Development Level

Tbio 888 | 10,625
Tdark 764 | 7,003
Tchem 100 | 1,890
Tclin 32 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 52 | 633
preweaning lethality, incomple... 31 | 260
decreased body weight 23 | 174
decreased total body fat amoun... 21 | 186
abnormal behavior 17 | 226
decreased lean body mass 17 | 195
embryonic lethality prior to t... 15 | 187
decreased bone mineral density 12 | 126
abnormal retina morphology 11 | 100
decreased circulating glucose ... 11 | 121
hypoactivity 11 | 89
increased bone mineral content 11 | 92
short tibia 11 | 82
abnormal embryo size 10 | 112
decreased body length 10 | 108
decreased grip strength 10 | 123
embryonic lethality prior to o... 10 | 148
hyperactivity 10 | 108
increased or absent threshold ... 10 | 128
increased sacral vertebrae num... 9 | 62
decreased bone mineral content 8 | 157
increased lean body mass 8 | 107
prenatal lethality prior to he... 8 | 64
abnormal bone structure 7 | 131
decreased circulating HDL chol... 7 | 77
decreased circulating choleste... 7 | 85
decreased circulating serum al... 7 | 79
decreased hemoglobin content 7 | 53
increased circulating alkaline... 7 | 119
abnormal bone mineralization 6 | 55
abnormal spleen morphology 6 | 36
decreased caudal vertebrae num... 6 | 49
decreased lumbar vertebrae num... 6 | 62
enlarged heart 6 | 111
increased circulating choleste... 6 | 53
increased monocyte cell number 6 | 27
male infertility 6 | 62
abnormal coat/hair pigmentatio... 5 | 54
abnormal eye morphology 5 | 38
abnormal lens morphology 5 | 73
abnormal retinal pigmentation 5 | 61
decreased circulating LDL chol... 5 | 37
decreased circulating insulin ... 5 | 75
decreased circulating total pr... 5 | 41
decreased circulating triglyce... 5 | 83
decreased heart weight 5 | 44
decreased prepulse inhibition 5 | 52
hydrops fetalis 5 | 22
increased circulating HDL chol... 5 | 63
increased circulating triglyce... 5 | 24
increased mean corpuscular hem... 5 | 93
increased mean corpuscular vol... 5 | 91
abnormal behavioral response t... 4 | 52
abnormal cornea morphology 4 | 24
abnormal heart morphology 4 | 51
abnormal sleep behavior 4 | 63
decreased Ly6C low monocyte nu... 4 | 23
decreased circulating alanine ... 4 | 53
decreased circulating free fat... 4 | 39
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular hem... 4 | 34
decreased mean corpuscular vol... 4 | 50
female infertility 4 | 34
increased body length 4 | 20
increased bone mineral density 4 | 52
increased circulating creatini... 4 | 29
increased circulating iron lev... 4 | 25
increased circulating sodium l... 4 | 71
increased exploration in new e... 4 | 56
increased fasted circulating g... 4 | 68
increased hematocrit 4 | 36
straub tail 4 | 26
abnormal coping response 3 | 12
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal kidney morphology 3 | 30
abnormal locomotor activation 3 | 26
abnormal neural tube closure 3 | 37
abnormal retinal blood vessel ... 3 | 18
abnormal startle reflex 3 | 14
abnormal testis morphology 3 | 30
decreased circulating chloride... 3 | 32
decreased circulating creatini... 3 | 31
decreased circulating iron lev... 3 | 25
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased rib number 3 | 59
decreased total retina thickne... 3 | 20
enlarged spleen 3 | 26
improved glucose tolerance 3 | 56
increased NK cell number 3 | 19
increased circulating calcium ... 3 | 32
increased grip strength 3 | 83
increased heart rate 3 | 17
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
limb grasping 3 | 35
persistence of hyaloid vascula... 3 | 22
small testis 3 | 37
thrombocytopenia 3 | 46

