Development Level

Tchem 105 | 1,388
Tbio 85 | 11,651
Tclin 13 | 612
Tdark 12 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
preweaning lethality, complete... 5 | 979
abnormal seminal vesicle morph... 4 | 114
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
abnormal vibrissa morphology 3 | 25
decreased bone mineral content 3 | 151
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased vertical activity 3 | 208
hypoactivity 3 | 132
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
cataract 2 | 92
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating chloride... 2 | 30
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
prolonged ST segment 2 | 36
abnormal body wall morphology 1 | 9
abnormal esophagus morphology 1 | 5
abnormal facial morphology 1 | 17
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal lymph node morphology 1 | 3
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
anophthalmia 1 | 33
aorta stenosis 1 | 2
athymia 1 | 2
brachydactyly 1 | 19
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
enlarged liver 1 | 2
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
male infertility 1 | 123
premature death 1 | 5
prolonged QT interval 1 | 38
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 147 | 11,493
ovarian cancer 95 | 8,520
psoriasis 89 | 6,694
osteosarcoma 82 | 7,950
Cancer 76 | 2,499
lung cancer 67 | 4,740
glioblastoma 64 | 5,792
lung carcinoma 60 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,955
pancreatic cancer 52 | 2,398
lung adenocarcinoma 50 | 2,716
Breast cancer 47 | 3,578
diabetes mellitus 47 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
malignant mesothelioma 47 | 3,232
medulloblastoma, large-cell 46 | 6,241
non-small cell lung cancer 44 | 2,890
adult high grade glioma 43 | 3,801
atypical teratoid / rhabdoid tumor 42 | 5,112
interstitial cystitis 42 | 2,312
invasive ductal carcinoma 42 | 2,951
ulcerative colitis 42 | 1,819
ependymoma 41 | 4,679
cystic fibrosis 40 | 1,696
Astrocytoma, Pilocytic 37 | 3,081
Autosomal recessive predisposition 37 | 1,442
Kidney cancer 33 | 2,613
cutaneous lupus erythematosus 31 | 1,057
oligodendroglioma 30 | 2,850
subependymal giant cell astrocytoma 30 | 2,287
group 3 medulloblastoma 28 | 4,104
tuberculosis 28 | 2,010
Atopic dermatitis 27 | 952
Liver Cirrhosis, Experimental 25 | 769
colon cancer 24 | 1,478
ductal carcinoma in situ 24 | 1,745
breast carcinoma 23 | 1,638
primary pancreatic ductal adenocarcinoma 23 | 1,109
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Alzheimer's disease 21 | 658
Hypertension 21 | 396
primitive neuroectodermal tumor 21 | 3,035
astrocytic glioma 20 | 2,597
esophageal adenocarcinoma 20 | 737
pituitary cancer 20 | 1,972
Arthritis 19 | 290
Multiple myeloma 19 | 1,332
Schizophrenia 19 | 1,160
adrenocortical carcinoma 19 | 1,428
primary Sjogren syndrome 19 | 735
Atherosclerosis 18 | 291
Coronary artery disease 18 | 268
Melanoma 18 | 711
Pancreatitis 18 | 123
active Crohn's disease 18 | 922
gastric carcinoma 18 | 807
nasopharyngeal carcinoma 18 | 1,058
Cerebrovascular disease 17 | 238
Kidney disease 17 | 430
Obesity 17 | 678
Vascular disease 17 | 319
group 4 medulloblastoma 17 | 1,855
juvenile dermatomyositis 17 | 1,187
Bipolar Disorder 15 | 666
Duchenne muscular dystrophy 15 | 601
Rheumatoid arthritis 15 | 1,191
Myocardial Infarction 14 | 151
Skin cancer 14 | 469
mucosa-associated lymphoid tissue lymphoma 14 | 484
pediatric high grade glioma 14 | 1,064
periodontitis 14 | 293
Heart disease 13 | 306
Neurodegenerative disease 13 | 414
Prostatic Neoplasms 13 | 495
head and neck cancer and chronic obstructive pulmonary disease 13 | 239
Asthma 12 | 385
active ulcerative colitis 12 | 764
astrocytoma 12 | 1,146
non primary Sjogren syndrome sicca 12 | 891
Diarrhea 11 | 253
Multiple Sclerosis 11 | 540
Waldenstrons macroglobulinemia 11 | 765
spina bifida 11 | 1,074
Breast Neoplasms 10 | 445
Down syndrome 10 | 499
Endometriosis 10 | 540
Hypertensive disease 10 | 292
Lung disease 10 | 142
Mammary Neoplasms 10 | 425
Neoplasm Invasiveness 10 | 161
Osteoporosis 10 | 363
Pulmonary embolism 10 | 55
Thrombophilia 10 | 38
acute myeloid leukemia 10 | 783
pancreatic carcinoma 10 | 562
Brain Ischemia 9 | 110
Liver carcinoma 9 | 240
Pick disease 9 | 1,894
dermatomyositis 9 | 966

Tissue

Female tissues 209 | 17,400
Endocrine System 208 | 18,159
Digestive Tract 207 | 17,369
Skin and soft tissues 203 | 17,230
Blood and immune system 200 | 16,909
Male tissues 199 | 17,142
Urinary Tract 199 | 16,678
Liver and Pancreas 196 | 16,750
Nervous System 190 | 16,725
Respiratory system 189 | 16,393
Cardiovascular System 162 | 15,192

Target Family

Enzyme 201 | 4,145
Non-IDG 14 | 12,091

UniProt Keyword

Zymogen 215 | 215
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Cathepsin E CTSE Tchem Enzyme -2.33724 227.7 192
Chymotrypsin-like protease CTRL-1 CTRL Tchem Enzyme -3.14577 1283.5 150
Disintegrin and metalloproteinase domain-containing protein 21 ADAM21 Tdark Enzyme -0.76419 6.37 28
Carboxypeptidase A5 CPA5 Tbio Enzyme -0.97002 10.1 64
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Testisin PRSS21 Tbio Enzyme -2.09237 118.4 46