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Target Filters...

Development Level

Tbio 1,209 | 10,625
Tdark 321 | 7,003
Tchem 230 | 1,890
Tclin 204 | 602

Collection

Eligible Ion Channel Proteins 117 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 105 | 633
embryonic lethality prior to t... 33 | 187
abnormal behavior 30 | 226
decreased total body fat amoun... 30 | 186
preweaning lethality, incomple... 27 | 260
embryonic lethality prior to o... 26 | 148
increased circulating alkaline... 24 | 119
decreased lean body mass 22 | 195
decreased bone mineral content 21 | 157
decreased body weight 20 | 174
increased mean corpuscular hem... 20 | 93
abnormal retina morphology 19 | 100
decreased bone mineral density 18 | 126
abnormal bone structure 16 | 131
abnormal lens morphology 16 | 73
decreased circulating triglyce... 15 | 83
decreased grip strength 15 | 123
increased grip strength 15 | 83
decreased circulating glucose ... 14 | 121
decreased rib number 14 | 59
hyperactivity 14 | 108
hypoactivity 14 | 89
abnormal embryo size 13 | 112
decreased circulating choleste... 13 | 85
increased mean corpuscular vol... 13 | 91
increased or absent threshold ... 13 | 128
abnormal retinal pigmentation 12 | 61
decreased body length 12 | 108
decreased circulating insulin ... 12 | 75
decreased circulating serum al... 12 | 79
enlarged heart 12 | 111
increased bone mineral content 12 | 92
increased fasted circulating g... 12 | 68
impaired glucose tolerance 11 | 52
increased bone mineral density 11 | 52
increased circulating sodium l... 11 | 71
decreased caudal vertebrae num... 10 | 49
decreased fasted circulating g... 10 | 49
increased circulating HDL chol... 10 | 63
increased lean body mass 10 | 107
short tibia 10 | 82
abnormal epididymis morphology 9 | 31
decreased circulating HDL chol... 9 | 77
enlarged epididymis 9 | 27
increased circulating choleste... 9 | 53
increased sacral vertebrae num... 9 | 62
increased startle reflex 9 | 38
abnormal coat/hair pigmentatio... 8 | 54
decreased circulating LDL chol... 8 | 37
decreased erythrocyte cell num... 8 | 43
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular hem... 8 | 34
improved glucose tolerance 8 | 56
increased prepulse inhibition 8 | 21
limb grasping 8 | 35
prenatal lethality prior to he... 8 | 64
abnormal bone mineralization 7 | 55
abnormal gait 7 | 51
cardiovascular system phenotyp... 7 | 35
decreased circulating alanine ... 7 | 53
decreased circulating sodium l... 7 | 18
decreased heart weight 7 | 44
decreased mean corpuscular vol... 7 | 50
decreased prepulse inhibition 7 | 52
increased body weight 7 | 42
increased circulating potassiu... 7 | 31
increased hemoglobin content 7 | 45
abnormal cranium morphology 6 | 32
abnormal heart morphology 6 | 51
abnormal kidney morphology 6 | 30
abnormal seminal vesicle morph... 6 | 47
absent pinna reflex 6 | 21
cataract 6 | 26
decreased circulating alkaline... 6 | 41
decreased circulating chloride... 6 | 32
decreased circulating creatini... 6 | 31
decreased circulating free fat... 6 | 39
decreased circulating iron lev... 6 | 25
decreased leukocyte cell numbe... 6 | 54
decreased total retina thickne... 6 | 20
increased blood urea nitrogen ... 6 | 44
increased circulating triglyce... 6 | 24
increased hematocrit 6 | 36
straub tail 6 | 26
abnormal eye morphology 5 | 38
abnormal neural tube closure 5 | 37
abnormal sleep behavior 5 | 63
absent vibrissae 5 | 14
decreased NK T cell number 5 | 28
decreased circulating glycerol... 5 | 19
decreased eosinophil cell numb... 5 | 41
decreased hemoglobin content 5 | 53
increased circulating chloride... 5 | 43
increased circulating free fat... 5 | 17
increased circulating magnesiu... 5 | 10
increased heart weight 5 | 37
increased mean corpuscular hem... 5 | 25
increased total body fat amoun... 5 | 57
persistence of hyaloid vascula... 5 | 22
thrombocytosis 5 | 23

