Development Level

Tbio 11 | 10,625

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal neural tube closure 1 | 37
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
decreased bone mineral content 1 | 157
decreased circulating free fat... 1 | 39
embryonic growth retardation 1 | 28
increased circulating sodium l... 1 | 71
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
persistence of hyaloid vascula... 1 | 22
vertebral fusion 1 | 23

Disease

Multiple acyl-CoA dehydrogenase deficiency 7 | 26
osteosarcoma 7 | 7,933
COENZYME Q10 DEFICIENCY, PRIMARY, 1 5 | 6
ovarian cancer 4 | 8,491
psoriasis 4 | 6,685
Nephrotic Syndrome 3 | 48
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
invasive ductal carcinoma 3 | 2,950
Cerebellar Ataxia 2 | 72
Coenzyme Q10 deficiency disease 2 | 3
Leigh disease 2 | 81
Neurodegenerative disease 2 | 383
Parkinson's disease 2 | 364
acute myeloid leukemia 2 | 785
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 2,514
medulloblastoma, large-cell 2 | 6,234
non-small cell lung cancer 2 | 2,798
posterior fossa group B ependymoma 2 | 1,530
Amyotrophic Lateral Sclerosis 1 | 432
Babesiosis 1 | 13
COENZYME Q10 DEFICIENCY 1 | 1
Cerebellar Dysmetria 1 | 2
Coenzyme Q10 deficiency, primary, 2 1 | 1
Coenzyme Q10 deficiency, primary, 3 1 | 1
Coenzyme Q10 deficiency, primary, 4 1 | 1
Coenzyme Q10 deficiency, primary, 5 1 | 1
Coenzyme Q10 deficiency, primary, 6 1 | 1
Coenzyme Q10 deficiency, primary, 7 1 | 1
Coenzyme Q10 deficiency, primary, 8 1 | 1
Corneal dystrophy 1 | 15
Corneal dystrophy, Schnyder type 1 | 1
Cystinosis 1 | 15
Duchenne muscular dystrophy 1 | 602
Early myoclonic encephalopathy 1 | 9
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome 1 | 1
Intellectual disability 1 | 573
MULTIPLE SYSTEM ATROPHY 1, SUSCEPTIBILITY TO 1 | 1
Mitochondrial complex I deficiency 1 | 37
Mitochondrial encephalomyopathy 1 | 18
Multiple system atrophy 1 | 27
Multiple system atrophy 1 1 | 1
Neurilemmoma 1 | 20
Neurofibromatosis 3 1 | 4
Newborn respiratory distress syndrome 1 | 11
Nystagmus Adverse Event 1 | 2
Restless legs syndrome 1 | 28
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 9 1 | 1
Schnyder Corneal Dystrophy 1 | 24
Schnyder crystalline corneal dystrophy 1 | 1
Schwannomatosis 1 | 4
Shy-Drager Syndrome 1 | 2
Slurred speech 1 | 2
Spastic ataxia 1 | 13
adrenocortical carcinoma 1 | 1,427
astrocytic glioma 1 | 2,241
astrocytoma 1 | 1,493
atypical teratoid / rhabdoid tumor 1 | 4,369
glioblastoma 1 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
juvenile dermatomyositis 1 | 1,189
lung cancer 1 | 4,473
malignant mesothelioma 1 | 3,163
nasopharyngeal carcinoma 1 | 1,056
pancreatic cancer 1 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
primary pancreatic ductal adenocarcinoma 1 | 1,271
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 1,563

Tissue

Blood and immune system 11 | 17,994
Cardiovascular System 11 | 17,957
Digestive Tract 11 | 18,472
Endocrine System 11 | 18,511
Female tissues 11 | 18,646
Liver and Pancreas 11 | 18,135
Male tissues 11 | 17,968
Nervous System 11 | 18,560
Respiratory system 11 | 17,483
Skin and soft tissues 11 | 18,114
Urinary Tract 11 | 18,443

Target Family

Enzyme 8 | 4,146
Non-IDG 2 | 11,969
Kinase 1 | 634

UniProt Keyword

Ubiquinone biosynthesis 11 | 11
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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