Development Level

Tbio 2,547 | 11,178
Tdark 1,708 | 6,569
Tchem 574 | 1,885
Tclin 378 | 612

Collection

GPCR: IDG Consortium (Targets) 126 | 126
Ion Channel: IDG Consortium (T... 91 | 99
GPCR: IDG Consortium (Complete... 25 | 25
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 163 | 979
preweaning lethality, incomple... 120 | 499
abnormal behavior 82 | 298
decreased vertical activity 72 | 208
enlarged heart 61 | 210
embryonic lethality prior to t... 58 | 278
decreased total body fat amoun... 54 | 207
abnormal bone structure 49 | 187
increased lean body mass 49 | 172
hyperactivity 45 | 148
decreased bone mineral content 44 | 151
increased total body fat amoun... 43 | 134
embryonic lethality prior to o... 42 | 239
abnormal embryo size 41 | 220
abnormal heart morphology 40 | 162
decreased body weight 38 | 161
abnormal seminal vesicle morph... 36 | 114
decreased lean body mass 35 | 135
decreased bone mineral density 32 | 126
hypoactivity 30 | 132
decreased circulating glucose ... 29 | 126
increased bone mineral content 29 | 108
decreased grip strength 27 | 116
improved glucose tolerance 27 | 79
increased mean corpuscular vol... 27 | 92
increased circulating alkaline... 26 | 122
decreased body length 25 | 101
decreased lymphocyte cell numb... 25 | 83
increased or absent threshold ... 25 | 101
abnormal gait 24 | 69
increased startle reflex 24 | 112
abnormal eye morphology 23 | 68
abnormal sleep behavior 23 | 70
decreased startle reflex 23 | 75
decreased fasted circulating g... 22 | 65
decreased prepulse inhibition 22 | 82
increased circulating sodium l... 22 | 71
abnormal epididymis morphology 21 | 42
embryonic growth retardation 21 | 106
increased mean corpuscular hem... 21 | 96
small superior vagus ganglion 21 | 74
decreased circulating choleste... 20 | 93
decreased mean corpuscular vol... 20 | 79
abnormal kidney morphology 19 | 65
decreased hemoglobin content 19 | 68
impaired glucose tolerance 19 | 75
increased monocyte cell number 19 | 63
decreased circulating serum al... 18 | 82
decreased leukocyte cell numbe... 18 | 73
enlarged epididymis 18 | 31
increased circulating HDL chol... 18 | 80
increased fasted circulating g... 18 | 76
limb grasping 18 | 41
short tibia 18 | 97
decreased erythrocyte cell num... 17 | 62
male infertility 17 | 123
cataract 16 | 92
decreased circulating HDL chol... 16 | 68
decreased circulating insulin ... 16 | 76
decreased circulating triglyce... 16 | 79
increased circulating calcium ... 16 | 34
abnormal behavioral response t... 15 | 66
decreased heart weight 15 | 27
enlarged spleen 15 | 41
increased circulating triglyce... 15 | 42
increased heart weight 15 | 62
abnormal lens morphology 14 | 81
abnormal retina morphology 14 | 71
abnormal skin morphology 14 | 50
abnormal spleen morphology 14 | 55
decreased circulating alkaline... 14 | 46
increased leukocyte cell numbe... 14 | 47
prenatal lethality prior to he... 14 | 87
tremors 14 | 39
abnormal coat-hair pigmentatio... 13 | 64
decreased circulating total pr... 13 | 49
increased bone mineral density 13 | 72
increased circulating choleste... 13 | 66
small testis 13 | 58
thrombocytopenia 13 | 56
abnormal testis morphology 12 | 43
cardiovascular system phenotyp... 12 | 36
decreased red blood cell distr... 12 | 41
edema 12 | 59
hydrometra 12 | 53
increased neutrophil cell numb... 12 | 46
prolonged QT interval 12 | 38
abnormal neural tube closure 11 | 46
abnormal vibrissa morphology 11 | 25
decreased hematocrit 11 | 46
decreased mean corpuscular hem... 11 | 50
increased circulating amylase ... 11 | 25
increased circulating creatini... 11 | 38
increased red blood cell distr... 11 | 34
abnormal locomotor behavior 10 | 24
decreased circulating creatini... 10 | 39
increased circulating chloride... 10 | 41
increased circulating potassiu... 10 | 29
increased mean platelet volume 10 | 45
prolonged ST segment 10 | 36

