Development Level

Tbio 2,611 | 11,445
Tdark 1,716 | 6,588
Tchem 522 | 1,598
Tclin 379 | 613

Collection

RFA-RM-18-021 204 | 328
GPCR: IDG Consortium (Targets) 126 | 126
Ion Channel: IDG Consortium (T... 91 | 99
GPCR: IDG Consortium (Complete... 25 | 25
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 164 | 979
preweaning lethality, incomple... 121 | 499
abnormal behavior 83 | 298
decreased vertical activity 72 | 208
enlarged heart 61 | 210
embryonic lethality prior to t... 58 | 278
decreased total body fat amoun... 54 | 207
abnormal bone structure 49 | 187
increased lean body mass 49 | 172
hyperactivity 46 | 148
decreased bone mineral content 44 | 151
increased total body fat amoun... 43 | 134
abnormal embryo size 42 | 220
embryonic lethality prior to o... 42 | 239
abnormal heart morphology 40 | 162
decreased body weight 38 | 161
abnormal seminal vesicle morph... 36 | 114
decreased lean body mass 35 | 135
decreased bone mineral density 32 | 126
hypoactivity 30 | 132
decreased circulating glucose ... 29 | 126
increased bone mineral content 29 | 108
decreased grip strength 27 | 116
improved glucose tolerance 27 | 79
increased mean corpuscular vol... 27 | 92
increased circulating alkaline... 26 | 122
decreased body length 25 | 101
decreased lymphocyte cell numb... 25 | 83
increased or absent threshold ... 25 | 101
abnormal gait 24 | 69
increased startle reflex 24 | 112
abnormal eye morphology 23 | 68
abnormal sleep behavior 23 | 70
decreased prepulse inhibition 23 | 82
decreased startle reflex 23 | 75
increased circulating sodium l... 23 | 71
decreased fasted circulating g... 22 | 65
abnormal epididymis morphology 21 | 42
embryonic growth retardation 21 | 106
increased mean corpuscular hem... 21 | 96
small superior vagus ganglion 21 | 74
decreased circulating choleste... 20 | 93
decreased mean corpuscular vol... 20 | 79
abnormal kidney morphology 19 | 65
decreased hemoglobin content 19 | 68
impaired glucose tolerance 19 | 75
increased monocyte cell number 19 | 63
decreased circulating serum al... 18 | 82
decreased leukocyte cell numbe... 18 | 73
enlarged epididymis 18 | 31
increased circulating HDL chol... 18 | 80
increased fasted circulating g... 18 | 76
limb grasping 18 | 41
short tibia 18 | 97
cataract 17 | 92
decreased erythrocyte cell num... 17 | 62
male infertility 17 | 123
decreased circulating HDL chol... 16 | 68
decreased circulating insulin ... 16 | 76
decreased circulating triglyce... 16 | 79
decreased heart weight 16 | 27
increased circulating calcium ... 16 | 34
abnormal behavioral response t... 15 | 66
enlarged spleen 15 | 41
increased circulating triglyce... 15 | 42
increased heart weight 15 | 62
abnormal lens morphology 14 | 81
abnormal retina morphology 14 | 71
abnormal skin morphology 14 | 50
abnormal spleen morphology 14 | 55
decreased circulating alkaline... 14 | 46
increased leukocyte cell numbe... 14 | 47
prenatal lethality prior to he... 14 | 87
tremors 14 | 39
abnormal coat-hair pigmentatio... 13 | 64
cardiovascular system phenotyp... 13 | 36
decreased circulating total pr... 13 | 49
increased bone mineral density 13 | 72
increased circulating choleste... 13 | 66
small testis 13 | 58
thrombocytopenia 13 | 56
abnormal testis morphology 12 | 43
decreased red blood cell distr... 12 | 41
edema 12 | 59
hydrometra 12 | 53
increased neutrophil cell numb... 12 | 46
prolonged QT interval 12 | 38
abnormal neural tube closure 11 | 46
abnormal vibrissa morphology 11 | 25
decreased hematocrit 11 | 46
decreased mean corpuscular hem... 11 | 50
increased circulating amylase ... 11 | 25
increased circulating creatini... 11 | 38
increased red blood cell distr... 11 | 34
abnormal locomotor behavior 10 | 24
decreased circulating creatini... 10 | 39
increased circulating chloride... 10 | 41
increased circulating potassiu... 10 | 29
increased mean platelet volume 10 | 45
prolonged ST segment 10 | 36

