Development Level

Tbio 143 | 10,625
Tchem 30 | 1,890
Tdark 7 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 9 | 633
decreased lean body mass 6 | 195
preweaning lethality, incomple... 5 | 260
decreased lumbar vertebrae num... 4 | 62
decreased total body fat amoun... 4 | 186
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased startle reflex 3 | 48
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal testis morphology 2 | 30
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
enlarged heart 2 | 111
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
small testis 2 | 37
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal facial morphology 1 | 9
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 4
abnormal head size 1 | 1
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal pelvic girdle bone mo... 1 | 11
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
abnormal vibrissa morphology 1 | 17
anophthalmia 1 | 20
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
facial cleft 1 | 3
female infertility 1 | 34
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating glycerol... 1 | 11
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased rib number 1 | 41
increased startle reflex 1 | 38
microphthalmia 1 | 15
mydriasis 1 | 9
prenatal lethality 1 | 16
small adrenal glands 1 | 15
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 97 | 8,484
osteosarcoma 90 | 7,933
psoriasis 76 | 6,685
medulloblastoma, large-cell 72 | 6,234
glioblastoma 65 | 5,572
atypical teratoid / rhabdoid tumor 58 | 4,369
Cancer 56 | 2,346
lung cancer 52 | 4,466
Breast cancer 47 | 3,094
interstitial cystitis 41 | 2,299
malignant mesothelioma 41 | 3,162
primitive neuroectodermal tumor 40 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
invasive ductal carcinoma 38 | 2,950
non-small cell lung cancer 37 | 2,798
breast carcinoma 36 | 1,614
ependymoma 35 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,289
pilocytic astrocytoma 35 | 3,086
oligodendroglioma 34 | 2,849
lung carcinoma 31 | 2,844
Carcinoma 30 | 2,147
lung adenocarcinoma 30 | 2,713
pediatric high grade glioma 29 | 2,712
cystic fibrosis 28 | 1,665
group 3 medulloblastoma 28 | 2,254
sonic hedgehog group medulloblastoma 28 | 1,482
subependymal giant cell astrocytoma 27 | 2,287
astrocytic glioma 26 | 2,241
adult high grade glioma 24 | 2,148
group 4 medulloblastoma 23 | 1,875
pancreatic cancer 23 | 2,300
pituitary cancer 23 | 1,972
ulcerative colitis 23 | 2,087
ductal carcinoma in situ 22 | 1,745
adrenocortical carcinoma 21 | 1,427
primary pancreatic ductal adenocarcinoma 21 | 1,271
Pick disease 19 | 1,893
astrocytoma 19 | 1,493
posterior fossa group A ependymoma 18 | 1,511
colon cancer 17 | 1,475
cutaneous lupus erythematosus 17 | 1,056
juvenile dermatomyositis 16 | 1,189
posterior fossa group B ependymoma 16 | 1,530
Rheumatoid Arthritis 15 | 1,160
Colorectal Neoplasms 14 | 217
Mammary Neoplasms 14 | 410
Osteoporosis 14 | 257
diabetes mellitus 14 | 1,663
medulloblastoma 14 | 1,524
non primary Sjogren syndrome sicca 14 | 840
acute quadriplegic myopathy 13 | 1,157
atypical teratoid/rhabdoid tumor 13 | 1,095
dermatomyositis 13 | 933
tuberculosis 13 | 1,557
acute myeloid leukemia 12 | 780
esophageal adenocarcinoma 12 | 737
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Alzheimer's disease 10 | 644
Duchenne muscular dystrophy 10 | 602
fibroadenoma 10 | 557
Crohn's disease 9 | 304
Intellectual disability 9 | 573
non-inflammatory breast cancer 9 | 208
spina bifida 9 | 1,064
Atopic dermatitis 8 | 944
Multiple myeloma 8 | 1,327
Obesity 8 | 616
Robinow syndrome 8 | 12
Schizophrenia 8 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
gastric carcinoma 8 | 832
tuberculosis and treatment for 6 months 8 | 686
Amyotrophic Lateral Sclerosis 7 | 431
Colonic Neoplasms 7 | 126
aldosterone-producing adenoma 7 | 664
nasopharyngeal carcinoma 7 | 1,056
Autistic Disorder 6 | 320
Bipolar Disorder 6 | 266
Cleft palate 6 | 125
Kidney disease 6 | 396
Stomach Neoplasms 6 | 282
Syndactyly 6 | 56
Waldenstrons macroglobulinemia 6 | 765
active Crohn's disease 6 | 918
primary Sjogren syndrome 6 | 789
sarcoidosis 6 | 358
Adenoma 5 | 165
Liver carcinoma 5 | 217
Parkinson's disease 5 | 364
Peripheral Neuropathy 5 | 303
Type 2 diabetes mellitus 5 | 189
active ulcerative colitis 5 | 477
chronic rhinosinusitis 5 | 512
glioblastoma multiforme 5 | 347
limb girdle muscular dystrophy 2A 5 | 156
pancreatic carcinoma 5 | 567
urothelial carcinoma 5 | 318
Prostatic Neoplasms 4 | 471

Tissue

Digestive Tract 181 | 18,473
Endocrine System 181 | 18,512
Female tissues 181 | 18,647
Male tissues 181 | 17,969
Nervous System 181 | 18,561
Skin and soft tissues 181 | 18,115
Urinary Tract 181 | 18,444
Blood and immune system 180 | 17,995
Liver and Pancreas 180 | 18,136
Respiratory system 180 | 17,484
Cardiovascular System 179 | 17,958

Target Family

Non-IDG 105 | 11,971
Kinase 24 | 634
Enzyme 21 | 4,146
Transcription Factor 15 | 1,400
GPCR 12 | 406
Epigenetic 4 | 242
Transporter 1 | 473

UniProt Keyword

Wnt signaling pathway 182 | 182
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Frizzled-7 FZD7 Tbio GPCR -1.70812 55.9 303
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Palmitoleoyl-protein carboxylesterase NOTUM NOTUM Tchem Enzyme -2.17902 149.5 98
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722
Low-density lipoprotein receptor-related protein 4 LRP4 Tbio Non-IDG -1.98324 105.2 178
Cyclin-Y CCNY Tbio Non-IDG -1.41033 27.8 102
Kelch-like protein 12 KLHL12 Tbio Non-IDG -0.95785 9.67 180
Kremen protein 2 KREMEN2 Tbio Non-IDG -0.72771 5.50 84
Frizzled-4 FZD4 Tbio GPCR -1.97561 92.5 273