Development Level

Tbio 144 | 11,445
Tchem 30 | 1,598
Tdark 7 | 6,588
Tclin 2 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased vertical activity 8 | 208
decreased total body fat amoun... 6 | 207
preweaning lethality, incomple... 6 | 499
abnormal heart morphology 5 | 162
enlarged heart 5 | 210
increased startle reflex 5 | 112
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
decreased body weight 4 | 161
embryonic lethality prior to t... 4 | 278
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
abnormal kidney morphology 3 | 65
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
improved glucose tolerance 3 | 79
increased or absent threshold ... 3 | 101
prenatal lethality prior to he... 3 | 87
abnormal bone mineralization 2 | 38
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
edema 2 | 59
hydrometra 2 | 53
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytosis 2 | 27
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal eyelid morphology 1 | 7
abnormal head morphology 1 | 10
abnormal head size 1 | 6
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
cataract 1 | 92
cleft palate 1 | 8
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
enlarged spleen 1 | 41
facial cleft 1 | 3
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating glycerol... 1 | 9
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
prenatal lethality 1 | 28
prolonged PQ interval 1 | 5
small adrenal glands 1 | 16
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 137 | 11,493
ovarian cancer 97 | 8,520
osteosarcoma 91 | 7,950
psoriasis 76 | 6,694
medulloblastoma, large-cell 72 | 6,241
glioblastoma 68 | 5,792
atypical teratoid / rhabdoid tumor 64 | 5,112
Cancer 60 | 2,499
ependymoma 58 | 4,679
Breast cancer 54 | 3,578
lung cancer 54 | 4,740
group 3 medulloblastoma 50 | 4,104
malignant mesothelioma 43 | 3,232
Kidney cancer 42 | 2,613
adult high grade glioma 41 | 3,801
interstitial cystitis 41 | 2,312
primitive neuroectodermal tumor 40 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
non-small cell lung cancer 39 | 2,890
invasive ductal carcinoma 38 | 2,951
breast carcinoma 37 | 1,638
Astrocytoma, Pilocytic 35 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
oligodendroglioma 34 | 2,850
astrocytic glioma 32 | 2,597
lung adenocarcinoma 31 | 2,716
lung carcinoma 31 | 2,843
cystic fibrosis 28 | 1,696
subependymal giant cell astrocytoma 27 | 2,287
pancreatic cancer 25 | 2,398
pituitary cancer 23 | 1,972
Schizophrenia 22 | 1,160
ductal carcinoma in situ 22 | 1,745
ulcerative colitis 22 | 1,819
adrenocortical carcinoma 21 | 1,428
group 4 medulloblastoma 21 | 1,855
Pick disease 19 | 1,894
primary pancreatic ductal adenocarcinoma 18 | 1,109
colon cancer 17 | 1,478
cutaneous lupus erythematosus 17 | 1,057
Bipolar Disorder 16 | 666
Breast Neoplasms 16 | 445
Osteoporosis 16 | 363
juvenile dermatomyositis 16 | 1,187
medulloblastoma 16 | 720
tuberculosis 16 | 2,010
Rheumatoid arthritis 15 | 1,191
Autosomal recessive predisposition 14 | 1,442
Colorectal Neoplasms 14 | 243
Intellectual disability 14 | 1,016
Mammary Neoplasms 14 | 425
astrocytoma 14 | 1,146
diabetes mellitus 14 | 1,728
non primary Sjogren syndrome sicca 14 | 891
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Obesity 13 | 678
acute quadriplegic myopathy 13 | 1,158
dermatomyositis 13 | 966
Alzheimer's disease 12 | 658
acute myeloid leukemia 12 | 783
esophageal adenocarcinoma 12 | 737
pediatric high grade glioma 12 | 1,064
Duchenne muscular dystrophy 10 | 601
fibroadenoma 10 | 559
Cognitive delay 9 | 608
Crohn's disease 9 | 321
Global developmental delay 9 | 608
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Mental and motor retardation 9 | 608
Micrognathism 9 | 275
Orbital separation excessive 9 | 244
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
spina bifida 9 | 1,074
Atopic dermatitis 8 | 952
Liver cancer 8 | 604
Multiple myeloma 8 | 1,332
Robinow syndrome 8 | 11
Short stature 8 | 531
Stomach Neoplasms 8 | 300
gastric carcinoma 8 | 807
posterior fossa group A ependymoma 8 | 468
Amyotrophic lateral sclerosis 7 | 451
Autistic Disorder 7 | 364
Colonic Neoplasms 7 | 142
Depressive disorder 7 | 409
Dull intelligence 7 | 645
Frontal bossing 7 | 157
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
aldosterone-producing adenoma 7 | 665
atypical teratoid/rhabdoid tumor 7 | 357
nasopharyngeal carcinoma 7 | 1,058
tuberculosis and treatment for 6 months 7 | 409

Tissue

Endocrine System 180 | 18,159
Nervous System 180 | 16,725
Digestive Tract 179 | 17,369
Female tissues 179 | 17,400
Skin and soft tissues 178 | 17,230
Blood and immune system 177 | 16,909
Male tissues 177 | 17,142
Urinary Tract 174 | 16,678
Liver and Pancreas 173 | 16,750
Respiratory system 169 | 16,393
Cardiovascular System 162 | 15,192

Target Family

Non-IDG 106 | 12,091
Kinase 24 | 634
Enzyme 21 | 4,145
Transcription Factor 15 | 1,400
GPCR 12 | 408
Epigenetic 4 | 242
Transporter 1 | 473

UniProt Keyword

Wnt signaling pathway 183 | 183
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Leucine-rich repeat flightless-interacting protein 2 LRRFIP2 Tbio Non-IDG -0.65733 4.88 129
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
R-spondin-4 RSPO4 Tbio Non-IDG -1.45244 28.7 66
Putative segment polarity protein dishevelled homolog DVL1P1 DVL1P1 Tdark Non-IDG -2.11561 188.4 0
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Metalloprotease TIKI2 TRABD2B Tbio Enzyme -0.77815 7.28 4
E3 ubiquitin-protein ligase RNF138 RNF138 Tbio Transcription Factor -1.08996 12.5 148