Development Level

Tclin 67 | 613
Tbio 48 | 11,445
Tchem 27 | 1,598
Tdark 9 | 6,588

Collection

Ion Channel: IDG Consortium (T... 49 | 99

IMPC Phenotype

abnormal behavior 9 | 298
hyperactivity 6 | 148
preweaning lethality, complete... 6 | 979
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased mean corpuscular vol... 3 | 92
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal heart shape 1 | 5
abnormal locomotor behavior 1 | 24
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac stroke volum... 1 | 6
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating chloride... 1 | 41
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased vertical activity 1 | 24
kyphosis 1 | 5
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened QT interval 1 | 4
shortened ST segment 1 | 10
small heart 1 | 10
small liver 1 | 8
tremors 1 | 39

Disease

Carcinoma 117 | 11,493
medulloblastoma, large-cell 71 | 6,241
ependymoma 67 | 4,679
glioblastoma 66 | 5,792
atypical teratoid / rhabdoid tumor 65 | 5,112
adult high grade glioma 64 | 3,801
Astrocytoma, Pilocytic 55 | 3,081
osteosarcoma 55 | 7,950
psoriasis 54 | 6,694
oligodendroglioma 50 | 2,850
primitive neuroectodermal tumor 49 | 3,035
Kidney cancer 48 | 2,613
group 3 medulloblastoma 47 | 4,104
ovarian cancer 46 | 8,520
Multiple Sclerosis 43 | 540
lung carcinoma 42 | 2,843
Epilepsy 41 | 792
Eaton-Lambert syndrome 40 | 40
lung cancer 40 | 4,740
astrocytic glioma 37 | 2,597
subependymal giant cell astrocytoma 32 | 2,287
malignant mesothelioma 29 | 3,232
Breast cancer 28 | 3,578
Atrial Fibrillation 24 | 124
pituitary cancer 24 | 1,972
Pick disease 23 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Intellectual disability 21 | 1,016
lung adenocarcinoma 21 | 2,716
Long QT syndrome 20 | 39
invasive ductal carcinoma 20 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Liver cancer 18 | 604
Seizures 18 | 596
Brugada syndrome 17 | 29
Schizophrenia 17 | 1,160
Skin cancer 16 | 469
cystic fibrosis 16 | 1,696
interstitial cystitis 16 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Autosomal recessive predisposition 15 | 1,442
Melanoma 15 | 711
Muscle hypotonia 15 | 571
non-small cell lung cancer 15 | 2,890
Bipolar Disorder 14 | 666
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
pancreatic cancer 14 | 2,398
Cerebellar Ataxia 13 | 304
Heart disease 13 | 306
breast carcinoma 13 | 1,638
colon cancer 13 | 1,478
ductal carcinoma in situ 13 | 1,745
Brugada Syndrome (disorder) 11 | 15
Hypokalemia 11 | 52
Life-Threatening Ventricular Tachycardia 11 | 15
Ventricular arrhythmia 11 | 27
adrenocortical carcinoma 11 | 1,428
group 4 medulloblastoma 11 | 1,855
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 10 | 21
Cough 10 | 23
Dull intelligence 10 | 645
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Episodic ataxia 10 | 22
Familial atrial fibrillation 10 | 23
Infantile onset 10 | 238
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Poor school performance 10 | 645
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Type 2 diabetes mellitus 10 | 272
Urinary Tract Irritation 10 | 24
active Crohn's disease 10 | 922
tuberculosis 10 | 2,010
ulcerative colitis 10 | 1,819
Endometrial cancer 9 | 311
Hypertension 9 | 396
Postherpetic neuralgia 9 | 11
Status Epilepticus 9 | 98
Tremor 9 | 113
Ventricular Fibrillation 9 | 17
astrocytoma 9 | 1,146

Tissue

Endocrine System 149 | 18,159
Nervous System 138 | 16,725
Digestive Tract 136 | 17,369
Female tissues 134 | 17,400
Male tissues 132 | 17,142
Skin and soft tissues 129 | 17,230
Blood and immune system 125 | 16,909
Liver and Pancreas 124 | 16,750
Urinary Tract 122 | 16,678
Respiratory system 118 | 16,393
Cardiovascular System 98 | 15,192

Target Family

Ion Channel 149 | 344
Enzyme 1 | 4,145
Non-IDG 1 | 12,091

UniProt Keyword

Voltage-gated channel 151 | 151
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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