Development Level

Tbio 2,423 | 10,625
Tdark 1,821 | 7,003
Tchem 578 | 1,890
Tclin 372 | 602

Collection

Eligible non-olfactory GPCR Proteins 143 | 143
Eligible Ion Channel Proteins 108 | 117
Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, complete... 112 | 633
abnormal behavior 60 | 226
preweaning lethality, incomple... 59 | 260
decreased total body fat amoun... 50 | 186
decreased lean body mass 48 | 195
decreased bone mineral content 45 | 157
decreased body weight 38 | 174
embryonic lethality prior to t... 37 | 187
abnormal bone structure 34 | 131
decreased bone mineral density 33 | 126
enlarged heart 31 | 111
increased circulating alkaline... 31 | 119
hyperactivity 30 | 108
decreased grip strength 29 | 123
increased lean body mass 28 | 107
decreased circulating glucose ... 27 | 121
increased mean corpuscular vol... 26 | 91
increased or absent threshold ... 26 | 128
increased mean corpuscular hem... 24 | 93
increased bone mineral content 23 | 92
increased circulating sodium l... 23 | 71
abnormal retina morphology 22 | 100
decreased circulating triglyce... 21 | 83
embryonic lethality prior to o... 21 | 148
hypoactivity 21 | 89
decreased body length 20 | 108
decreased rib number 20 | 59
abnormal gait 19 | 51
abnormal sleep behavior 19 | 63
increased grip strength 19 | 83
decreased circulating choleste... 18 | 85
decreased circulating serum al... 18 | 79
improved glucose tolerance 18 | 56
abnormal embryo size 17 | 112
decreased fasted circulating g... 17 | 49
increased circulating calcium ... 17 | 32
abnormal seminal vesicle morph... 16 | 47
decreased circulating insulin ... 16 | 75
enlarged epididymis 16 | 27
increased fasted circulating g... 16 | 68
increased total body fat amoun... 16 | 57
short tibia 16 | 82
abnormal epididymis morphology 15 | 31
abnormal eye morphology 15 | 38
decreased circulating alanine ... 15 | 53
decreased prepulse inhibition 15 | 52
increased circulating potassiu... 15 | 31
increased exploration in new e... 15 | 56
abnormal retinal pigmentation 14 | 61
decreased circulating HDL chol... 14 | 77
decreased heart weight 14 | 44
impaired glucose tolerance 14 | 52
increased bone mineral density 14 | 52
tremors 14 | 34
abnormal bone mineralization 13 | 55
cardiovascular system phenotyp... 13 | 35
decreased leukocyte cell numbe... 13 | 54
decreased lumbar vertebrae num... 13 | 62
decreased startle reflex 13 | 48
increased blood urea nitrogen ... 13 | 44
increased sacral vertebrae num... 13 | 62
abnormal lens morphology 12 | 73
decreased eosinophil cell numb... 12 | 41
decreased hemoglobin content 12 | 53
increased rib number 12 | 41
limb grasping 12 | 35
abnormal heart morphology 11 | 51
decreased NK T cell number 11 | 28
increased circulating HDL chol... 11 | 63
increased circulating choleste... 11 | 53
straub tail 11 | 26
thrombocytopenia 11 | 46
decreased caudal vertebrae num... 10 | 49
decreased erythrocyte cell num... 10 | 43
decreased mean corpuscular vol... 10 | 50
increased heart weight 10 | 37
increased leukocyte cell numbe... 10 | 37
small testis 10 | 37
abnormal behavioral response t... 9 | 52
abnormal coat/hair pigmentatio... 9 | 54
abnormal neural tube closure 9 | 37
abnormal testis morphology 9 | 30
decreased T cell number 9 | 31
decreased circulating alkaline... 9 | 41
decreased circulating total pr... 9 | 41
decreased monocyte cell number 9 | 28
enlarged spleen 9 | 26
increased body weight 9 | 42
increased circulating chloride... 9 | 43
increased circulating serum al... 9 | 25
increased prepulse inhibition 9 | 21
prenatal lethality prior to he... 9 | 64
abnormal QRS complex 8 | 25
abnormal coat appearance 8 | 25
absent vibrissae 8 | 14
decreased circulating calcium ... 8 | 33
decreased circulating chloride... 8 | 32
decreased mean corpuscular hem... 8 | 34
increased hematocrit 8 | 36
increased hemoglobin content 8 | 45

