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Target Filters...

Development Level

Tbio 1,352 | 11,651
Tdark 292 | 6,593
Tclin 206 | 612
Tchem 135 | 1,388

Collection

RFA-RM-18-021 102 | 328
Ion Channel: IDG Consortium (T... 99 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 157 | 979
preweaning lethality, incomple... 71 | 499
embryonic lethality prior to t... 44 | 278
abnormal behavior 43 | 298
embryonic lethality prior to o... 37 | 239
abnormal embryo size 35 | 220
decreased total body fat amoun... 30 | 207
enlarged heart 25 | 210
decreased vertical activity 23 | 208
increased lean body mass 23 | 172
hyperactivity 22 | 148
increased circulating alkaline... 22 | 122
decreased bone mineral content 21 | 151
abnormal heart morphology 20 | 162
cataract 20 | 92
decreased body weight 20 | 161
increased mean corpuscular hem... 20 | 96
abnormal seminal vesicle morph... 19 | 114
increased total body fat amoun... 18 | 134
abnormal bone structure 17 | 187
abnormal lens morphology 17 | 81
decreased bone mineral density 17 | 126
embryonic growth retardation 17 | 106
decreased circulating choleste... 16 | 93
decreased circulating glucose ... 16 | 126
impaired glucose tolerance 16 | 75
increased startle reflex 16 | 112
abnormal retina morphology 15 | 71
hypoactivity 15 | 132
increased bone mineral content 15 | 108
increased mean corpuscular vol... 15 | 92
increased or absent threshold ... 15 | 101
decreased circulating triglyce... 14 | 79
decreased grip strength 14 | 116
decreased mean corpuscular hem... 14 | 50
decreased fasted circulating g... 13 | 65
increased fasted circulating g... 13 | 76
decreased circulating serum al... 12 | 82
decreased lean body mass 12 | 135
decreased prepulse inhibition 12 | 82
increased bone mineral density 12 | 72
increased circulating HDL chol... 12 | 80
abnormal epididymis morphology 11 | 42
abnormal kidney morphology 11 | 65
abnormal sleep behavior 11 | 70
decreased body length 11 | 101
decreased circulating insulin ... 11 | 76
decreased erythrocyte cell num... 11 | 62
decreased hemoglobin content 11 | 68
decreased lymphocyte cell numb... 11 | 83
edema 11 | 59
abnormal eye morphology 10 | 68
decreased caudal vertebrae num... 10 | 53
decreased circulating HDL chol... 10 | 68
increased circulating sodium l... 10 | 71
increased circulating triglyce... 10 | 42
limb grasping 10 | 41
prenatal lethality prior to he... 10 | 87
short tibia 10 | 97
abnormal gait 9 | 69
decreased circulating alkaline... 9 | 46
decreased mean corpuscular vol... 9 | 79
decreased red blood cell distr... 9 | 41
enlarged epididymis 9 | 31
improved glucose tolerance 9 | 79
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
increased monocyte cell number 9 | 63
abnormal coat-hair pigmentatio... 8 | 64
abnormal spleen morphology 8 | 55
decreased circulating LDL chol... 8 | 38
decreased circulating creatini... 8 | 39
decreased hematocrit 8 | 46
decreased leukocyte cell numbe... 8 | 73
enlarged spleen 8 | 41
increased grip strength 8 | 41
increased mean platelet volume 8 | 45
abnormal bone mineralization 7 | 38
absent pinna reflex 7 | 23
decreased circulating amylase ... 7 | 28
decreased circulating calcium ... 7 | 36
increased body length 7 | 32
increased circulating serum al... 7 | 22
increased mean corpuscular hem... 7 | 36
pallor 7 | 34
small testis 7 | 58
abnormal behavioral response t... 6 | 66
abnormal cranium morphology 6 | 36
abnormal embryo turning 6 | 31
abnormal neural tube closure 6 | 46
abnormal testis morphology 6 | 43
cardiovascular system phenotyp... 6 | 36
decreased circulating iron lev... 6 | 32
decreased circulating sodium l... 6 | 22
hydrometra 6 | 53
increased hematocrit 6 | 46
increased prepulse inhibition 6 | 32
persistence of hyaloid vascula... 6 | 33
prenatal lethality 6 | 28
thrombocytosis 6 | 27

