1. Home
  2. Targets
Target Filters...

Development Level

Tbio 1,263 | 11,178
Tdark 285 | 6,569
Tchem 231 | 1,885
Tclin 206 | 612

Collection

Ion Channel: IDG Consortium (T... 99 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 157 | 979
preweaning lethality, incomple... 71 | 499
embryonic lethality prior to t... 44 | 278
abnormal behavior 43 | 298
embryonic lethality prior to o... 37 | 239
abnormal embryo size 35 | 220
decreased total body fat amoun... 30 | 207
enlarged heart 25 | 210
decreased vertical activity 23 | 208
increased lean body mass 23 | 172
hyperactivity 22 | 148
increased circulating alkaline... 22 | 122
decreased bone mineral content 21 | 151
abnormal heart morphology 20 | 162
cataract 20 | 92
decreased body weight 20 | 161
increased mean corpuscular hem... 20 | 96
abnormal seminal vesicle morph... 19 | 114
increased total body fat amoun... 18 | 134
abnormal bone structure 17 | 187
abnormal lens morphology 17 | 81
decreased bone mineral density 17 | 126
embryonic growth retardation 17 | 106
decreased circulating choleste... 16 | 93
decreased circulating glucose ... 16 | 126
impaired glucose tolerance 16 | 75
increased startle reflex 16 | 112
abnormal retina morphology 15 | 71
hypoactivity 15 | 132
increased bone mineral content 15 | 108
increased mean corpuscular vol... 15 | 92
increased or absent threshold ... 15 | 101
decreased circulating triglyce... 14 | 79
decreased grip strength 14 | 116
decreased mean corpuscular hem... 14 | 50
decreased fasted circulating g... 13 | 65
increased fasted circulating g... 13 | 76
decreased circulating serum al... 12 | 82
decreased lean body mass 12 | 135
decreased prepulse inhibition 12 | 82
increased bone mineral density 12 | 72
increased circulating HDL chol... 12 | 80
abnormal epididymis morphology 11 | 42
abnormal kidney morphology 11 | 65
abnormal sleep behavior 11 | 70
decreased body length 11 | 101
decreased circulating insulin ... 11 | 76
decreased erythrocyte cell num... 11 | 62
decreased hemoglobin content 11 | 68
decreased lymphocyte cell numb... 11 | 83
edema 11 | 59
abnormal eye morphology 10 | 68
decreased caudal vertebrae num... 10 | 53
decreased circulating HDL chol... 10 | 68
increased circulating sodium l... 10 | 71
increased circulating triglyce... 10 | 42
limb grasping 10 | 41
prenatal lethality prior to he... 10 | 87
short tibia 10 | 97
abnormal gait 9 | 69
decreased circulating alkaline... 9 | 46
decreased mean corpuscular vol... 9 | 79
decreased red blood cell distr... 9 | 41
enlarged epididymis 9 | 31
improved glucose tolerance 9 | 79
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
increased monocyte cell number 9 | 63
abnormal coat-hair pigmentatio... 8 | 64
abnormal spleen morphology 8 | 55
decreased circulating LDL chol... 8 | 38
decreased circulating creatini... 8 | 39
decreased hematocrit 8 | 46
decreased leukocyte cell numbe... 8 | 73
enlarged spleen 8 | 41
increased grip strength 8 | 41
increased mean platelet volume 8 | 45
abnormal bone mineralization 7 | 38
absent pinna reflex 7 | 23
decreased circulating amylase ... 7 | 28
decreased circulating calcium ... 7 | 36
increased body length 7 | 32
increased circulating serum al... 7 | 22
increased mean corpuscular hem... 7 | 36
pallor 7 | 34
small testis 7 | 58
abnormal behavioral response t... 6 | 66
abnormal cranium morphology 6 | 36
abnormal embryo turning 6 | 31
abnormal neural tube closure 6 | 46
abnormal testis morphology 6 | 43
cardiovascular system phenotyp... 6 | 36
decreased circulating iron lev... 6 | 32
decreased circulating sodium l... 6 | 22
hydrometra 6 | 53
increased hematocrit 6 | 46
increased prepulse inhibition 6 | 32
persistence of hyaloid vascula... 6 | 33
prenatal lethality 6 | 28
thrombocytosis 6 | 27