Disease

Carcinoma 3,122 | 11,192
ovarian cancer 1,909 | 8,297
osteosarcoma 1,880 | 7,766
psoriasis 1,738 | 6,514
medulloblastoma, large-cell 1,591 | 6,086
glioblastoma 1,498 | 5,635
atypical teratoid / rhabdoid tumor 1,337 | 4,971
ependymoma 1,218 | 4,559
lung cancer 1,101 | 4,607
adult high grade glioma 1,027 | 3,701
Astrocytoma, Pilocytic 960 | 3,006
lung carcinoma 944 | 2,755
group 3 medulloblastoma 909 | 4,002
Breast cancer 874 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 819 | 3,204
invasive ductal carcinoma 801 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 789 | 2,872
non-small cell lung cancer 780 | 2,799
interstitial cystitis 775 | 2,237
intraductal papillary-mucinous carcinoma (IPMC) 767 | 2,902
lung adenocarcinoma 748 | 2,627
malignant mesothelioma 736 | 3,135
primitive neuroectodermal tumor 736 | 2,957
oligodendroglioma 713 | 2,768
Kidney cancer 708 | 2,548
pancreatic cancer 670 | 2,322
astrocytic glioma 639 | 2,530
subependymal giant cell astrocytoma 617 | 2,230
tuberculosis 597 | 1,963
Cancer 577 | 2,388
pituitary cancer 563 | 1,915
ulcerative colitis 539 | 1,765
pancreatic ductal adenocarcinoma liver metastasis 508 | 1,911
diabetes mellitus 496 | 1,683
ductal carcinoma in situ 486 | 1,686
cystic fibrosis 471 | 1,629
group 4 medulloblastoma 463 | 1,806
Pick disease 454 | 1,856
breast carcinoma 421 | 1,589
Autosomal recessive predisposition 398 | 1,407
Schizophrenia 386 | 1,136
adrenocortical carcinoma 345 | 1,385
cutaneous lupus erythematosus 345 | 1,016
Rheumatoid arthritis 340 | 1,156
colon cancer 334 | 1,428
active Crohn's disease 302 | 882
primary pancreatic ductal adenocarcinoma 301 | 1,071
astrocytoma 279 | 1,113
pediatric high grade glioma 275 | 1,035
Epilepsy 273 | 775
active ulcerative colitis 258 | 736
Multiple myeloma 252 | 1,296
juvenile dermatomyositis 241 | 1,147
Melanoma 236 | 689
spina bifida 229 | 1,053
Multiple Sclerosis 227 | 527
acute quadriplegic myopathy 225 | 1,133
Intellectual disability 224 | 998
Bipolar Disorder 223 | 646
gastric carcinoma 223 | 781
nasopharyngeal carcinoma 223 | 1,024
non primary Sjogren syndrome sicca 222 | 861
Atopic dermatitis 219 | 915
primary Sjogren syndrome 215 | 710
dermatomyositis 214 | 941
Liver Cirrhosis, Experimental 205 | 733
Liver cancer 192 | 589
Obesity 191 | 655
esophageal adenocarcinoma 191 | 696
Skin cancer 189 | 451
Alzheimer's disease 186 | 640
aldosterone-producing adenoma 183 | 646
mucosa-associated lymphoid tissue lymphoma 178 | 473
medulloblastoma 175 | 702
Seizures 172 | 584
Duchenne muscular dystrophy 166 | 587
fibroadenoma 158 | 538
pancreatic carcinoma 156 | 555
progressive supranuclear palsy 150 | 656
Muscle hypotonia 149 | 562
acute myeloid leukemia 149 | 760
Dull intelligence 147 | 634
Low intelligence 147 | 634
Mental Retardation 147 | 634
Mental deficiency 147 | 634
Poor school performance 147 | 634
Down syndrome 146 | 480
Hypersensitivity reaction type II disease 140 | 245
Depressive disorder 138 | 401
posterior fossa group A ependymoma 138 | 456
Cognitive delay 134 | 596
Global developmental delay 134 | 596
Mental and motor retardation 134 | 596
Kidney disease 133 | 411
Asthma 131 | 370
Hypertension 131 | 372
Endometriosis 126 | 521
Autistic Disorder 125 | 358
Alcoholic Intoxication, Chronic 123 | 283
Mental Depression 119 | 325

Tissue

Endocrine System 4,546 | 18,159
Female tissues 4,305 | 17,400
Digestive Tract 4,302 | 17,369
Male tissues 4,218 | 17,142
Skin and soft tissues 4,215 | 17,230
Nervous System 4,147 | 16,725
Blood and immune system 4,136 | 16,909
Urinary Tract 4,116 | 16,678
Liver and Pancreas 4,114 | 16,750
Respiratory system 3,974 | 16,393
Cardiovascular System 3,601 | 15,192

Target Family

Non-IDG 2,589 | 12,091
Enzyme 885 | 4,145
Transporter 462 | 473
oGPCR 421 | 421
GPCR 408 | 408
Ion Channel 331 | 344
Kinase 88 | 634
Transcription Factor 21 | 1,400
Epigenetic 2 | 242

UniProt Keyword

Transmembrane helix 5,207 | 5,207
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
Taste receptor type 1 member 2 TAS1R2 Tchem GPCR -2.03403 100.4 150
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121