Development Level

Tbio 212 | 11,651
Tdark 42 | 6,593
Tchem 10 | 1,388

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 37 | 979
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 10 | 278
abnormal behavior 5 | 298
increased startle reflex 5 | 112
embryonic growth retardation 4 | 106
hypoactivity 4 | 132
preweaning lethality, incomple... 4 | 499
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo size 3 | 220
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
hyperactivity 3 | 148
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
abnormal embryo turning 2 | 31
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased grip strength 2 | 41
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal esophagus morphology 1 | 5
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
aorta dilation 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased IgE level 1 | 6
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
edema 1 | 59
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

ovarian cancer 172 | 8,520
Carcinoma 170 | 11,493
osteosarcoma 128 | 7,950
group 3 medulloblastoma 99 | 4,104
medulloblastoma, large-cell 94 | 6,241
psoriasis 90 | 6,694
lung cancer 81 | 4,740
glioblastoma 80 | 5,792
atypical teratoid / rhabdoid tumor 71 | 5,112
ependymoma 68 | 4,679
Multiple myeloma 61 | 1,332
oligodendroglioma 60 | 2,850
acute quadriplegic myopathy 51 | 1,158
primitive neuroectodermal tumor 51 | 3,035
malignant mesothelioma 45 | 3,232
astrocytic glioma 44 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
adult high grade glioma 43 | 3,801
Breast cancer 41 | 3,578
Kidney cancer 41 | 2,613
Pick disease 40 | 1,894
dermatomyositis 40 | 966
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
astrocytoma 36 | 1,146
diabetes mellitus 36 | 1,728
Waldenstrons macroglobulinemia 33 | 765
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
non-small cell lung cancer 29 | 2,890
subependymal giant cell astrocytoma 29 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
juvenile dermatomyositis 28 | 1,187
Intellectual disability 27 | 1,016
invasive ductal carcinoma 27 | 2,951
lung adenocarcinoma 27 | 2,716
progressive supranuclear palsy 25 | 676
pancreatic cancer 23 | 2,398
Astrocytoma, Pilocytic 21 | 3,081
acute myeloid leukemia 21 | 783
Cancer 19 | 2,499
Rheumatoid arthritis 17 | 1,191
pediatric high grade glioma 17 | 1,064
Muscular atrophy 16 | 71
breast carcinoma 16 | 1,638
non primary Sjogren syndrome sicca 16 | 891
Amyotrophic lateral sclerosis 15 | 451
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
pituitary cancer 15 | 1,972
Gaucher disease type 1 14 | 180
group 4 medulloblastoma 14 | 1,855
tuberculosis and treatment for 6 months 14 | 409
colon cancer 13 | 1,478
Spinal muscular atrophy 12 | 34
nasopharyngeal carcinoma 12 | 1,058
Schizophrenia 11 | 1,160
spina bifida 11 | 1,074
Conductive hearing loss 10 | 123
Epilepsy 10 | 792
aldosterone-producing adenoma 10 | 665
tuberculosis 10 | 2,010
Anteverted nostril 9 | 191
Broad flat nasal bridge 9 | 236
Nasal bridge wide 9 | 236
atypical teratoid/rhabdoid tumor 9 | 357
hepatocellular carcinoma 9 | 547
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cleft Palate 8 | 271
Cognitive delay 8 | 608
Global developmental delay 8 | 608
HIV Infections 8 | 102
Hypogonadism 8 | 173
Mental and motor retardation 8 | 608
Retinitis Pigmentosa 8 | 226
Short stature 8 | 531
Small head 8 | 374
Uranostaphyloschisis 8 | 167
adrenocortical carcinoma 8 | 1,428
cystic fibrosis 8 | 1,696
hereditary spastic paraplegia 8 | 318
lung carcinoma 8 | 2,843
Alzheimer's disease 7 | 658
Autosomal recessive predisposition 7 | 1,442
Blind Vision 7 | 111
Blindness, Legal 7 | 110
Cataract 7 | 297
Hypoplastic mandible condyle 7 | 275
Lens Opacities 7 | 231
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Nystagmus 7 | 317
Obesity 7 | 678
Polycystic ovary syndrome 7 | 360
Sensorineural Hearing Loss (disorder) 7 | 284
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
ductal carcinoma in situ 7 | 1,745
gastric cancer 7 | 459
sonic hedgehog group medulloblastoma 7 | 467

Tissue

Endocrine System 262 | 18,159
Male tissues 259 | 17,142
Female tissues 258 | 17,400
Urinary Tract 258 | 16,678
Digestive Tract 257 | 17,369
Nervous System 257 | 16,725
Respiratory system 257 | 16,393
Skin and soft tissues 257 | 17,230
Liver and Pancreas 255 | 16,750
Blood and immune system 254 | 16,909
Cardiovascular System 254 | 15,192

Target Family

Non-IDG 219 | 12,091
Enzyme 32 | 4,145
Epigenetic 5 | 242
Kinase 5 | 634
Transcription Factor 3 | 1,400

UniProt Keyword

mRNA splicing 264 | 264
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
RNA-binding protein 39 RBM39 Tbio Non-IDG -0.95639 9.80 199
U6 snRNA-associated Sm-like protein LSm5 LSM5 Tdark Non-IDG -0.98876 8.80 46
RNA binding protein fox-1 homolog 1 RBFOX1 Tbio Non-IDG -2.00815 99.2 207
Protein ecdysoneless homolog ECD Tbio Non-IDG -0.72245 9.93 113
Pre-mRNA-splicing factor SYF2 SYF2 Tbio Non-IDG -1.04825 13.2 124
Corepressor interacting with RBPJ 1 CIR1 Tdark Non-IDG -0.30821 2.08 91
Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 Tbio Enzyme -0.78829 5.38 130
Probable ATP-dependent RNA helicase DDX23 DDX23 Tbio Enzyme -1.24669 18.6 167