Development Level

Tbio 959 | 11,651
Tdark 717 | 6,593
Tchem 77 | 1,388
Tclin 32 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 84 | 979
preweaning lethality, incomple... 53 | 499
decreased total body fat amoun... 24 | 207
embryonic lethality prior to t... 24 | 278
decreased body weight 22 | 161
abnormal behavior 21 | 298
abnormal embryo size 21 | 220
increased lean body mass 21 | 172
abnormal bone structure 18 | 187
embryonic lethality prior to o... 18 | 239
decreased bone mineral density 16 | 126
abnormal heart morphology 15 | 162
decreased vertical activity 15 | 208
enlarged heart 15 | 210
male infertility 15 | 123
hypoactivity 14 | 132
decreased circulating glucose ... 13 | 126
hyperactivity 13 | 148
decreased lean body mass 12 | 135
increased startle reflex 12 | 112
short tibia 12 | 97
increased bone mineral content 11 | 108
prenatal lethality prior to he... 11 | 87
abnormal seminal vesicle morph... 10 | 114
decreased body length 10 | 101
embryonic growth retardation 10 | 106
female infertility 10 | 60
increased circulating HDL chol... 10 | 80
increased total body fat amoun... 10 | 134
abnormal kidney morphology 9 | 65
decreased bone mineral content 9 | 151
decreased circulating serum al... 9 | 82
impaired glucose tolerance 9 | 75
abnormal spleen morphology 8 | 55
decreased circulating insulin ... 8 | 76
decreased prepulse inhibition 8 | 82
increased bone mineral density 8 | 72
cataract 7 | 92
decreased circulating choleste... 7 | 93
decreased circulating total pr... 7 | 49
decreased grip strength 7 | 116
decreased hemoglobin content 7 | 68
decreased mean corpuscular hem... 7 | 50
edema 7 | 59
increased or absent threshold ... 7 | 101
abnormal behavioral response t... 6 | 66
abnormal eye morphology 6 | 68
abnormal lens morphology 6 | 81
abnormal testis morphology 6 | 43
decreased caudal vertebrae num... 6 | 53
decreased circulating alanine ... 6 | 47
decreased circulating triglyce... 6 | 79
decreased heart left ventricle... 6 | 28
decreased mean corpuscular vol... 6 | 79
increased circulating alkaline... 6 | 122
increased fasted circulating g... 6 | 76
increased mean corpuscular hem... 6 | 96
small testis 6 | 58
thin ventricular wall 6 | 24
abnormal coat-hair pigmentatio... 5 | 64
abnormal neural tube closure 5 | 46
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
decreased circulating HDL chol... 5 | 68
decreased circulating LDL chol... 5 | 38
decreased leukocyte cell numbe... 5 | 73
decreased lymphocyte cell numb... 5 | 83
enlarged spleen 5 | 41
improved glucose tolerance 5 | 79
increased body length 5 | 32
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased erythrocyte cell num... 5 | 39
increased hematocrit 5 | 46
increased monocyte cell number 5 | 63
small superior vagus ganglion 5 | 74
abnormal bone mineralization 4 | 38
abnormal cornea morphology 4 | 31
abnormal craniofacial morpholo... 4 | 33
abnormal gait 4 | 69
abnormal midbrain development 4 | 20
abnormal retinal blood vessel ... 4 | 26
abnormal skin morphology 4 | 50
anophthalmia 4 | 33
decreased blood urea nitrogen ... 4 | 51
decreased circulating alkaline... 4 | 46
decreased circulating aspartat... 4 | 34
decreased circulating iron lev... 4 | 32
decreased fasted circulating g... 4 | 65
decreased hematocrit 4 | 46
decreased mean platelet volume 4 | 25
decreased neutrophil cell numb... 4 | 42
hemorrhage 4 | 23
hydrometra 4 | 53
increased circulating creatini... 4 | 38
increased circulating triglyce... 4 | 42
increased grip strength 4 | 41
increased heart weight 4 | 62
increased hemoglobin content 4 | 45
increased mean corpuscular vol... 4 | 92

