Development Level

Tbio 534 | 11,651
Tdark 125 | 6,593
Tchem 23 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 50 | 979
preweaning lethality, incomple... 30 | 499
abnormal behavior 23 | 298
decreased bone mineral content 18 | 151
decreased lean body mass 18 | 135
male infertility 17 | 123
abnormal bone structure 15 | 187
decreased body weight 15 | 161
decreased bone mineral density 13 | 126
hypoactivity 13 | 132
embryonic lethality prior to t... 12 | 278
increased total body fat amoun... 12 | 134
decreased body length 11 | 101
enlarged heart 11 | 210
female infertility 10 | 60
increased lean body mass 10 | 172
increased mean corpuscular vol... 10 | 92
abnormal embryo size 9 | 220
abnormal heart morphology 9 | 162
decreased grip strength 9 | 116
decreased total body fat amoun... 9 | 207
decreased vertical activity 8 | 208
increased circulating alkaline... 8 | 122
increased mean platelet volume 8 | 45
increased or absent threshold ... 8 | 101
decreased hemoglobin content 7 | 68
decreased leukocyte cell numbe... 7 | 73
decreased mean corpuscular hem... 7 | 50
decreased startle reflex 7 | 75
embryonic lethality prior to o... 7 | 239
hyperactivity 7 | 148
increased circulating HDL chol... 7 | 80
increased mean corpuscular hem... 7 | 96
short tibia 7 | 97
abnormal gait 6 | 69
decreased circulating glucose ... 6 | 126
decreased erythrocyte cell num... 6 | 62
decreased neutrophil cell numb... 6 | 42
increased mean corpuscular hem... 6 | 36
thrombocytopenia 6 | 56
corneal opacity 5 | 32
decreased blood urea nitrogen ... 5 | 51
decreased circulating alkaline... 5 | 46
decreased circulating chloride... 5 | 30
decreased circulating creatini... 5 | 39
decreased circulating fructosa... 5 | 30
decreased circulating total pr... 5 | 49
decreased circulating triglyce... 5 | 79
decreased hematocrit 5 | 46
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
decreased red blood cell distr... 5 | 41
enlarged spleen 5 | 41
increased bone mineral content 5 | 108
increased circulating choleste... 5 | 66
increased hematocrit 5 | 46
increased lymphocyte cell numb... 5 | 32
thrombocytosis 5 | 27
abnormal bone mineralization 4 | 38
abnormal coat-hair pigmentatio... 4 | 64
abnormal seminal vesicle morph... 4 | 114
abnormal spleen morphology 4 | 55
decreased basophil cell number 4 | 16
decreased circulating alanine ... 4 | 47
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased heart left ventricle... 4 | 28
decreased lymphocyte cell numb... 4 | 83
decreased mean platelet volume 4 | 25
embryonic growth retardation 4 | 106
increased bone mineral density 4 | 72
increased circulating chloride... 4 | 41
increased circulating creatini... 4 | 38
increased circulating glucose ... 4 | 24
increased circulating phosphat... 4 | 26
increased heart weight 4 | 62
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
increased red blood cell distr... 4 | 34
increased startle reflex 4 | 112
long tibia 4 | 25
prenatal lethality prior to he... 4 | 87
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
abnormal vocalization 3 | 21
anophthalmia 3 | 33
decreased caudal vertebrae num... 3 | 53
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased circulating iron lev... 3 | 32
decreased mean corpuscular hem... 3 | 31
impaired glucose tolerance 3 | 75
increased body length 3 | 32
increased circulating serum al... 3 | 22
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased eosinophil cell numb... 3 | 11
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
thin ventricular wall 3 | 24

