Development Level

Tbio 493 | 10,625
Tdark 136 | 7,003
Tchem 38 | 1,890
Tclin 2 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 36 | 633
decreased lean body mass 26 | 195
preweaning lethality, incomple... 21 | 260
abnormal behavior 20 | 226
decreased grip strength 15 | 123
decreased bone mineral content 14 | 157
decreased body weight 13 | 174
decreased bone mineral density 11 | 126
increased or absent threshold ... 11 | 128
abnormal bone structure 10 | 131
decreased body length 10 | 108
decreased heart weight 10 | 44
decreased total body fat amoun... 9 | 186
increased mean corpuscular vol... 9 | 91
decreased circulating triglyce... 8 | 83
increased circulating alkaline... 8 | 119
abnormal bone mineralization 7 | 55
hyperactivity 7 | 108
male infertility 7 | 62
decreased startle reflex 6 | 48
embryonic lethality prior to t... 6 | 187
hypoactivity 6 | 89
increased lean body mass 6 | 107
increased monocyte cell number 6 | 27
abnormal embryo size 5 | 112
abnormal gait 5 | 51
abnormal retina morphology 5 | 100
decreased B cell number 5 | 30
decreased circulating HDL chol... 5 | 77
decreased circulating fructosa... 5 | 31
decreased circulating glucose ... 5 | 121
decreased circulating serum al... 5 | 79
decreased erythrocyte cell num... 5 | 43
decreased hemoglobin content 5 | 53
decreased leukocyte cell numbe... 5 | 54
increased bone mineral content 5 | 92
increased circulating choleste... 5 | 53
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
thrombocytopenia 5 | 46
abnormal heart left ventricle ... 4 | 20
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular hem... 4 | 34
decreased neutrophil cell numb... 4 | 37
decreased respiratory quotient 4 | 12
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
impaired glucose tolerance 4 | 52
increased NK cell number 4 | 19
increased circulating HDL chol... 4 | 63
increased grip strength 4 | 83
increased mean corpuscular hem... 4 | 93
short tibia 4 | 82
thrombocytosis 4 | 23
abnormal QRS complex 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal retinal pigmentation 3 | 61
abnormal spleen morphology 3 | 36
abnormal vocalization 3 | 21
corneal opacity 3 | 25
decreased CD4-positive, CD25-p... 3 | 24
decreased CD8-positive, alpha-... 3 | 26
decreased circulating LDL chol... 3 | 37
decreased circulating aspartat... 3 | 27
decreased circulating free fat... 3 | 39
decreased circulating total pr... 3 | 41
decreased heart rate 3 | 10
decreased hematocrit 3 | 25
decreased mean corpuscular vol... 3 | 50
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
enlarged spleen 3 | 26
female infertility 3 | 34
improved glucose tolerance 3 | 56
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating glucose ... 3 | 16
increased circulating serum al... 3 | 25
increased effector memory CD4-... 3 | 15
increased mean corpuscular hem... 3 | 25
narrow eye opening 3 | 15
small liver 3 | 8
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal cornea morphology 2 | 24
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
increased circulating bilirubi... 2 | 16
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
small thymus 2 | 11
straub tail 2 | 26
tremors 2 | 34
vertebral fusion 2 | 23

