Development Level

Tbio 1,737 | 11,445
Tdark 343 | 6,588
Tchem 263 | 1,598
Tclin 96 | 613

Collection

RFA-RM-18-021 13 | 328
Kinase: IDG Consortium (Target... 10 | 125
Kinase: IDG Consortium (Comple... 6 | 37
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 230 | 979
preweaning lethality, incomple... 81 | 499
embryonic lethality prior to t... 52 | 278
abnormal embryo size 50 | 220
embryonic lethality prior to o... 50 | 239
abnormal behavior 45 | 298
decreased body weight 35 | 161
abnormal bone structure 33 | 187
decreased total body fat amoun... 33 | 207
increased lean body mass 32 | 172
increased startle reflex 26 | 112
decreased vertical activity 25 | 208
enlarged heart 25 | 210
hypoactivity 24 | 132
increased total body fat amoun... 24 | 134
abnormal heart morphology 22 | 162
decreased lean body mass 22 | 135
male infertility 22 | 123
decreased prepulse inhibition 20 | 82
increased mean corpuscular vol... 20 | 92
prenatal lethality prior to he... 19 | 87
decreased bone mineral content 18 | 151
decreased bone mineral density 18 | 126
embryonic growth retardation 18 | 106
increased circulating HDL chol... 18 | 80
decreased circulating glucose ... 17 | 126
decreased leukocyte cell numbe... 17 | 73
increased circulating alkaline... 17 | 122
increased fasted circulating g... 17 | 76
increased or absent threshold ... 17 | 101
decreased circulating triglyce... 16 | 79
decreased lymphocyte cell numb... 16 | 83
increased bone mineral density 16 | 72
increased mean corpuscular hem... 16 | 96
cataract 15 | 92
decreased circulating choleste... 15 | 93
hyperactivity 15 | 148
thrombocytopenia 15 | 56
abnormal seminal vesicle morph... 14 | 114
decreased blood urea nitrogen ... 14 | 51
decreased circulating HDL chol... 14 | 68
female infertility 14 | 60
small superior vagus ganglion 14 | 74
abnormal retina morphology 13 | 71
decreased body length 13 | 101
decreased grip strength 13 | 116
decreased mean corpuscular vol... 13 | 79
increased bone mineral content 13 | 108
abnormal neural tube closure 12 | 46
increased grip strength 12 | 41
increased mean platelet volume 12 | 45
increased neutrophil cell numb... 12 | 46
small testis 12 | 58
abnormal gait 11 | 69
decreased circulating serum al... 11 | 82
decreased startle reflex 11 | 75
edema 11 | 59
increased circulating choleste... 11 | 66
increased heart weight 11 | 62
short tibia 11 | 97
abnormal coat-hair pigmentatio... 10 | 64
abnormal lens morphology 10 | 81
decreased circulating alanine ... 10 | 47
decreased hemoglobin content 10 | 68
impaired glucose tolerance 10 | 75
increased monocyte cell number 10 | 63
tremors 10 | 39
abnormal bone mineralization 9 | 38
abnormal craniofacial morpholo... 9 | 33
decreased caudal vertebrae num... 9 | 53
decreased circulating insulin ... 9 | 76
improved glucose tolerance 9 | 79
increased body weight 9 | 25
increased circulating chloride... 9 | 41
abnormal behavioral response t... 8 | 66
abnormal cornea morphology 8 | 31
abnormal eye morphology 8 | 68
abnormal spleen morphology 8 | 55
anophthalmia 8 | 33
corneal opacity 8 | 32
decreased circulating alkaline... 8 | 46
decreased circulating chloride... 8 | 30
decreased erythrocyte cell num... 8 | 62
decreased fasted circulating g... 8 | 65
decreased red blood cell distr... 8 | 41
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 36
thrombocytosis 8 | 27
abnormal kidney morphology 7 | 65
decreased circulating amylase ... 7 | 28
decreased mean corpuscular hem... 7 | 50
decreased neutrophil cell numb... 7 | 42
enlarged spleen 7 | 41
increased body length 7 | 32
increased circulating phosphat... 7 | 26
increased circulating triglyce... 7 | 42
increased prepulse inhibition 7 | 32
prolonged QT interval 7 | 38
decreased circulating free fat... 6 | 31
pallor 6 | 34

