Development Level

Tchem 112 | 1,890
Tbio 76 | 10,625
Tdark 14 | 7,003
Tclin 13 | 602

IMPC Term

preweaning lethality, incomple... 5 | 260
enlarged heart 4 | 111
preweaning lethality, complete... 4 | 633
abnormal behavior 3 | 226
abnormal seminal vesicle morph... 3 | 47
abnormal vibrissa morphology 3 | 17
decreased body length 3 | 108
decreased total body fat amoun... 3 | 186
short tibia 3 | 82
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
decreased prepulse inhibition 2 | 52
hyperactivity 2 | 108
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
abnormal body wall morphology 1 | 7
abnormal embryo size 1 | 112
abnormal esophagus morphology 1 | 4
abnormal eye morphology 1 | 38
abnormal facial morphology 1 | 9
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal lymph node morphology 1 | 3
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin coloration 1 | 18
abnormal snout morphology 1 | 18
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
anophthalmia 1 | 20
athymia 1 | 1
brachydactyly 1 | 2
cataract 1 | 26
cleft palate 1 | 6
convulsive seizures 1 | 11
decreased B cell number 1 | 30
decreased CD11b-low dendritic ... 1 | 3
decreased CD4-positive, CD25-p... 1 | 24
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased food intake 1 | 6
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased pro-B cell number 1 | 2
decreased respiratory quotient 1 | 12
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged liver 1 | 3
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased CD11b-high dendritic... 1 | 5
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased pro-B cell number 1 | 1
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
premature death 1 | 5
small testis 1 | 37
straub tail 1 | 26
tremors 1 | 34

Disease

ovarian cancer 95 | 8,484
psoriasis 89 | 6,685
osteosarcoma 81 | 7,933
Cancer 70 | 2,346
lung cancer 66 | 4,466
glioblastoma 63 | 5,572
lung carcinoma 60 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,956
pancreatic cancer 51 | 2,300
lung adenocarcinoma 50 | 2,713
ulcerative colitis 50 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,988
malignant mesothelioma 46 | 3,162
medulloblastoma, large-cell 46 | 6,234
diabetes mellitus 43 | 1,663
interstitial cystitis 42 | 2,299
invasive ductal carcinoma 42 | 2,950
non-small cell lung cancer 42 | 2,798
cystic fibrosis 40 | 1,665
atypical teratoid / rhabdoid tumor 38 | 4,369
pilocytic astrocytoma 38 | 3,086
Breast cancer 33 | 3,094
cutaneous lupus erythematosus 31 | 1,056
Carcinoma 30 | 2,147
oligodendroglioma 30 | 2,849
pediatric high grade glioma 30 | 2,712
subependymal giant cell astrocytoma 30 | 2,287
Atopic dermatitis 27 | 944
adult high grade glioma 27 | 2,148
tuberculosis 27 | 1,557
primary pancreatic ductal adenocarcinoma 26 | 1,271
colon cancer 24 | 1,475
ductal carcinoma in situ 24 | 1,745
breast carcinoma 23 | 1,614
Alzheimer's disease 21 | 644
posterior fossa group A ependymoma 21 | 1,511
primitive neuroectodermal tumor 21 | 3,031
esophageal adenocarcinoma 20 | 737
pituitary cancer 20 | 1,972
primary Sjogren syndrome 20 | 789
Multiple myeloma 19 | 1,327
adrenocortical carcinoma 19 | 1,427
gastric carcinoma 19 | 832
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
Arthritis 18 | 248
Atherosclerosis 18 | 275
Vascular disease 18 | 281
active Crohn's disease 18 | 918
astrocytic glioma 18 | 2,241
nasopharyngeal carcinoma 18 | 1,056
Cerebrovascular disease 17 | 231
Hypertension 17 | 287
Obesity 17 | 616
Pancreatitis 17 | 97
group 4 medulloblastoma 17 | 1,875
juvenile dermatomyositis 17 | 1,189
posterior fossa group B ependymoma 17 | 1,530
Kidney disease 16 | 396
ependymoma 16 | 2,514
Coronary artery disease 15 | 240
Duchenne muscular dystrophy 15 | 602
IGA Glomerulonephritis 15 | 454
Rheumatoid Arthritis 14 | 1,160
astrocytoma 14 | 1,493
group 3 medulloblastoma 14 | 2,254
inflammatory breast cancer 14 | 404
mucosa-associated lymphoid tissue lymphoma 14 | 480
Myocardial Infarction 13 | 126
Prostatic Neoplasms 13 | 471
head and neck cancer and chronic obstructive pulmonary disease 13 | 237
Down syndrome 12 | 548
Heart disease 12 | 279
Lung disease 12 | 132
Neurodegenerative disease 12 | 383
periodontitis 12 | 269
sonic hedgehog group medulloblastoma 12 | 1,482
Waldenstrons macroglobulinemia 11 | 765
atypical teratoid/rhabdoid tumor 11 | 1,095
non primary Sjogren syndrome sicca 11 | 840
spina bifida 11 | 1,064
Asthma 10 | 349
Endometriosis 10 | 535
Mammary Neoplasms 10 | 410
Neoplasm Invasiveness 10 | 127
acute myeloid leukemia 10 | 780
non-small cell lung carcinoma 10 | 413
pancreatic carcinoma 10 | 567
Diarrhea 9 | 155
Hypertensive disease 9 | 193
Liver carcinoma 9 | 217
Periodontal disease 9 | 37
Pick disease 9 | 1,893
Thrombophilia 9 | 36
dermatomyositis 9 | 933
medulloblastoma 9 | 1,524
Disseminated intravascular coagulation 8 | 32
Multiple Sclerosis 8 | 498
acute quadriplegic myopathy 8 | 1,157
head and neck cancer 8 | 270

Tissue

Female tissues 213 | 18,647
Digestive Tract 212 | 18,473
Endocrine System 211 | 18,512
Urinary Tract 211 | 18,444
Blood and immune system 210 | 17,995
Liver and Pancreas 210 | 18,136
Male tissues 210 | 17,969
Nervous System 210 | 18,561
Skin and soft tissues 209 | 18,115
Cardiovascular System 207 | 17,958
Respiratory system 206 | 17,484

Target Family

Enzyme 201 | 4,146
Non-IDG 14 | 11,971

UniProt Keyword

Zymogen 215 | 215
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Ovochymase-2 OVCH2 Tdark Enzyme 0.00000 0
Transmembrane protease serine 7 TMPRSS7 Tdark Enzyme 0.24 0.97 63
Ovochymase-1 OVCH1 Tdark Enzyme -0.27875 1.89 48
Macrophage metalloelastase MMP12 Tchem Enzyme 0.00000 382
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.32178 220.1 155
Myeloblastin PRTN3 Tchem Enzyme -3.41745 2809.9 300