Development Level

Tbio 151 | 11,651
Tchem 27 | 1,388
Tdark 3 | 6,593
Tclin 1 | 612

Collection

GPCR: IDG Consortium (Targets) 2 | 126
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
increased circulating sodium l... 5 | 71
abnormal behavior 4 | 298
abnormal lens morphology 4 | 81
embryonic lethality prior to o... 4 | 239
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
increased circulating alkaline... 2 | 122
male infertility 2 | 123
thrombocytopenia 2 | 56
abnormal coat- hair morphology 1 | 19
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal stomach morphology 1 | 10
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating insulin ... 1 | 76
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased threshold for audito... 1 | 26
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 130 | 11,493
Cancer 121 | 2,499
ovarian cancer 115 | 8,520
osteosarcoma 97 | 7,950
lung cancer 76 | 4,740
medulloblastoma, large-cell 76 | 6,241
glioblastoma 74 | 5,792
psoriasis 72 | 6,694
atypical teratoid / rhabdoid tumor 65 | 5,112
Breast cancer 63 | 3,578
ependymoma 60 | 4,679
malignant mesothelioma 59 | 3,232
group 3 medulloblastoma 57 | 4,104
Kidney cancer 51 | 2,613
adult high grade glioma 49 | 3,801
non-small cell lung cancer 44 | 2,890
invasive ductal carcinoma 43 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
oligodendroglioma 41 | 2,850
pancreatic cancer 41 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
lung adenocarcinoma 38 | 2,716
primitive neuroectodermal tumor 38 | 3,035
astrocytic glioma 33 | 2,597
pituitary cancer 33 | 1,972
lung carcinoma 32 | 2,843
breast carcinoma 31 | 1,638
subependymal giant cell astrocytoma 31 | 2,287
tuberculosis 30 | 2,010
ductal carcinoma in situ 29 | 1,745
Astrocytoma, Pilocytic 27 | 3,081
Intellectual disability 26 | 1,016
Pick disease 25 | 1,894
Autosomal recessive predisposition 24 | 1,442
adrenocortical carcinoma 24 | 1,428
ulcerative colitis 24 | 1,819
Stomach Neoplasms 23 | 300
acute quadriplegic myopathy 23 | 1,158
cystic fibrosis 23 | 1,696
spina bifida 23 | 1,074
Breast Neoplasms 22 | 445
astrocytoma 22 | 1,146
colon cancer 22 | 1,478
Mammary Neoplasms 21 | 425
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
Lung Neoplasms 20 | 232
diabetes mellitus 20 | 1,728
interstitial cystitis 20 | 2,312
Epilepsy 19 | 792
juvenile dermatomyositis 19 | 1,187
medulloblastoma 19 | 720
Dull intelligence 18 | 645
Liver cancer 18 | 604
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Renal Cell Carcinoma 18 | 214
Seizures 18 | 596
group 4 medulloblastoma 18 | 1,855
nasopharyngeal carcinoma 18 | 1,058
Adenoma 17 | 167
Prostatic Neoplasms 17 | 495
cutaneous lupus erythematosus 17 | 1,057
Multiple myeloma 16 | 1,332
Muscle hypotonia 16 | 571
Schizophrenia 16 | 1,160
active ulcerative colitis 16 | 764
esophageal adenocarcinoma 16 | 737
gastric carcinoma 16 | 807
Cognitive delay 15 | 608
Colorectal Neoplasms 15 | 243
Global developmental delay 15 | 608
Liver carcinoma 15 | 240
Mental and motor retardation 15 | 608
Short stature 15 | 531
Squamous cell carcinoma 15 | 129
dermatomyositis 15 | 966
Carcinoma, Hepatocellular 14 | 228
Melanoma 14 | 711
Pancreatic Neoplasm 14 | 85
hepatocellular carcinoma 14 | 547
Nausea and vomiting 13 | 97
Rheumatoid arthritis 13 | 1,191
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
Colonic Neoplasms 12 | 142
Lymphoma 12 | 81
Pancreatic Neoplasms 12 | 85
Skin cancer 12 | 469
Somatic mutation 12 | 61
primary pancreatic ductal adenocarcinoma 12 | 1,109
Abdominal Pain 11 | 98
Cataract 11 | 297
Endometrial cancer 11 | 311
Orbital separation excessive 11 | 244
aldosterone-producing adenoma 11 | 665
primary Sjogren syndrome 11 | 735
progressive supranuclear palsy 11 | 676
mucosa-associated lymphoid tissue lymphoma 10 | 484

Tissue

Digestive Tract 180 | 17,369
Endocrine System 180 | 18,159
Female tissues 179 | 17,400
Male tissues 179 | 17,142
Skin and soft tissues 179 | 17,230
Urinary Tract 179 | 16,678
Nervous System 178 | 16,725
Blood and immune system 177 | 16,909
Liver and Pancreas 176 | 16,750
Respiratory system 176 | 16,393
Cardiovascular System 171 | 15,192

Target Family

Non-IDG 94 | 12,091
Enzyme 42 | 4,145
Kinase 17 | 634
Transcription Factor 16 | 1,400
Epigenetic 8 | 242
GPCR 3 | 408
TF/Epigenetic 1 | 38
Transporter 1 | 473

UniProt Keyword

Tumor suppressor 182 | 182
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Reversion-inducing cysteine-rich protein with Kazal motifs RECK Tbio Non-IDG -2.24752 194.4 192
Malignant T-cell-amplified sequence 1 MCTS1 Tbio Non-IDG -0.79616 5.89 149
Oxidoreductase HTATIP2 HTATIP2 Tbio Enzyme -1.67998 59.4 218
Microtubule-associated tumor suppressor 1 MTUS1 Tbio Non-IDG -1.78224 64.2 121
Rho GTPase-activating protein 7 DLC1 Tbio Enzyme -1.93185 106.7 137
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.03717 75.4 82