Disease

Carcinoma 1,240 | 11,493
ovarian cancer 964 | 8,520
osteosarcoma 846 | 7,950
medulloblastoma, large-cell 744 | 6,241
psoriasis 707 | 6,694
glioblastoma 680 | 5,792
atypical teratoid / rhabdoid tumor 618 | 5,112
ependymoma 561 | 4,679
lung cancer 491 | 4,740
group 3 medulloblastoma 450 | 4,104
adult high grade glioma 449 | 3,801
oligodendroglioma 381 | 2,850
Breast cancer 369 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 369 | 3,291
Astrocytoma, Pilocytic 359 | 3,081
primitive neuroectodermal tumor 351 | 3,035
astrocytic glioma 347 | 2,597
Kidney cancer 330 | 2,613
lung carcinoma 329 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 325 | 2,955
malignant mesothelioma 320 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 303 | 2,989
invasive ductal carcinoma 297 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 295 | 1,962
Pick disease 276 | 1,894
non-small cell lung cancer 275 | 2,890
lung adenocarcinoma 274 | 2,716
subependymal giant cell astrocytoma 268 | 2,287
pancreatic cancer 248 | 2,398
Autosomal recessive predisposition 239 | 1,442
pituitary cancer 226 | 1,972
Multiple myeloma 204 | 1,332
tuberculosis 203 | 2,010
interstitial cystitis 201 | 2,312
Epilepsy 196 | 792
group 4 medulloblastoma 192 | 1,855
diabetes mellitus 190 | 1,728
Schizophrenia 181 | 1,160
ulcerative colitis 179 | 1,819
ductal carcinoma in situ 176 | 1,745
cystic fibrosis 167 | 1,696
breast carcinoma 161 | 1,638
Cancer 152 | 2,499
colon cancer 152 | 1,478
Intellectual disability 150 | 1,016
acute quadriplegic myopathy 142 | 1,158
adrenocortical carcinoma 139 | 1,428
astrocytoma 136 | 1,146
Rheumatoid arthritis 125 | 1,191
pediatric high grade glioma 125 | 1,064
Seizures 124 | 596
active Crohn's disease 124 | 922
active ulcerative colitis 122 | 764
Bipolar Disorder 119 | 666
juvenile dermatomyositis 117 | 1,187
Cognitive delay 114 | 608
Global developmental delay 114 | 608
Mental and motor retardation 114 | 608
non primary Sjogren syndrome sicca 113 | 891
primary pancreatic ductal adenocarcinoma 109 | 1,109
Muscle hypotonia 105 | 571
dermatomyositis 104 | 966
Dull intelligence 100 | 645
Low intelligence 100 | 645
Mental Retardation 100 | 645
Mental deficiency 100 | 645
Poor school performance 100 | 645
spina bifida 100 | 1,074
progressive supranuclear palsy 99 | 676
Obesity 98 | 678
Waldenstrons macroglobulinemia 97 | 765
cutaneous lupus erythematosus 95 | 1,057
Cerebellar Ataxia 92 | 304
Alzheimer's disease 91 | 658
gastric carcinoma 86 | 807
Liver Cirrhosis, Experimental 84 | 769
Melanoma 82 | 711
acute myeloid leukemia 80 | 783
Atopic dermatitis 78 | 952
Failure to gain weight 78 | 365
Pediatric failure to thrive 78 | 365
nasopharyngeal carcinoma 78 | 1,058
Multiple Sclerosis 77 | 540
Nystagmus 77 | 317
Liver cancer 76 | 604
medulloblastoma 75 | 720
Hypertension 74 | 396
aldosterone-producing adenoma 74 | 665
pancreatic carcinoma 74 | 562
Neurodegenerative disease 72 | 414
Short stature 70 | 531
esophageal adenocarcinoma 67 | 737
Parkinson's disease 66 | 392
Skin cancer 65 | 469
Autistic Disorder 64 | 364
Kidney disease 61 | 430
Depressive disorder 60 | 409
mucosa-associated lymphoid tissue lymphoma 59 | 484
Duchenne muscular dystrophy 58 | 601
Infantile onset 58 | 238

Tissue

Endocrine System 1,927 | 18,159
Digestive Tract 1,887 | 17,369
Female tissues 1,875 | 17,400
Skin and soft tissues 1,862 | 17,230
Male tissues 1,861 | 17,142
Nervous System 1,860 | 16,725
Urinary Tract 1,835 | 16,678
Liver and Pancreas 1,833 | 16,750
Blood and immune system 1,824 | 16,909
Respiratory system 1,776 | 16,393
Cardiovascular System 1,653 | 15,192

Target Family

Non-IDG 941 | 12,091
Transporter 422 | 473
Ion Channel 344 | 344
Enzyme 264 | 4,145
Kinase 7 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

UniProt Keyword

Transport 1,985 | 1,985
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
Synaptic vesicle 2-related protein SVOP Tdark Non-IDG -0.57678 4.35 90
Exportin-4 XPO4 Tbio Non-IDG -1.62873 40.7 26
Sorting nexin-22 SNX22 Tdark Non-IDG -0.21085 1.62 25