Disease

ovarian cancer 1,954 | 8,484
osteosarcoma 1,946 | 7,933
psoriasis 1,783 | 6,685
medulloblastoma, large-cell 1,641 | 6,234
glioblastoma 1,488 | 5,572
atypical teratoid / rhabdoid tumor 1,168 | 4,369
lung cancer 1,039 | 4,466
pilocytic astrocytoma 997 | 3,086
lung carcinoma 979 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 850 | 3,289
invasive ductal carcinoma 832 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 817 | 2,956
interstitial cystitis 800 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 796 | 2,988
Breast cancer 776 | 3,094
lung adenocarcinoma 773 | 2,713
non-small cell lung cancer 773 | 2,798
pediatric high grade glioma 765 | 2,712
primitive neuroectodermal tumor 759 | 3,031
malignant mesothelioma 747 | 3,162
oligodendroglioma 738 | 2,849
Carcinoma 665 | 2,147
ependymoma 663 | 2,514
pancreatic cancer 657 | 2,300
ulcerative colitis 650 | 2,087
subependymal giant cell astrocytoma 634 | 2,287
pituitary cancer 586 | 1,972
adult high grade glioma 580 | 2,148
astrocytic glioma 569 | 2,241
Cancer 562 | 2,346
ductal carcinoma in situ 510 | 1,745
group 4 medulloblastoma 496 | 1,875
diabetes mellitus 489 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 485 | 1,795
cystic fibrosis 482 | 1,665
posterior fossa group A ependymoma 471 | 1,511
group 3 medulloblastoma 469 | 2,254
Pick disease 467 | 1,893
tuberculosis 453 | 1,557
breast carcinoma 431 | 1,614
medulloblastoma 384 | 1,524
astrocytoma 374 | 1,493
cutaneous lupus erythematosus 358 | 1,056
posterior fossa group B ependymoma 357 | 1,530
sonic hedgehog group medulloblastoma 357 | 1,482
adrenocortical carcinoma 355 | 1,427
primary pancreatic ductal adenocarcinoma 354 | 1,271
colon cancer 352 | 1,475
Rheumatoid Arthritis 336 | 1,160
active Crohn's disease 319 | 918
atypical teratoid/rhabdoid tumor 311 | 1,095
Multiple myeloma 260 | 1,327
juvenile dermatomyositis 254 | 1,189
primary Sjogren syndrome 244 | 789
gastric carcinoma 241 | 832
nasopharyngeal carcinoma 236 | 1,056
spina bifida 233 | 1,064
acute quadriplegic myopathy 231 | 1,157
Atopic dermatitis 229 | 944
Multiple Sclerosis 220 | 498
non primary Sjogren syndrome sicca 208 | 840
esophageal adenocarcinoma 205 | 737
Obesity 192 | 616
Alzheimer's disease 190 | 644
dermatomyositis 189 | 933
aldosterone-producing adenoma 188 | 664
Schizophrenia 181 | 501
mucosa-associated lymphoid tissue lymphoma 181 | 480
active ulcerative colitis 174 | 477
Down syndrome 172 | 548
Epilepsy 172 | 346
Duchenne muscular dystrophy 170 | 602
fibroadenoma 162 | 557
pancreatic carcinoma 158 | 567
acute myeloid leukemia 155 | 780
progressive supranuclear palsy 155 | 674
tuberculosis and treatment for 6 months 150 | 686
Hypersensitivity reaction type II disease 140 | 235
IGA Glomerulonephritis 140 | 454
Kidney disease 132 | 396
Asthma 131 | 349
Endometriosis 129 | 535
Intellectual disability 129 | 573
non-small cell lung carcinoma 129 | 413
Waldenstrons macroglobulinemia 121 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 119 | 499
Autistic Disorder 118 | 320
Neurodegenerative disease 117 | 383
Prostatic Neoplasms 117 | 471
nephrosclerosis 115 | 329
Parkinson's disease 108 | 364
hepatocellular carcinoma 107 | 532
sarcoidosis 106 | 358
Arthritis 102 | 248
Hypertension 102 | 287
Anemia 101 | 252
glioblastoma multiforme 101 | 347
chronic rhinosinusitis 100 | 512
urothelial carcinoma 99 | 318
Ankylosing spondylitis 97 | 138

Tissue

Female tissues 4,822 | 18,647
Urinary Tract 4,784 | 18,444
Nervous System 4,755 | 18,561
Endocrine System 4,741 | 18,512
Digestive Tract 4,716 | 18,473
Skin and soft tissues 4,612 | 18,115
Liver and Pancreas 4,574 | 18,136
Cardiovascular System 4,512 | 17,958
Blood and immune system 4,510 | 17,995
Male tissues 4,471 | 17,969
Respiratory system 4,386 | 17,484

Target Family

Non-IDG 2,582 | 11,971
Enzyme 884 | 4,146
Transporter 462 | 473
oGPCR 421 | 421
GPCR 406 | 406
Ion Channel 328 | 341
Kinase 88 | 634
Transcription Factor 21 | 1,400
Epigenetic 2 | 242

UniProt Keyword

Transmembrane helix 5,194 | 5,194
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3