Disease

Carcinoma 3,242 | 11,493
ovarian cancer 1,972 | 8,520
osteosarcoma 1,959 | 7,950
psoriasis 1,801 | 6,694
medulloblastoma, large-cell 1,640 | 6,241
glioblastoma 1,544 | 5,792
atypical teratoid / rhabdoid tumor 1,382 | 5,112
ependymoma 1,259 | 4,679
lung cancer 1,152 | 4,740
adult high grade glioma 1,061 | 3,801
Astrocytoma, Pilocytic 989 | 3,081
lung carcinoma 984 | 2,843
group 3 medulloblastoma 935 | 4,104
Breast cancer 917 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 854 | 3,291
invasive ductal carcinoma 834 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 822 | 2,955
non-small cell lung cancer 815 | 2,890
interstitial cystitis 808 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 799 | 2,989
lung adenocarcinoma 783 | 2,716
malignant mesothelioma 765 | 3,232
primitive neuroectodermal tumor 754 | 3,035
Kidney cancer 740 | 2,613
oligodendroglioma 739 | 2,850
pancreatic cancer 698 | 2,398
astrocytic glioma 658 | 2,597
subependymal giant cell astrocytoma 632 | 2,287
tuberculosis 608 | 2,010
Cancer 603 | 2,499
pituitary cancer 589 | 1,972
ulcerative colitis 562 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 530 | 1,962
ductal carcinoma in situ 512 | 1,745
diabetes mellitus 504 | 1,728
cystic fibrosis 498 | 1,696
group 4 medulloblastoma 480 | 1,855
Pick disease 468 | 1,894
breast carcinoma 439 | 1,638
Autosomal recessive predisposition 414 | 1,442
Schizophrenia 394 | 1,160
cutaneous lupus erythematosus 363 | 1,057
adrenocortical carcinoma 358 | 1,428
Rheumatoid arthritis 357 | 1,191
colon cancer 354 | 1,478
active Crohn's disease 321 | 922
primary pancreatic ductal adenocarcinoma 315 | 1,109
astrocytoma 291 | 1,146
Epilepsy 282 | 792
pediatric high grade glioma 282 | 1,064
active ulcerative colitis 272 | 764
Multiple myeloma 261 | 1,332
juvenile dermatomyositis 252 | 1,187
Melanoma 247 | 711
nasopharyngeal carcinoma 240 | 1,058
spina bifida 235 | 1,074
Atopic dermatitis 232 | 952
acute quadriplegic myopathy 232 | 1,158
gastric carcinoma 232 | 807
Multiple Sclerosis 230 | 540
non primary Sjogren syndrome sicca 229 | 891
Bipolar Disorder 228 | 666
Intellectual disability 227 | 1,016
primary Sjogren syndrome 225 | 735
dermatomyositis 222 | 966
Liver Cirrhosis, Experimental 216 | 769
esophageal adenocarcinoma 211 | 737
Alzheimer's disease 202 | 658
Obesity 200 | 678
Skin cancer 200 | 469
Liver cancer 199 | 604
aldosterone-producing adenoma 189 | 665
mucosa-associated lymphoid tissue lymphoma 182 | 484
medulloblastoma 181 | 720
Seizures 176 | 596
Duchenne muscular dystrophy 170 | 601
fibroadenoma 163 | 559
acute myeloid leukemia 158 | 783
pancreatic carcinoma 158 | 562
progressive supranuclear palsy 155 | 676
Down syndrome 152 | 499
Muscle hypotonia 151 | 571
Dull intelligence 149 | 645
Low intelligence 149 | 645
Mental Retardation 149 | 645
Mental deficiency 149 | 645
Poor school performance 149 | 645
Hypersensitivity reaction type II disease 145 | 253
Depressive disorder 143 | 409
posterior fossa group A ependymoma 141 | 468
Hypertension 139 | 396
Kidney disease 138 | 430
Cognitive delay 137 | 608
Global developmental delay 137 | 608
Mental and motor retardation 137 | 608
Asthma 136 | 385
Endometriosis 132 | 540
Anemia 127 | 365
Autistic Disorder 127 | 364
Alcoholic Intoxication, Chronic 126 | 289

Tissue

Endocrine System 4,564 | 18,159
Female tissues 4,322 | 17,400
Digestive Tract 4,320 | 17,369
Male tissues 4,235 | 17,142
Skin and soft tissues 4,233 | 17,230
Nervous System 4,163 | 16,725
Blood and immune system 4,153 | 16,909
Urinary Tract 4,135 | 16,678
Liver and Pancreas 4,133 | 16,750
Respiratory system 3,990 | 16,393
Cardiovascular System 3,617 | 15,192

Target Family

Non-IDG 2,602 | 12,091
Enzyme 891 | 4,145
Transporter 462 | 473
oGPCR 421 | 421
GPCR 408 | 408
Ion Channel 331 | 344
Kinase 88 | 634
Transcription Factor 21 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Transmembrane 5,228 | 5,228
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Transmembrane protein 184C TMEM184C Tbio Non-IDG -0.23045 1.81 39