Development Level

Tclin 14 | 602
Tbio 2 | 10,625

IMPC Phenotype

preweaning lethality, complete... 3 | 633
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 2
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased lactate dehydrogenas... 1 | 14
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased startle reflex 1 | 38

Disease

Diabetes mellitus type 2 14 | 69
Mitochondrial complex I deficiency 14 | 37
Treatment Refractory Type 2 Diabetes Mellitus 14 | 53
Leigh disease 13 | 81
Leigh syndrome 10 | 34
Mitochondrial Complex 1 Deficiency 10 | 28
Leber hereditary optic neuropathy 8 | 17
Leber's optic atrophy 8 | 10
Optic Atrophy, Hereditary, Leber 8 | 14
ovarian cancer 8 | 8,491
Mitochondrial myopathy 7 | 24
NADH:Q(1) Oxidoreductase deficiency 7 | 20
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 6 | 14
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 6 | 9
osteosarcoma 6 | 7,933
MELAS syndrome 5 | 17
LEBER OPTIC ATROPHY AND DYSTONIA 4 | 4
Lactic acidosis 4 | 43
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome 4 | 5
Multiple myeloma 4 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Dystonia 3 | 77
Mitochondrial Encephalomyopathies 3 | 11
Optic atrophy 3 | 43
Wolff-Parkinson-White syndrome 3 | 11
ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL 2 | 2
Alzheimer disease mitochondrial 2 | 2
Alzheimer's disease 2 | 644
Amyloidosis 2 | 68
Cardiomyopathies 2 | 90
Degenerative polyarthritis 2 | 93
Disease Progression 2 | 125
Hypertrophic Cardiomyopathy 2 | 56
Leber hereditary optic neuropathy with dystonia 2 | 2
Malaria 2 | 140
Myopathy 2 | 128
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Obesity 2 | 616
Optic Atrophies, Hereditary 2 | 2
PARKINSON DISEASE, LATE-ONSET 2 | 20
Parkinson Disease 6, Autosomal Recessive Early-Onset 2 | 3
Pick disease 2 | 1,893
Retinitis pigmentosa 2 | 156
Schizophrenia 2 | 503
Stomach Neoplasms 2 | 282
adult high grade glioma 2 | 2,148
aldosterone-producing adenoma 2 | 664
astrocytic glioma 2 | 2,241
diabetes mellitus 2 | 1,663
ependymoma 2 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung cancer 2 | 4,473
medulloblastoma, large-cell 2 | 6,234
non primary Sjogren syndrome sicca 2 | 840
ulcerative colitis 2 | 2,087
Alexander disease 1 | 9
Alzheimer Disease 1 | 10
Amblyopia 1 | 24
Babesiosis 1 | 13
Bipolar Disorder 1 | 266
Blindness 1 | 84
Breast Cancer, Familial 1 | 12
Carcinoma of colon 1 | 32
Cardiomyopathy 1 | 110
Carnitine palmitoyltransferase II deficiency 1 | 16
Cataract 1 | 104
Chagas disease 1 | 34
Coenurosis 1 | 4
Colon Carcinoma 1 | 25
Cysticercosis 1 | 12
Diabetes Mellitus, Experimental 1 | 106
Diphyllobothriasis 1 | 6
Eastern equine encephalitis 1 | 15
Echinococcosis 1 | 28
Epilepsy 1 | 346
Fascioliasis 1 | 18
Lactocele 1 | 3
Leishmaniasis 1 | 49
MERRF syndrome 1 | 5
Macrocephaly 1 | 5
Mammary Neoplasms 1 | 410
Methemoglobinemia 1 | 17
Multiple Acyl Coenzyme A Dehydrogenase Deficiency 1 | 3
Multiple acyl-CoA dehydrogenase deficiency 1 | 26
Neutral lipid storage disease 1 | 14
Oral candidiasis 1 | 9
Parkinson's disease 1 | 364
Pearson syndrome 1 | 17
Pneumocystosis 1 | 18
Reye syndrome 1 | 11
Scotoma 1 | 7
Sudden infant death syndrome 1 | 34
Systemic primary carnitine deficiency disease 1 | 16
Tungiasis 1 | 2
Wolfram syndrome 1 | 11
hereditary spastic paraplegia 1 | 313
limb girdle muscular dystrophy 2A 1 | 156
ovarian neoplasm 1 | 97

Tissue

Blood and immune system 16 | 17,994
Cardiovascular System 16 | 17,957
Digestive Tract 16 | 18,472
Endocrine System 16 | 18,511
Female tissues 16 | 18,646
Liver and Pancreas 16 | 18,135
Male tissues 16 | 17,968
Nervous System 16 | 18,560
Respiratory system 16 | 17,483
Skin and soft tissues 16 | 18,114
Urinary Tract 16 | 18,443

Target Family

Enzyme 15 | 4,146
Non-IDG 1 | 11,969

UniProt Keyword

Ubiquinone 16 | 16
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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