Disease

Carcinoma 1,754 | 11,493
ovarian cancer 1,421 | 8,520
osteosarcoma 1,232 | 7,950
psoriasis 963 | 6,694
medulloblastoma, large-cell 950 | 6,241
lung cancer 851 | 4,740
glioblastoma 843 | 5,792
atypical teratoid / rhabdoid tumor 768 | 5,112
group 3 medulloblastoma 735 | 4,104
Cancer 709 | 2,499
ependymoma 641 | 4,679
Breast cancer 635 | 3,578
malignant mesothelioma 539 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 521 | 3,291
adult high grade glioma 491 | 3,801
primitive neuroectodermal tumor 487 | 3,035
Kidney cancer 469 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 453 | 2,989
invasive ductal carcinoma 435 | 2,951
oligodendroglioma 428 | 2,850
non-small cell lung cancer 423 | 2,890
lung adenocarcinoma 416 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 391 | 2,955
astrocytic glioma 379 | 2,597
pancreatic cancer 362 | 2,398
Multiple myeloma 333 | 1,332
Pick disease 332 | 1,894
diabetes mellitus 331 | 1,728
Astrocytoma, Pilocytic 319 | 3,081
subependymal giant cell astrocytoma 316 | 2,287
tuberculosis 304 | 2,010
lung carcinoma 291 | 2,843
breast carcinoma 280 | 1,638
group 4 medulloblastoma 280 | 1,855
Rheumatoid arthritis 276 | 1,191
acute quadriplegic myopathy 276 | 1,158
dermatomyositis 273 | 966
pancreatic ductal adenocarcinoma liver metastasis 264 | 1,962
colon cancer 257 | 1,478
pituitary cancer 257 | 1,972
juvenile dermatomyositis 248 | 1,187
ductal carcinoma in situ 247 | 1,745
astrocytoma 237 | 1,146
adrenocortical carcinoma 235 | 1,428
ulcerative colitis 228 | 1,819
Waldenstrons macroglobulinemia 227 | 765
Intellectual disability 225 | 1,016
interstitial cystitis 215 | 2,312
cystic fibrosis 200 | 1,696
Schizophrenia 188 | 1,160
primary pancreatic ductal adenocarcinoma 174 | 1,109
acute myeloid leukemia 168 | 783
Autosomal recessive predisposition 166 | 1,442
pediatric high grade glioma 165 | 1,064
spina bifida 162 | 1,074
nasopharyngeal carcinoma 154 | 1,058
Dull intelligence 143 | 645
Low intelligence 143 | 645
Mental Retardation 143 | 645
Mental deficiency 143 | 645
Poor school performance 143 | 645
cutaneous lupus erythematosus 141 | 1,057
Breast Neoplasms 135 | 445
progressive supranuclear palsy 131 | 676
Atopic dermatitis 129 | 952
Mammary Neoplasms 129 | 425
Epilepsy 128 | 792
Short stature 127 | 531
Cognitive delay 120 | 608
Global developmental delay 120 | 608
Mental and motor retardation 120 | 608
Alzheimer's disease 119 | 658
Amyotrophic lateral sclerosis 117 | 451
non primary Sjogren syndrome sicca 116 | 891
primary Sjogren syndrome 116 | 735
Bipolar Disorder 106 | 666
hepatocellular carcinoma 106 | 547
Endometriosis 105 | 540
Muscle hypotonia 102 | 571
Obesity 102 | 678
Prostatic Neoplasms 102 | 495
active Crohn's disease 101 | 922
aldosterone-producing adenoma 101 | 665
Seizures 100 | 596
medulloblastoma 100 | 720
Liver cancer 99 | 604
Small head 98 | 374
esophageal adenocarcinoma 96 | 737
gastric cancer 96 | 459
gastric carcinoma 95 | 807
Melanoma 94 | 711
tuberculosis and treatment for 6 months 94 | 409
Multiple Sclerosis 93 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 92 | 510
Arthritis 91 | 290
pancreatic carcinoma 90 | 562
Anemia 86 | 365
Hypersensitivity reaction type II disease 85 | 253
Neurodegenerative disease 85 | 414
Stomach Neoplasms 84 | 300

Tissue

Endocrine System 2,337 | 18,159
Female tissues 2,318 | 17,400
Digestive Tract 2,316 | 17,369
Skin and soft tissues 2,314 | 17,230
Blood and immune system 2,311 | 16,909
Male tissues 2,308 | 17,142
Nervous System 2,302 | 16,725
Liver and Pancreas 2,296 | 16,750
Urinary Tract 2,296 | 16,678
Respiratory system 2,290 | 16,393
Cardiovascular System 2,241 | 15,192

Target Family

Non-IDG 1,308 | 12,091
Transcription Factor 447 | 1,400
Enzyme 357 | 4,145
Kinase 126 | 634
Epigenetic 106 | 242
GPCR 25 | 408
Ion Channel 23 | 344
TF/Epigenetic 21 | 38
Nuclear Receptor 17 | 48
Transporter 9 | 473

UniProt Keyword

Ubl conjugation 2,439 | 2,439
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Zinc finger protein 316 ZNF316 Tdark Non-IDG 0.00000 8