Development Level

Tbio 1,201 | 10,625
Tchem 258 | 1,890
Tdark 195 | 7,003
Tclin 87 | 602

Collection

Kinase: IDG Consortium (Targets) 9 | 125
Kinase: IDG Consortium (Complete/Control) 4 | 37
Ion Channel: IDG Consortium (Targets) 3 | 102
GPCR: IDG Consortium (Complete/Control) 1 | 26
GPCR: IDG Consortium (Targets) 1 | 127

IMPC Phenotype

preweaning lethality, complete... 93 | 633
preweaning lethality, incomple... 39 | 260
decreased body weight 29 | 174
embryonic lethality prior to t... 27 | 187
embryonic lethality prior to o... 25 | 148
abnormal behavior 24 | 226
decreased total body fat amoun... 24 | 186
decreased lean body mass 21 | 195
abnormal embryo size 18 | 112
decreased bone mineral content 18 | 157
increased mean corpuscular vol... 17 | 91
abnormal retina morphology 16 | 100
increased circulating HDL chol... 15 | 63
increased or absent threshold ... 15 | 128
abnormal bone structure 14 | 131
increased grip strength 14 | 83
decreased body length 13 | 108
decreased grip strength 12 | 123
increased lean body mass 12 | 107
prenatal lethality prior to he... 12 | 64
thrombocytopenia 12 | 46
abnormal retinal pigmentation 11 | 61
decreased bone mineral density 10 | 126
decreased circulating HDL chol... 10 | 77
decreased circulating choleste... 10 | 85
decreased circulating glucose ... 10 | 121
hyperactivity 10 | 108
hypoactivity 10 | 89
increased circulating alkaline... 10 | 119
increased fasted circulating g... 10 | 68
increased mean corpuscular hem... 10 | 93
abnormal bone mineralization 9 | 55
abnormal sleep behavior 9 | 63
decreased leukocyte cell numbe... 9 | 54
decreased mean corpuscular vol... 9 | 50
decreased prepulse inhibition 9 | 52
decreased startle reflex 9 | 48
enlarged heart 9 | 111
increased bone mineral content 9 | 92
increased circulating choleste... 9 | 53
decreased caudal vertebrae num... 8 | 49
decreased circulating serum al... 8 | 79
decreased fasted circulating g... 8 | 49
abnormal eye morphology 7 | 38
decreased circulating free fat... 7 | 39
improved glucose tolerance 7 | 56
increased blood urea nitrogen ... 7 | 44
increased bone mineral density 7 | 52
increased circulating triglyce... 7 | 24
increased heart weight 7 | 37
increased sacral vertebrae num... 7 | 62
abnormal behavioral response t... 6 | 52
abnormal lens morphology 6 | 73
abnormal neural tube closure 6 | 37
abnormal seminal vesicle morph... 6 | 47
decreased circulating alkaline... 6 | 41
decreased circulating amylase ... 6 | 24
decreased circulating triglyce... 6 | 83
decreased hemoglobin content 6 | 53
decreased lumbar vertebrae num... 6 | 62
male infertility 6 | 62
small testis 6 | 37
thrombocytosis 6 | 23
tremors 6 | 34
abnormal coat-hair pigmentatio... 5 | 54
abnormal hindbrain development 5 | 24
decreased CD4-positive, CD25-p... 5 | 24
decreased T cell number 5 | 31
decreased blood urea nitrogen ... 5 | 31
decreased circulating LDL chol... 5 | 37
decreased circulating bilirubi... 5 | 14
decreased circulating insulin ... 5 | 75
decreased lymphocyte cell numb... 5 | 9
decreased mean corpuscular hem... 5 | 34
increased body weight 5 | 42
increased circulating calcium ... 5 | 32
increased circulating chloride... 5 | 43
increased circulating phosphat... 5 | 24
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
increased total body fat amoun... 5 | 57
abnormal cornea morphology 4 | 24
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal locomotor activation 4 | 26
abnormal tooth morphology 4 | 24
abnormal vocalization 4 | 21
absent startle reflex 4 | 15
decreased circulating iron lev... 4 | 25
decreased circulating total pr... 4 | 41
decreased eosinophil cell numb... 4 | 41
decreased heart weight 4 | 44
decreased rib number 4 | 59
decreased total retina thickne... 4 | 20
embryonic growth retardation 4 | 28
enlarged spleen 4 | 26
female infertility 4 | 34
increased circulating serum al... 4 | 25
persistence of hyaloid vascula... 4 | 22
short tibia 4 | 82

