lethality prior to t... 8 | 187
embryonic lethality prior to o... 7 | 148
abnormal behavior 3 | 226
decreased grip strength 3 | 123
increased fasted circulating g... 3 | 68
increased or absent threshold ... 3 | 128
preweaning lethality, incomple... 3 | 260
abnormal coat-hair pigmentatio... 2 | 54
decreased leukocyte cell numbe... 2 | 54
decreased neutrophil cell numb... 2 | 37
hyperactivity 2 | 108
increased grip strength 2 | 83
thrombocytosis 2 | 23
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal esophagus morphology 1 | 4
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
aorta dilation 1 | 3
cardiovascular system phenotyp... 1 | 35
decreased CD5-positive gamma-d... 1 | 3
decreased IgG2b level 1 | 1
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased cervical vertebrae n... 1 | 12
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased memory-marker CD4-ne... 1 | 4
decreased monocyte cell number 1 | 28
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased CD4-negative NK T ce... 1 | 4
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
oligodactyly 1 | 14
sparse hair 1 | 6

Disease

ovarian cancer 166 | 8,491
osteosarcoma 123 | 7,933
medulloblastoma, large-cell 89 | 6,234
psoriasis 85 | 6,685
glioblastoma 74 | 5,572
group 3 medulloblastoma 74 | 2,254
lung cancer 73 | 4,473
Multiple myeloma 59 | 1,327
oligodendroglioma 57 | 2,849
atypical teratoid / rhabdoid tumor 54 | 4,369
ependymoma 52 | 2,514
acute quadriplegic myopathy 49 | 1,157
primitive neuroectodermal tumor 47 | 3,031
malignant mesothelioma 44 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
astrocytoma 41 | 1,493
Pick disease 39 | 1,893
dermatomyositis 38 | 966
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
Breast cancer 36 | 3,098
astrocytic glioma 34 | 2,241
diabetes mellitus 34 | 1,663
Waldenstrons macroglobulinemia 33 | 764
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,795
pediatric high grade glioma 31 | 2,712
non-small cell lung cancer 29 | 2,798
subependymal giant cell astrocytoma 28 | 2,287
Carcinoma 27 | 2,147
adult high grade glioma 27 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
juvenile dermatomyositis 26 | 1,189
lung adenocarcinoma 26 | 2,714
invasive ductal carcinoma 24 | 2,950
progressive supranuclear palsy 24 | 674
atypical teratoid/rhabdoid tumor 22 | 1,095
acute myeloid leukemia 21 | 785
pancreatic cancer 21 | 2,300
sonic hedgehog group medulloblastoma 20 | 1,482
Cancer 19 | 2,346
pilocytic astrocytoma 19 | 3,086
Intellectual disability 18 | 573
group 4 medulloblastoma 18 | 1,875
tuberculosis and treatment for 6 months 16 | 686
Muscular atrophy 15 | 67
Rheumatoid Arthritis 15 | 1,170
non primary Sjogren syndrome sicca 15 | 840
pituitary cancer 15 | 1,972
Amyotrophic Lateral Sclerosis 14 | 432
breast carcinoma 13 | 1,614
Gaucher disease type 1 12 | 171
colon cancer 12 | 1,475
nasopharyngeal carcinoma 12 | 1,056
posterior fossa group A ependymoma 11 | 1,511
Spinal muscular atrophy 10 | 24
aldosterone-producing adenoma 10 | 664
spina bifida 10 | 1,064
hepatocellular carcinoma 9 | 550
primary pancreatic ductal adenocarcinoma 9 | 1,271
HIV Infections 8 | 99
adrenocortical carcinoma 8 | 1,427
hereditary spastic paraplegia 8 | 313
lung carcinoma 8 | 2,844
posterior fossa group B ependymoma 8 | 1,530
Alzheimer's disease 7 | 644
Down syndrome 7 | 548
Polycystic Ovary Syndrome 7 | 334
Retinitis pigmentosa 7 | 156
Schizophrenia 7 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
cystic fibrosis 7 | 1,670
ductal carcinoma in situ 7 | 1,745
gastric cancer 7 | 436
medulloblastoma 7 | 1,524
tuberculosis 7 | 1,563
Atopic dermatitis 6 | 944
Duchenne muscular dystrophy 6 | 602
Neurodegenerative disease 6 | 383
interstitial cystitis 6 | 2,299
pancreatic carcinoma 6 | 567
primary Sjogren syndrome 6 | 788
Azoospermia 5 | 89
Epilepsy 5 | 346
Frontotemporal dementia 5 | 47
Mammary Neoplasms 5 | 410
Microcephaly 5 | 149
Myotonic dystrophy type 1 5 | 16
Subcutaneous panniculitis-like T-cell lymphoma 5 | 16
glioblastoma multiforme 5 | 347
relapsing-remitting multiple sclerosis 5 | 18
ulcerative colitis 5 | 2,087
Animal Mammary Neoplasms 4 | 135
Lupus erythematosus 4 | 80
Mammary Neoplasms, Experimental 4 | 149
Melanoma 4 | 261
Nager acrofacial dysostosis 4 | 21
Spinocerebellar ataxia type 1 4 | 16
Stomach Neoplasms 4 | 282
gastric carcinoma 4 | 832
mucosa-associated lymphoid tissue lymphoma 4 | 480
non diabetic and post-ischemic heart failure 3 | 200

Tissue

Blood and immune system 253 | 17,994
Female tissues 253 | 18,646
Male tissues 253 | 17,968
Endocrine System 252 | 18,511
Urinary Tract 250 | 18,443
Digestive Tract 249 | 18,472
Cardiovascular System 248 | 17,957
Liver and Pancreas 248 | 18,135
Nervous System 248 | 18,560
Respiratory system 247 | 17,483
Skin and soft tissues 245 | 18,114

Target Family

Non-IDG 213 | 11,969
Enzyme 29 | 4,146
Epigenetic 5 | 242
Kinase 5 | 634
Transcription Factor 3 | 1,400

UniProt Keyword

mRNA splicing 255 | 255
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Protein quaking QKI Tbio Non-IDG -1.81649 63.7 254
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
RNA-binding motif protein, Y chromosome, family 1 member E RBMY1E Tdark Non-IDG 0.00000 15
Protein SCAF8 SCAF8 Tdark Non-IDG -0.59471 3.85 53
Protein IWS1 homolog IWS1 Tdark Non-IDG -0.56293 3.84 50
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.31776 194.4 161
Sodium channel modifier 1 SCNM1 Tdark Non-IDG -0.61195 4.75 38