Development Level

Tbio 20 | 10,625
Tchem 3 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased lean body mass 1 | 195
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71

Disease

ovarian cancer 18 | 8,484
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
psoriasis 11 | 6,685
Multiple myeloma 10 | 1,327
osteosarcoma 9 | 7,933
glioblastoma 8 | 5,572
medulloblastoma, large-cell 8 | 6,234
Breast cancer 7 | 3,094
lung cancer 7 | 4,466
Pick disease 6 | 1,893
astrocytic glioma 6 | 2,241
atypical teratoid / rhabdoid tumor 6 | 4,369
Degenerative polyarthritis 5 | 93
Hemangioma 5 | 35
Leigh disease 5 | 81
Neoplastic Syndromes, Hereditary 5 | 48
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
lung adenocarcinoma 5 | 2,713
Cancer 4 | 2,346
Chondroma 4 | 12
Gastrointestinal stromal tumor 4 | 61
Lactic acidosis 4 | 42
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Waldenstrons macroglobulinemia 4 | 765
adult high grade glioma 4 | 2,148
invasive ductal carcinoma 4 | 2,950
malignant mesothelioma 4 | 3,162
medulloblastoma 4 | 1,524
oligodendroglioma 4 | 2,849
pilocytic astrocytoma 4 | 3,086
primitive neuroectodermal tumor 4 | 3,031
Carcinoma 3 | 2,147
Carney Triad 3 | 3
Disease Progression 3 | 125
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Neurofibromatosis 3 | 37
Obesity 3 | 616
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Pyruvate decarboxylase deficiency 3 | 15
Sideroblastic anemia with spinocerebellar ataxia 3 | 6
Stomach Neoplasms 3 | 282
aldosterone-producing adenoma 3 | 664
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 2,514
extra-adrenal pheochromocytoma 3 | 7
group 4 medulloblastoma 3 | 1,875
hereditary spastic paraplegia 3 | 313
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung cancer 3 | 2,798
pituitary cancer 3 | 1,972
tuberculosis 3 | 1,557
ulcerative colitis 3 | 2,087
COWDEN-LIKE SYNDROME (disorder) 2 | 2
Cholangiocarcinoma 2 | 32
Cowden disease 2 | 16
D-2-hydroxyglutaric aciduria 2 | 9
DOID:2627 2 | 14
Dystonia 2 | 77
Enchondromatosis 2 | 4
Hereditary Paraganglioma-Pheochromocytoma Syndrome 2 | 3
Immune system cancer 2 | 38
Inflammatory dermatosis 2 | 38
Interval angle-closure glaucoma 2 | 2
Liver carcinoma 2 | 217
Maffucci syndrome 2 | 7
Mitochondrial myopathy 2 | 23
Myelofibrosis 2 | 11
Myocardial Ischemia 2 | 169
Ollier disease 2 | 15
Papilloma 2 | 27
Parkinson's disease 2 | 364
Pheochromocytoma 2 | 22
Pyruvate Dehydrogenase Complex Deficiency Disease 2 | 2
Renal Cell Carcinoma 2 | 199
Thyroid cancer 2 | 25
Tropical spastic paraparesis 2 | 17
adrenocortical carcinoma 2 | 1,427
astrocytoma 2 | 1,493
atypical teratoid/rhabdoid tumor 2 | 1,095
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
nasopharyngeal carcinoma 2 | 1,056
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pediatric high grade glioma 2 | 2,712
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
Angioimmunoblastic Lymphadenopathy 1 | 4
Coffin-Lowry syndrome 1 | 10
Liver Cirrhosis 1 | 101
Neoplasm Invasiveness 1 | 127
Vasomotor rhinitis 1 | 15

Tissue

Blood and immune system 24 | 17,995
Cardiovascular System 24 | 17,958
Digestive Tract 24 | 18,473
Endocrine System 24 | 18,512
Female tissues 24 | 18,647
Liver and Pancreas 24 | 18,136
Male tissues 24 | 17,969
Nervous System 24 | 18,561
Respiratory system 24 | 17,484
Urinary Tract 24 | 18,444
Skin and soft tissues 23 | 18,115

Target Family

Enzyme 24 | 4,146

UniProt Keyword

Tricarboxylic acid cycle 24 | 24
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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