Development Level

Tclin 14 | 612
Tchem 5 | 1,388
Tbio 2 | 11,651

IMPC Phenotype

enlarged heart 4 | 210
abnormal heart morphology 2 | 162
enlarged spleen 2 | 41
abnormal behavior 1 | 298
abnormal duodenum morphology 1 | 4
abnormal skin morphology 1 | 50
abnormal whole-body plethysmog... 1 | 4
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
enlarged uterus 1 | 11
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood uric acid leve... 1 | 5
increased cellular hemoglobin ... 1 | 1
increased circulating potassiu... 1 | 29
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
macrophthalmia 1 | 2
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15

Disease

Carcinoma 18 | 11,493
Atrial Fibrillation 15 | 124
Chronic heart failure 15 | 46
Myocardial Perfusion Imaging Adjunct 15 | 25
Platelet Aggregation Inhibition 15 | 22
Prevention of Cerebral Thrombosis 15 | 29
medulloblastoma, large-cell 10 | 6,241
Autosomal recessive predisposition 9 | 1,442
Kidney cancer 9 | 2,613
Electroretinogram abnormal 8 | 95
Photodysphoria 8 | 121
Photophobia 8 | 121
Retinitis Pigmentosa 8 | 226
invasive ductal carcinoma 8 | 2,951
Abnormality of retinal pigmentation 7 | 111
Breast cancer 7 | 3,578
Difficulties with night vision 7 | 87
Night Blindness 7 | 101
Retinal pigment epithelial abnormality 7 | 111
ependymoma 7 | 4,679
malignant mesothelioma 7 | 3,232
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
Hypogonadism 6 | 173
Impotence 6 | 46
Nystagmus 6 | 317
atypical teratoid / rhabdoid tumor 6 | 5,112
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
lung adenocarcinoma 6 | 2,716
lung cancer 6 | 4,740
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Blind Vision 5 | 111
Blindness 5 | 88
Blindness, Legal 5 | 110
Cataract 5 | 297
Fundus dystrophy 5 | 83
Lens Opacities 5 | 231
Low Vision 5 | 174
Obesity 5 | 678
Visual Impairment 5 | 174
adult high grade glioma 5 | 3,801
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
psoriasis 5 | 6,694
ulcerative colitis 5 | 1,819
Abnormality of the retinal vasculature 4 | 59
Achromatopsia 4 | 16
Anteverted nostril 4 | 191
Astrocytoma, Pilocytic 4 | 3,081
Atypical scarring of skin 4 | 62
Broad flat nasal bridge 4 | 236
Color vision defect 4 | 33
Conductive hearing loss 4 | 123
Congenital anomaly of testis 4 | 52
Congenital hypoplasia of penis 4 | 176
Dull intelligence 4 | 645
Dyschromatopsia 4 | 8
Exotropia 4 | 35
Glaucoma 4 | 239
Hyperinsulinism 4 | 133
Hyperopia 4 | 70
Intellectual disability 4 | 1,016
Keratoconus 4 | 113
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nasal bridge wide 4 | 236
Night blindness, progressive 4 | 51
Nystagmus, continuous pendular 4 | 14
Ophthalmoplegia 4 | 106
Optic Atrophy 4 | 242
Pendular Nystagmus 4 | 14
Pick disease 4 | 1,894
Poor school performance 4 | 645
Reduced visual acuity 4 | 63
Retinal Degeneration 4 | 106
Sensorineural Hearing Loss (disorder) 4 | 284
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
glioblastoma 4 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
medulloblastoma 4 | 720
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
Abnormal color vision 3 | 31
Asthma 3 | 385
Color vision defect, severe 3 | 31
Cone dystrophy 3 | 71
Hypertensive disease 3 | 292
Increase in blood pressure 3 | 119
Pulmonary hypertension 3 | 86
cone-rod dystrophy 3 | 59
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
tuberculosis 3 | 2,010

Tissue

Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Nervous System 21 | 16,725
Urinary Tract 21 | 16,678
Blood and immune system 20 | 16,909
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Male tissues 19 | 17,142
Cardiovascular System 18 | 15,192

Target Family

Enzyme 16 | 4,145
Ion Channel 3 | 344
Kinase 2 | 634

UniProt Keyword

cGMP 21 | 21
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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