Disease

ovarian cancer 1,014 | 8,491
osteosarcoma 862 | 7,933
psoriasis 741 | 6,685
medulloblastoma, large-cell 690 | 6,234
lung cancer 600 | 4,473
glioblastoma 599 | 5,572
Cancer 574 | 2,346
atypical teratoid / rhabdoid tumor 497 | 4,369
Breast cancer 436 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 391 | 3,289
malignant mesothelioma 384 | 3,163
primitive neuroectodermal tumor 358 | 3,031
invasive ductal carcinoma 336 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 332 | 2,988
non-small cell lung cancer 324 | 2,798
lung adenocarcinoma 320 | 2,714
oligodendroglioma 320 | 2,849
Carcinoma 310 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 290 | 2,956
pediatric high grade glioma 289 | 2,712
group 3 medulloblastoma 282 | 2,254
ependymoma 275 | 2,514
pancreatic cancer 271 | 2,300
pilocytic astrocytoma 261 | 3,086
subependymal giant cell astrocytoma 253 | 2,287
Pick disease 249 | 1,893
diabetes mellitus 246 | 1,663
astrocytic glioma 242 | 2,241
lung carcinoma 238 | 2,844
Multiple myeloma 236 | 1,327
astrocytoma 224 | 1,493
group 4 medulloblastoma 220 | 1,875
breast carcinoma 219 | 1,614
Rheumatoid Arthritis 217 | 1,170
adult high grade glioma 213 | 2,148
dermatomyositis 213 | 966
acute quadriplegic myopathy 209 | 1,157
ulcerative colitis 209 | 2,087
colon cancer 202 | 1,475
ductal carcinoma in situ 200 | 1,745
pituitary cancer 200 | 1,972
juvenile dermatomyositis 187 | 1,189
adrenocortical carcinoma 179 | 1,427
tuberculosis 176 | 1,563
interstitial cystitis 174 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 174 | 1,795
medulloblastoma 164 | 1,524
cystic fibrosis 161 | 1,670
Waldenstrons macroglobulinemia 159 | 764
sonic hedgehog group medulloblastoma 156 | 1,482
posterior fossa group A ependymoma 155 | 1,511
primary pancreatic ductal adenocarcinoma 152 | 1,271
posterior fossa group B ependymoma 128 | 1,530
cutaneous lupus erythematosus 118 | 1,056
spina bifida 118 | 1,064
acute myeloid leukemia 116 | 785
atypical teratoid/rhabdoid tumor 114 | 1,095
nasopharyngeal carcinoma 109 | 1,056
Atopic dermatitis 108 | 944
Mammary Neoplasms 107 | 410
progressive supranuclear palsy 100 | 674
primary Sjogren syndrome 96 | 788
Intellectual disability 94 | 573
tuberculosis and treatment for 6 months 94 | 686
Amyotrophic Lateral Sclerosis 91 | 432
Alzheimer's disease 90 | 644
Endometriosis 84 | 535
esophageal adenocarcinoma 83 | 737
Arthritis 82 | 248
Multiple Sclerosis 81 | 498
gastric carcinoma 81 | 832
non primary Sjogren syndrome sicca 79 | 840
Prostatic Neoplasms 78 | 471
Kidney disease 77 | 397
Hypersensitivity reaction type II disease 76 | 235
Ankylosing spondylitis 75 | 138
active Crohn's disease 75 | 918
aldosterone-producing adenoma 73 | 664
pancreatic carcinoma 72 | 567
hepatocellular carcinoma 71 | 550
Acquired immunodeficiency syndrome 69 | 164
Neurodegenerative disease 69 | 383
Obesity 69 | 616
Down syndrome 68 | 548
gastric cancer 68 | 436
autosomal dominant Emery-Dreifuss muscular dystrophy 67 | 499
Juvenile rheumatoid arthritis 63 | 105
Stevens-Johnson syndrome 62 | 91
Uveitis 62 | 103
non-small cell lung carcinoma 61 | 413
Schizophrenia 60 | 503
Human immunodeficiency virus infectious disease 59 | 129
IGA Glomerulonephritis 59 | 454
sarcoidosis 58 | 368
Behcet's disease 57 | 74
Duchenne muscular dystrophy 56 | 602
Stomach Neoplasms 56 | 282
Parkinson's disease 55 | 364
Anemia 54 | 252
Liver carcinoma 54 | 217

Tissue

Male tissues 1,645 | 17,968
Nervous System 1,645 | 18,560
Female tissues 1,644 | 18,646
Blood and immune system 1,643 | 17,994
Digestive Tract 1,642 | 18,472
Endocrine System 1,641 | 18,511
Urinary Tract 1,641 | 18,443
Cardiovascular System 1,640 | 17,957
Liver and Pancreas 1,640 | 18,135
Respiratory system 1,628 | 17,483
Skin and soft tissues 1,615 | 18,114

Target Family

Non-IDG 921 | 11,969
Enzyme 284 | 4,146
Transcription Factor 263 | 1,400
Kinase 116 | 634
Epigenetic 71 | 242
GPCR 24 | 408
Ion Channel 24 | 341
Nuclear Receptor 15 | 48
TF/Epigenetic 15 | 38
Transporter 8 | 473

UniProt Keyword

Ubl conjugation 1,741 | 1,741
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Tyrosine-protein kinase Fer FER Tchem Kinase -1.84299 53.1 358
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.11581 129.5 456
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
E3 ubiquitin-protein ligase TRIM17 TRIM17 Tbio Enzyme -1.93165 73.2 100
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
TELO2-interacting protein 1 homolog TTI1 Tbio Non-IDG -0.83395 6.09 63
WD repeat-containing protein 70 WDR70 Tdark Non-IDG 0.90 0.28 20
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.84839 135.6 220
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806