Disease

osteosarcoma 892 | 7,933
ovarian cancer 807 | 8,484
medulloblastoma, large-cell 572 | 6,234
psoriasis 514 | 6,685
glioblastoma 482 | 5,572
atypical teratoid / rhabdoid tumor 413 | 4,369
lung cancer 375 | 4,466
primitive neuroectodermal tumor 322 | 3,031
malignant mesothelioma 294 | 3,162
Carcinoma 281 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 266 | 3,289
oligodendroglioma 259 | 2,849
group 4 medulloblastoma 256 | 1,875
group 3 medulloblastoma 252 | 2,254
Breast cancer 251 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 250 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 244 | 2,956
ependymoma 238 | 2,514
pediatric high grade glioma 200 | 2,712
subependymal giant cell astrocytoma 199 | 2,287
pilocytic astrocytoma 196 | 3,086
invasive ductal carcinoma 194 | 2,950
Cancer 190 | 2,346
Pick disease 189 | 1,893
astrocytic glioma 185 | 2,241
adult high grade glioma 181 | 2,148
lung carcinoma 174 | 2,844
non-small cell lung cancer 167 | 2,798
pancreatic cancer 161 | 2,300
astrocytoma 153 | 1,493
lung adenocarcinoma 149 | 2,713
pituitary cancer 143 | 1,972
interstitial cystitis 139 | 2,299
medulloblastoma 137 | 1,524
juvenile dermatomyositis 135 | 1,189
sonic hedgehog group medulloblastoma 133 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 127 | 1,795
spina bifida 127 | 1,064
ulcerative colitis 127 | 2,087
adrenocortical carcinoma 126 | 1,427
tuberculosis 120 | 1,557
Rheumatoid Arthritis 117 | 1,160
breast carcinoma 108 | 1,614
acute quadriplegic myopathy 104 | 1,157
ductal carcinoma in situ 104 | 1,745
posterior fossa group B ependymoma 102 | 1,530
tuberculosis and treatment for 6 months 102 | 686
posterior fossa group A ependymoma 99 | 1,511
cystic fibrosis 95 | 1,665
primary pancreatic ductal adenocarcinoma 94 | 1,271
Multiple myeloma 91 | 1,327
acute myeloid leukemia 90 | 780
atypical teratoid/rhabdoid tumor 87 | 1,095
colon cancer 82 | 1,475
dermatomyositis 80 | 933
diabetes mellitus 79 | 1,663
non primary Sjogren syndrome sicca 76 | 840
Intellectual disability 68 | 573
hepatocellular carcinoma 67 | 532
progressive supranuclear palsy 67 | 674
cutaneous lupus erythematosus 64 | 1,056
primary Sjogren syndrome 64 | 789
Atopic dermatitis 59 | 944
gastric cancer 58 | 430
aldosterone-producing adenoma 56 | 664
nasopharyngeal carcinoma 53 | 1,056
active Crohn's disease 51 | 918
gastric carcinoma 50 | 832
Amyotrophic Lateral Sclerosis 48 | 431
Waldenstrons macroglobulinemia 47 | 765
pancreatic carcinoma 45 | 567
Mammary Neoplasms 44 | 410
esophageal adenocarcinoma 42 | 737
Alzheimer's disease 41 | 644
chronic rhinosinusitis 38 | 512
Prostatic Neoplasms 37 | 471
active ulcerative colitis 37 | 477
Schizophrenia 35 | 501
facioscapulohumeral dystrophy 35 | 286
glioblastoma multiforme 35 | 347
autosomal dominant Emery-Dreifuss muscular dystrophy 34 | 499
sarcoidosis 34 | 358
Acquired metabolic disease 33 | 267
Down syndrome 33 | 548
Endometriosis 33 | 535
Multiple Sclerosis 32 | 498
mucosa-associated lymphoid tissue lymphoma 31 | 480
Duchenne muscular dystrophy 28 | 602
Stomach Neoplasms 28 | 282
Crohn's disease 27 | 304
fibroadenoma 26 | 557
inflammatory breast cancer 26 | 404
Neurodegenerative disease 24 | 383
Obesity 24 | 616
hereditary spastic paraplegia 24 | 313
Gaucher disease type 1 23 | 171
interstitial lung disease 23 | 291
Bipolar Disorder 22 | 266
Polycystic Ovary Syndrome 22 | 332
Prostate cancer 22 | 172

Tissue

Nervous System 1,724 | 18,561
Female tissues 1,714 | 18,647
Endocrine System 1,711 | 18,512
Urinary Tract 1,711 | 18,444
Digestive Tract 1,709 | 18,473
Liver and Pancreas 1,704 | 18,136
Cardiovascular System 1,703 | 17,958
Blood and immune system 1,702 | 17,995
Male tissues 1,702 | 17,969
Skin and soft tissues 1,688 | 18,115
Respiratory system 1,670 | 17,484

Target Family

Transcription Factor 710 | 1,400
Non-IDG 573 | 11,971
Enzyme 283 | 4,146
Epigenetic 108 | 242
Nuclear Receptor 46 | 48
Kinase 35 | 634
TF/Epigenetic 28 | 38
Transporter 1 | 473

UniProt Keyword

Zinc-finger 1,784 | 1,784
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Zinc finger CCHC domain-containing protein 16 ZCCHC16 Tdark Non-IDG -1.29964 20.8 7