Disease

Carcinoma 1,311 | 11,493
osteosarcoma 892 | 7,950
ovarian cancer 810 | 8,520
medulloblastoma, large-cell 572 | 6,241
psoriasis 513 | 6,694
glioblastoma 507 | 5,792
atypical teratoid / rhabdoid tumor 463 | 5,112
group 3 medulloblastoma 448 | 4,104
lung cancer 411 | 4,740
ependymoma 370 | 4,679
Kidney cancer 348 | 2,613
primitive neuroectodermal tumor 322 | 3,035
adult high grade glioma 299 | 3,801
malignant mesothelioma 299 | 3,232
Breast cancer 289 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 266 | 3,291
oligodendroglioma 259 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 250 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 244 | 2,955
group 4 medulloblastoma 221 | 1,855
astrocytic glioma 218 | 2,597
Cancer 208 | 2,499
subependymal giant cell astrocytoma 199 | 2,287
Astrocytoma, Pilocytic 196 | 3,081
invasive ductal carcinoma 194 | 2,951
Pick disease 189 | 1,894
pancreatic cancer 175 | 2,398
lung carcinoma 174 | 2,843
non-small cell lung cancer 168 | 2,890
tuberculosis 161 | 2,010
lung adenocarcinoma 149 | 2,716
pituitary cancer 143 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 141 | 1,962
interstitial cystitis 139 | 2,312
juvenile dermatomyositis 135 | 1,187
adrenocortical carcinoma 126 | 1,428
spina bifida 126 | 1,074
astrocytoma 120 | 1,146
Rheumatoid arthritis 117 | 1,191
breast carcinoma 111 | 1,638
ulcerative colitis 111 | 1,819
Intellectual disability 104 | 1,016
acute quadriplegic myopathy 104 | 1,158
ductal carcinoma in situ 104 | 1,745
cystic fibrosis 96 | 1,696
Multiple myeloma 92 | 1,332
acute myeloid leukemia 91 | 783
diabetes mellitus 83 | 1,728
colon cancer 82 | 1,478
dermatomyositis 82 | 966
pediatric high grade glioma 82 | 1,064
primary pancreatic ductal adenocarcinoma 80 | 1,109
non primary Sjogren syndrome sicca 79 | 891
Schizophrenia 71 | 1,160
Liver cancer 69 | 604
hepatocellular carcinoma 67 | 547
progressive supranuclear palsy 67 | 676
tuberculosis and treatment for 6 months 66 | 409
cutaneous lupus erythematosus 64 | 1,057
primary Sjogren syndrome 61 | 735
Atopic dermatitis 60 | 952
Autosomal recessive predisposition 60 | 1,442
medulloblastoma 60 | 720
Dull intelligence 59 | 645
Low intelligence 59 | 645
Mental Retardation 59 | 645
Mental deficiency 59 | 645
Poor school performance 59 | 645
gastric cancer 59 | 459
aldosterone-producing adenoma 56 | 665
active ulcerative colitis 55 | 764
nasopharyngeal carcinoma 52 | 1,058
Short stature 51 | 531
active Crohn's disease 51 | 922
sonic hedgehog group medulloblastoma 50 | 467
Amyotrophic lateral sclerosis 49 | 451
gastric carcinoma 49 | 807
Cognitive delay 47 | 608
Global developmental delay 47 | 608
Mental and motor retardation 47 | 608
Waldenstrons macroglobulinemia 47 | 765
Bipolar Disorder 45 | 666
Breast Neoplasms 45 | 445
Mammary Neoplasms 45 | 425
Muscle hypotonia 45 | 571
pancreatic carcinoma 45 | 562
Melanoma 43 | 711
Prostatic Neoplasms 42 | 495
esophageal adenocarcinoma 42 | 737
Alzheimer's disease 41 | 658
Acquired metabolic disease 39 | 336
Epilepsy 39 | 792
chronic rhinosinusitis 38 | 512
Obesity 37 | 678
atypical teratoid/rhabdoid tumor 37 | 357
Cryptorchidism 36 | 296
Endometrial cancer 35 | 311
Endometriosis 35 | 540
Multiple Sclerosis 35 | 540
posterior fossa group B ependymoma 35 | 416

Tissue

Endocrine System 1,714 | 18,159
Female tissues 1,668 | 17,400
Male tissues 1,667 | 17,142
Skin and soft tissues 1,663 | 17,230
Digestive Tract 1,658 | 17,369
Nervous System 1,654 | 16,725
Blood and immune system 1,643 | 16,909
Liver and Pancreas 1,640 | 16,750
Urinary Tract 1,635 | 16,678
Respiratory system 1,626 | 16,393
Cardiovascular System 1,569 | 15,192

Target Family

Transcription Factor 710 | 1,400
Non-IDG 574 | 12,091
Enzyme 283 | 4,145
Epigenetic 108 | 242
Nuclear Receptor 46 | 48
Kinase 35 | 634
TF/Epigenetic 28 | 38
Transporter 1 | 473

UniProt Keyword

Zinc-finger 1,785 | 1,785
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Putative tripartite motif-containing protein 49B TRIM49B Tdark Non-IDG 0.00000 0.50 3
Zinc finger CCHC domain-containing protein 9 ZCCHC9 Tdark Non-IDG 0.48 0.71 31
Transcriptional repressor scratch 2 SCRT2 Tdark Transcription Factor 0.22 1.09 25
Zinc finger homeobox protein 2 ZFHX2 Tdark Transcription Factor -0.50515 3.13 28
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123