Disease

ovarian cancer 387 | 8,484
osteosarcoma 324 | 7,933
medulloblastoma, large-cell 251 | 6,234
glioblastoma 209 | 5,572
psoriasis 205 | 6,685
atypical teratoid / rhabdoid tumor 187 | 4,369
lung cancer 149 | 4,466
Breast cancer 114 | 3,094
malignant mesothelioma 114 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 110 | 3,289
primitive neuroectodermal tumor 109 | 3,031
ependymoma 100 | 2,514
astrocytic glioma 94 | 2,241
adult high grade glioma 92 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,988
pilocytic astrocytoma 91 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 90 | 2,956
oligodendroglioma 90 | 2,849
subependymal giant cell astrocytoma 89 | 2,287
Cancer 85 | 2,346
Carcinoma 81 | 2,147
Multiple myeloma 80 | 1,327
Pick disease 78 | 1,893
pediatric high grade glioma 76 | 2,712
medulloblastoma 75 | 1,524
invasive ductal carcinoma 74 | 2,950
group 3 medulloblastoma 72 | 2,254
non-small cell lung cancer 72 | 2,798
group 4 medulloblastoma 71 | 1,875
juvenile dermatomyositis 70 | 1,189
pancreatic cancer 61 | 2,300
Rheumatoid Arthritis 60 | 1,160
lung adenocarcinoma 58 | 2,713
lung carcinoma 55 | 2,844
spina bifida 55 | 1,064
tuberculosis and treatment for 6 months 55 | 686
acute quadriplegic myopathy 52 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
adrenocortical carcinoma 50 | 1,427
ulcerative colitis 50 | 2,087
pituitary cancer 46 | 1,972
dermatomyositis 44 | 933
tuberculosis 43 | 1,557
sonic hedgehog group medulloblastoma 42 | 1,482
diabetes mellitus 41 | 1,663
posterior fossa group B ependymoma 41 | 1,530
astrocytoma 39 | 1,493
breast carcinoma 39 | 1,614
interstitial cystitis 37 | 2,299
cystic fibrosis 34 | 1,665
primary pancreatic ductal adenocarcinoma 34 | 1,271
acute myeloid leukemia 32 | 780
posterior fossa group A ependymoma 31 | 1,511
active Crohn's disease 30 | 918
progressive supranuclear palsy 30 | 674
Waldenstrons macroglobulinemia 29 | 765
Atopic dermatitis 28 | 944
Intellectual disability 28 | 573
atypical teratoid/rhabdoid tumor 28 | 1,095
hepatocellular carcinoma 27 | 532
non primary Sjogren syndrome sicca 26 | 840
cutaneous lupus erythematosus 25 | 1,056
ductal carcinoma in situ 25 | 1,745
colon cancer 23 | 1,475
gastric carcinoma 23 | 832
esophageal adenocarcinoma 22 | 737
primary Sjogren syndrome 22 | 789
Amyotrophic Lateral Sclerosis 21 | 431
Parkinson's disease 20 | 364
Neurodegenerative disease 18 | 383
aldosterone-producing adenoma 18 | 664
Multiple Sclerosis 17 | 498
hereditary spastic paraplegia 17 | 313
nasopharyngeal carcinoma 17 | 1,056
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
gastric cancer 15 | 430
Alzheimer's disease 14 | 644
Duchenne muscular dystrophy 14 | 602
IGA Glomerulonephritis 14 | 454
glioblastoma multiforme 14 | 347
pancreatic carcinoma 14 | 567
Gaucher disease type 1 13 | 171
sarcoidosis 13 | 358
Autistic Disorder 12 | 320
Endometriosis 12 | 535
chronic rhinosinusitis 12 | 512
inflammatory breast cancer 12 | 404
Prostatic Neoplasms 11 | 471
Down syndrome 10 | 548
Mammary Neoplasms 10 | 410
non-small cell lung carcinoma 10 | 413
tuberculosis and treatment for 3 months 10 | 327
Angelman syndrome 9 | 38
active ulcerative colitis 9 | 477
interstitial lung disease 9 | 291
Cardiovascular system disease 8 | 194
Liver carcinoma 8 | 217
Male infertility 8 | 170
Neuropathy 8 | 210
non diabetic and post-ischemic heart failure 8 | 200

Tissue

Female tissues 664 | 18,647
Nervous System 664 | 18,561
Blood and immune system 658 | 17,995
Digestive Tract 649 | 18,473
Endocrine System 648 | 18,512
Skin and soft tissues 647 | 18,115
Urinary Tract 647 | 18,444
Male tissues 644 | 17,969
Cardiovascular System 643 | 17,958
Liver and Pancreas 641 | 18,136
Respiratory system 630 | 17,484

Target Family

Non-IDG 340 | 11,971
Enzyme 301 | 4,146
Epigenetic 14 | 242
Transcription Factor 13 | 1,400
Kinase 1 | 634

UniProt Keyword

Ubl conjugation pathway 669 | 669
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Kelch-like protein 10 KLHL10 Tdark Non-IDG -0.62839 4.48 35