Disease

Carcinoma 460 | 11,493
ovarian cancer 397 | 8,520
osteosarcoma 331 | 7,950
medulloblastoma, large-cell 257 | 6,241
glioblastoma 222 | 5,792
atypical teratoid / rhabdoid tumor 210 | 5,112
psoriasis 209 | 6,694
lung cancer 166 | 4,740
ependymoma 157 | 4,679
adult high grade glioma 147 | 3,801
Breast cancer 131 | 3,578
group 3 medulloblastoma 130 | 4,104
malignant mesothelioma 118 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 114 | 3,291
primitive neuroectodermal tumor 111 | 3,035
astrocytic glioma 104 | 2,597
Kidney cancer 98 | 2,613
Cancer 96 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 94 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,955
Astrocytoma, Pilocytic 92 | 3,081
oligodendroglioma 92 | 2,850
subependymal giant cell astrocytoma 92 | 2,287
group 4 medulloblastoma 82 | 1,855
Multiple myeloma 81 | 1,332
Pick disease 80 | 1,894
invasive ductal carcinoma 76 | 2,951
non-small cell lung cancer 74 | 2,890
juvenile dermatomyositis 70 | 1,187
pancreatic cancer 68 | 2,398
tuberculosis 68 | 2,010
Rheumatoid arthritis 61 | 1,191
lung adenocarcinoma 58 | 2,716
spina bifida 58 | 1,074
lung carcinoma 57 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,962
acute quadriplegic myopathy 52 | 1,158
adrenocortical carcinoma 51 | 1,428
pituitary cancer 49 | 1,972
dermatomyositis 44 | 966
ulcerative colitis 44 | 1,819
diabetes mellitus 43 | 1,728
breast carcinoma 42 | 1,638
tuberculosis and treatment for 6 months 40 | 409
interstitial cystitis 38 | 2,312
medulloblastoma 36 | 720
Intellectual disability 35 | 1,016
cystic fibrosis 35 | 1,696
acute myeloid leukemia 32 | 783
astrocytoma 32 | 1,146
active Crohn's disease 31 | 922
primary pancreatic ductal adenocarcinoma 30 | 1,109
progressive supranuclear palsy 30 | 676
Waldenstrons macroglobulinemia 29 | 765
hepatocellular carcinoma 29 | 547
Atopic dermatitis 28 | 952
non primary Sjogren syndrome sicca 28 | 891
Autosomal recessive predisposition 27 | 1,442
ductal carcinoma in situ 26 | 1,745
cutaneous lupus erythematosus 25 | 1,057
pediatric high grade glioma 25 | 1,064
Liver cancer 24 | 604
Parkinson's disease 23 | 392
colon cancer 23 | 1,478
gastric carcinoma 23 | 807
Amyotrophic lateral sclerosis 22 | 451
esophageal adenocarcinoma 22 | 737
primary Sjogren syndrome 22 | 735
active ulcerative colitis 20 | 764
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Multiple Sclerosis 19 | 540
Poor school performance 19 | 645
aldosterone-producing adenoma 19 | 665
Neurodegenerative disease 18 | 414
hereditary spastic paraplegia 18 | 318
nasopharyngeal carcinoma 18 | 1,058
sonic hedgehog group medulloblastoma 18 | 467
Schizophrenia 17 | 1,160
Alzheimer's disease 15 | 658
Duchenne muscular dystrophy 15 | 601
Muscle hypotonia 15 | 571
Short stature 15 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
gastric cancer 15 | 459
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Liver Cirrhosis, Experimental 14 | 769
Melanoma 14 | 711
Mental and motor retardation 14 | 608
pancreatic carcinoma 14 | 562
Autistic Disorder 13 | 364
Endometriosis 13 | 540
Gaucher disease type 1 13 | 180
sarcoidosis 13 | 370
Prostatic Neoplasms 12 | 495
chronic rhinosinusitis 12 | 512
posterior fossa group A ependymoma 12 | 468

Tissue

Endocrine System 665 | 18,159
Female tissues 652 | 17,400
Male tissues 645 | 17,142
Skin and soft tissues 645 | 17,230
Digestive Tract 644 | 17,369
Nervous System 644 | 16,725
Respiratory system 639 | 16,393
Liver and Pancreas 637 | 16,750
Blood and immune system 636 | 16,909
Urinary Tract 636 | 16,678
Cardiovascular System 618 | 15,192

Target Family

Non-IDG 354 | 12,091
Enzyme 301 | 4,145
Epigenetic 15 | 242
Transcription Factor 13 | 1,400
Kinase 1 | 634

UniProt Keyword

Ubl conjugation pathway 684 | 684
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
F-box/LRR-repeat protein 17 FBXL17 Tbio Non-IDG -0.49601 3.17 90
Protein zyg-11 homolog B ZYG11B Tdark Non-IDG -0.49136 2.50 52
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
Ankyrin repeat and SOCS box protein 10 ASB10 Tbio Non-IDG -0.85286 7.76 117
E3 ubiquitin-protein ligase DZIP3 DZIP3 Tbio Enzyme -0.24304 1.68 116