Disease

Carcinoma 1,230 | 11,192
ovarian cancer 959 | 8,297
osteosarcoma 839 | 7,766
medulloblastoma, large-cell 738 | 6,086
psoriasis 701 | 6,514
glioblastoma 675 | 5,635
atypical teratoid / rhabdoid tumor 616 | 4,971
ependymoma 556 | 4,559
lung cancer 488 | 4,607
group 3 medulloblastoma 445 | 4,002
adult high grade glioma 444 | 3,701
oligodendroglioma 378 | 2,768
intraductal papillary-mucinous neoplasm (IPMN) 367 | 3,204
Breast cancer 364 | 3,469
Astrocytoma, Pilocytic 356 | 3,006
primitive neuroectodermal tumor 349 | 2,957
astrocytic glioma 345 | 2,530
Kidney cancer 328 | 2,548
lung carcinoma 326 | 2,755
intraductal papillary-mucinous adenoma (IPMA) 321 | 2,872
malignant mesothelioma 317 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 300 | 2,902
invasive ductal carcinoma 296 | 2,867
pancreatic ductal adenocarcinoma liver metastasis 291 | 1,911
Pick disease 275 | 1,856
non-small cell lung cancer 274 | 2,799
lung adenocarcinoma 271 | 2,627
subependymal giant cell astrocytoma 266 | 2,230
pancreatic cancer 247 | 2,322
Autosomal recessive predisposition 239 | 1,407
pituitary cancer 224 | 1,915
Multiple myeloma 204 | 1,296
tuberculosis 202 | 1,963
interstitial cystitis 200 | 2,237
Epilepsy 196 | 775
group 4 medulloblastoma 190 | 1,806
diabetes mellitus 189 | 1,683
Schizophrenia 180 | 1,136
ulcerative colitis 179 | 1,765
ductal carcinoma in situ 175 | 1,686
cystic fibrosis 163 | 1,629
breast carcinoma 161 | 1,589
colon cancer 151 | 1,428
Cancer 150 | 2,388
Intellectual disability 150 | 998
acute quadriplegic myopathy 142 | 1,133
adrenocortical carcinoma 139 | 1,385
astrocytoma 135 | 1,113
pediatric high grade glioma 125 | 1,035
Seizures 124 | 584
Rheumatoid arthritis 123 | 1,156
active Crohn's disease 123 | 882
active ulcerative colitis 122 | 736
Bipolar Disorder 119 | 646
juvenile dermatomyositis 115 | 1,147
Cognitive delay 114 | 596
Global developmental delay 114 | 596
Mental and motor retardation 114 | 596
non primary Sjogren syndrome sicca 113 | 861
primary pancreatic ductal adenocarcinoma 108 | 1,071
Muscle hypotonia 105 | 562
dermatomyositis 104 | 941
Dull intelligence 100 | 634
Low intelligence 100 | 634
Mental Retardation 100 | 634
Mental deficiency 100 | 634
Poor school performance 100 | 634
spina bifida 99 | 1,053
Obesity 98 | 655
progressive supranuclear palsy 98 | 656
Waldenstrons macroglobulinemia 97 | 742
cutaneous lupus erythematosus 95 | 1,016
Cerebellar Ataxia 92 | 302
Alzheimer's disease 91 | 640
gastric carcinoma 85 | 781
Liver Cirrhosis, Experimental 84 | 733
Melanoma 82 | 689
Failure to gain weight 78 | 359
Pediatric failure to thrive 78 | 359
acute myeloid leukemia 78 | 760
Atopic dermatitis 77 | 915
Nystagmus 77 | 309
nasopharyngeal carcinoma 77 | 1,024
Liver cancer 76 | 589
Multiple Sclerosis 76 | 527
medulloblastoma 75 | 702
Hypertension 74 | 372
aldosterone-producing adenoma 73 | 646
pancreatic carcinoma 73 | 555
Neurodegenerative disease 72 | 402
Short stature 70 | 514
esophageal adenocarcinoma 67 | 696
Skin cancer 65 | 451
Parkinson's disease 64 | 378
Autistic Disorder 63 | 358
Kidney disease 60 | 411
Depressive disorder 59 | 401
mucosa-associated lymphoid tissue lymphoma 59 | 473
Duchenne muscular dystrophy 58 | 587
Infantile onset 58 | 236

Tissue

Endocrine System 1,927 | 18,159
Digestive Tract 1,887 | 17,369
Female tissues 1,875 | 17,400
Skin and soft tissues 1,862 | 17,230
Male tissues 1,861 | 17,142
Nervous System 1,860 | 16,725
Urinary Tract 1,835 | 16,678
Liver and Pancreas 1,833 | 16,750
Blood and immune system 1,824 | 16,909
Respiratory system 1,776 | 16,393
Cardiovascular System 1,653 | 15,192

Target Family

Non-IDG 941 | 12,091
Transporter 422 | 473
Ion Channel 344 | 344
Enzyme 264 | 4,145
Kinase 7 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

UniProt Keyword

Transport 1,985 | 1,985
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Solute carrier family 22 member 8 SLC22A8 Tclin Transporter -2.40126 258.4 113
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Acid-sensing ion channel 2 ASIC2 Tbio Ion Channel -2.49683 295.8 140
Ras-related protein Rab-3B RAB3B Tbio Enzyme -1.38932 26.8 121
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Probable phospholipid-transporting ATPase VA ATP10A Tbio Transporter -1.17971 17.2 12