Disease

ovarian cancer 946 | 8,484
osteosarcoma 835 | 7,933
medulloblastoma, large-cell 732 | 6,234
psoriasis 699 | 6,685
glioblastoma 644 | 5,572
atypical teratoid / rhabdoid tumor 511 | 4,369
lung cancer 462 | 4,466
oligodendroglioma 376 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 363 | 3,289
pilocytic astrocytoma 356 | 3,086
primitive neuroectodermal tumor 347 | 3,031
pediatric high grade glioma 344 | 2,712
lung carcinoma 326 | 2,844
ependymoma 324 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 322 | 2,956
Breast cancer 310 | 3,094
malignant mesothelioma 309 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 300 | 2,988
astrocytic glioma 293 | 2,241
invasive ductal carcinoma 291 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 273 | 1,795
Pick disease 272 | 1,893
lung adenocarcinoma 271 | 2,713
Carcinoma 266 | 2,147
subependymal giant cell astrocytoma 265 | 2,287
non-small cell lung cancer 261 | 2,798
pancreatic cancer 231 | 2,300
adult high grade glioma 223 | 2,148
pituitary cancer 223 | 1,972
ulcerative colitis 221 | 2,087
group 3 medulloblastoma 212 | 2,254
Multiple myeloma 202 | 1,327
group 4 medulloblastoma 197 | 1,875
interstitial cystitis 197 | 2,299
medulloblastoma 196 | 1,524
astrocytoma 184 | 1,493
diabetes mellitus 179 | 1,663
ductal carcinoma in situ 171 | 1,745
posterior fossa group A ependymoma 162 | 1,511
cystic fibrosis 160 | 1,665
tuberculosis 153 | 1,557
sonic hedgehog group medulloblastoma 151 | 1,482
breast carcinoma 150 | 1,614
colon cancer 150 | 1,475
posterior fossa group B ependymoma 146 | 1,530
acute quadriplegic myopathy 142 | 1,157
Cancer 140 | 2,346
adrenocortical carcinoma 138 | 1,427
atypical teratoid/rhabdoid tumor 134 | 1,095
primary pancreatic ductal adenocarcinoma 126 | 1,271
Rheumatoid Arthritis 125 | 1,160
Epilepsy 121 | 346
active Crohn's disease 121 | 918
juvenile dermatomyositis 112 | 1,189
non primary Sjogren syndrome sicca 110 | 840
dermatomyositis 99 | 933
progressive supranuclear palsy 98 | 674
Obesity 95 | 616
Waldenstrons macroglobulinemia 95 | 765
cutaneous lupus erythematosus 95 | 1,056
spina bifida 95 | 1,064
Alzheimer's disease 93 | 644
Intellectual disability 86 | 573
Schizophrenia 86 | 501
gastric carcinoma 86 | 832
active ulcerative colitis 79 | 477
acute myeloid leukemia 78 | 780
nasopharyngeal carcinoma 77 | 1,056
tuberculosis and treatment for 6 months 77 | 686
Atopic dermatitis 76 | 944
aldosterone-producing adenoma 74 | 664
pancreatic carcinoma 74 | 567
Multiple Sclerosis 70 | 498
Neurodegenerative disease 70 | 383
Parkinson's disease 66 | 364
esophageal adenocarcinoma 64 | 737
Down syndrome 61 | 548
mucosa-associated lymphoid tissue lymphoma 59 | 480
primary Sjogren syndrome 59 | 789
Autistic Disorder 58 | 320
IGA Glomerulonephritis 57 | 454
Duchenne muscular dystrophy 55 | 602
hepatocellular carcinoma 54 | 532
Kidney disease 53 | 396
Diabetes mellitus type 2 52 | 69
Endometriosis 50 | 535
Amyotrophic Lateral Sclerosis 49 | 431
fibroadenoma 49 | 557
hereditary spastic paraplegia 49 | 313
Bipolar Disorder 48 | 266
Hypertension 47 | 287
Treatment Refractory Type 2 Diabetes Mellitus 47 | 53
chronic rhinosinusitis 44 | 512
nephrosclerosis 44 | 329
Colorectal Neoplasms 43 | 217
gastric cancer 43 | 430
Anemia 42 | 252
Heart disease 42 | 279
Eaton-Lambert syndrome 40 | 40
autosomal dominant Emery-Dreifuss muscular dystrophy 40 | 499

Tissue

Nervous System 1,933 | 18,561
Digestive Tract 1,931 | 18,473
Female tissues 1,930 | 18,647
Urinary Tract 1,930 | 18,444
Endocrine System 1,929 | 18,512
Liver and Pancreas 1,925 | 18,136
Blood and immune system 1,913 | 17,995
Cardiovascular System 1,913 | 17,958
Skin and soft tissues 1,910 | 18,115
Male tissues 1,907 | 17,969
Respiratory system 1,891 | 17,484

Target Family

Non-IDG 927 | 11,971
Transporter 422 | 473
Ion Channel 341 | 341
Enzyme 261 | 4,146
Kinase 7 | 634
Transcription Factor 4 | 1,400
Epigenetic 2 | 242

UniProt Keyword

Transport 1,964 | 1,964
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166